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Akademický článek

Long-term mood/antidepressant effects of quetiapine extended-release formulation: an open-label, non-controlled extension study in Japanese patients with bipolar depression

Autor: Shigenobu Kanba, Mitsukuni Murasaki, Tsukasa Koyama, Masahiro Takeuchi, Yuriko Shimizu, Eri Arita, Kentaro Kuroishi, Shinya Kamei

Publikováno v: BMC Psychiatry, Vol 19, Iss 1, Pp 1-10 (2019)

Abstract Background In an 8-week, randomized, placebo-controlled, double-blind study, an extended-release formulation of quetiapine, quetiapine XR, demonstrated efficacy and safety in Japanese patients with bipolar depression. Bipolar disorder is a c

Externí odkaz: https://doaj.org/article/2572161ce5ee46518df94a47506796f6

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Akademický článek

Bile acid binding resin improves metabolic control through the induction of energy expenditure.

Autor: Mitsuhiro Watanabe, Kohkichi Morimoto, Sander M Houten, Nao Kaneko-Iwasaki, Taichi Sugizaki, Yasushi Horai, Chikage Mataki, Hiroyuki Sato, Karin Murahashi, Eri Arita, Kristina Schoonjans, Tatsuya Suzuki, Hiroshi Itoh, Johan Auwerx

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e38286 (2012)

BACKGROUND: Besides well-established roles of bile acids (BA) in dietary lipid absorption and cholesterol homeostasis, it has recently become clear that BA is also a biological signaling molecule. We have shown that strategies aimed at activating TGR

Externí odkaz: https://doaj.org/article/b98388e7c89a4f5a94e80c6a0e46920d

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Muscarinic‐3‐receptor positive allosteric modulator ASP8302 in patients with underactive bladder. A randomized controlled trial

Autor: Jan Willem Olivier van Till, Eri Arita, Kentaro Kuroishi, Richard Croy, Matthias Oelke, Gommert A. van Koeveringe, Christopher R. Chapple, Osamu Yamaguchi, Paul Abrams

Publikováno v: Neurourology and Urodynamics, 41(5), 1139-1148. Wiley

AIM: The aim of this study is to evaluate safety and efficacy of ASP8302, a novel positive allosteric modulator for the muscarinic M3 receptor (M3-PAM), in patients with underactive bladder (UAB).METHODS: A randomized, double-blind, placebo-controlle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d51406ce701049724f93914fe7de0fe
https://doi.org/10.1002/nau.24931

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The Niemann-Pick C1 Like 1 (NPC1L1) Inhibitor Ezetimibe Improves Metabolic Disease Via Decreased Liver X Receptor (LXR) Activity in Liver of Obese Male Mice

Autor: Yasushi Horai, Teruo Miyazaki, Nao Kaneko-Iwasaki, Junichiro Irie, Mitsuhiro Watanabe, Eri Arita, Akira Honda, Kohkichi Morimoto, Hiroshi Itoh, Taichi Sugizaki

Publikováno v: Endocrinology. 155:2810-2819

Dyslipidemic patients with diabetes mellitus, including metabolic syndrome, are at increased risk of coronary heart disease. It has been reported that ezetimibe, a cholesterol absorption inhibitor, improves metabolic diseases in mice and humans. Howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a62193e842ec1f20133d51378ad2c61
https://doi.org/10.1210/en.2013-2143

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Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure

Autor: Yusuke Tanigawara, Taichi Sugizaki, Hiroshi Itoh, Johan Auwerx, Sander M. Houten, Chikage Mataki, Eri Arita, Kohkichi Morimoto, Yasushi Horai, Hiroyuki Sato, Kristina Schoonjans, Mitsuhiro Watanabe

Publikováno v: Journal of biological chemistry, 286(30), 26913-26920. American Society for Biochemistry and Molecular Biology Inc.
The Journal of biological chemistry

We evaluated the metabolic impact of farnesoid X receptor (FXR) activation by administering a synthetic FXR agonist (GW4064) to mice in which obesity was induced by a high fat diet. Administration of GW4064 accentuated body weight gain and glucose in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af22770dfc41ca5bec2e978b2f61e87
https://doi.org/10.1074/jbc.m111.248203

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Evaluation of promoter strength in mouse and rat primary hepatocytes using adenovirus vectors

Autor: Kiyohito Yagi, Takeshi Yoshida, Katsuhiro Isoda, Masuo Kondoh, Eri Arita, Hikaru Nishimori, Hiroyuki Mizuguchi

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics. 70:1-6

Primary cultured hepatocytes are widely used in the studies of basic and clinical hepatology. Finding an efficient method for gene transfer into primary hepatocytes will be an important advance for these studies. In the present study, we evaluated th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee1377a7a5b899918b57221247fffa2
https://doi.org/10.1016/j.ejpb.2008.03.013

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Stimulation of hepatocyte survival and suppression of CCl4-induced liver injury by the adenovirally introduced C/EBPβ gene

Autor: Hiroko Koide, Masahiro Ikkaku, Jun-ichi Miyazaki, Fumi Tashiro, Eri Arita, Eiji Yamato, Kiyohito Yagi, Midori Kojima, Katsuhiro Isoda, Shinji Higashiyama, Masaya Kawase

Publikováno v: Biochemical and Biophysical Research Communications. 329:182-187

Gene therapy has attracted attention as a potentially effective alternative to liver transplantation for the treatment of hepatic failure. We chose the C/EBPbeta gene, which plays vital roles in liver regeneration, as a candidate for gene therapy, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9cc308ddfc2517e576841b0ecceb23
https://doi.org/10.1016/j.bbrc.2005.01.113

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Novel Linkage Disequilibrium of Single Nucleotide Polymorphisms in the Transcriptional Regulatory Region of .MU.-Opioid Receptor Gene in Japanese Population

Autor: Eri Arita, Takeshi Ono, Akihiro Muto, Toshio Kaneda, Tadashi Yoshida

Publikováno v: Biological and Pharmaceutical Bulletin. 32:721-723

micro-Opioid receptor agonists, such as morphine, are widely applied in pain therapy clinical practice. However, the effects exerted by morphine via receptor are influenced by individual specificity. Single nucleotide polymorphisms (SNPs) in micro-op

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b233558f2427dd2858fe532c392e35
https://doi.org/10.1248/bpb.32.721

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