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Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia

Autor: Elim Na, Eri Allen, Lillia A. Baird, Christine V. Odom, Filiz T. Korkmaz, Anukul T. Shenoy, Adeline M. Matschulat, Matthew R. Jones, Darrell N. Kotton, Joseph P. Mizgerd, Xaralabos Varelas, Katrina E. Traber, Lee J. Quinton

Publikováno v: Am J Physiol Lung Cell Mol Physiol

During bacterial pneumonia, alveolar epithelial cells are critical for maintaining gas exchange and providing antimicrobial as well as pro-immune properties. We previously demonstrated that leukemia inhibitory factor (LIF), an IL-6 family cytokine, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab26ae13707e14d98d108963b965e65
https://doi.org/10.1152/ajplung.00325.2021

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Neutrophil-Derived Oncostatin M Triggers Diverse Signaling Pathways during Pneumonia

Autor: Ernest L. Dimbo, Elise M. Symer, Anukul T. Shenoy, Katrina E. Traber, Eri Allen, Lee J. Quinton, Joseph P. Mizgerd

Publikováno v: Infect Immun

Pneumonia is a major public health concern, causing significant morbidity and mortality annually despite the broad use of antimicrobial agents. Underlying many of the severe sequelae of acute lung infections is dysfunction of the immune response, whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ffb51e54820658103686b3a1e828a0
https://europepmc.org/articles/PMC8090961/

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NF-κB RelA Is Required for Hepatoprotection during Pneumonia and Sepsis

Autor: Matthew R. Jones, Y. Kim, Lee J. Quinton, Elise M. Symer, Eri Allen, Joseph P. Mizgerd, Katrina E. Traber, L. Baird, C. Odom, Filiz T. Korkmaz, E. Na

Publikováno v: Infection and immunity. 87(8)

Pneumonia and sepsis are distinct but integrally linked public health concerns. The hepatic acute-phase response (APR), which is largely dependent on transcription factors NF-κB RelA and STAT3, is a hallmark of these pathologies and other injurious

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e8427d3c19ff3f4f8d547cf83b8e64
https://pubmed.ncbi.nlm.nih.gov/31160364

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Induction of STAT3-Dependent CXCL5 Expression and Neutrophil Recruitment by Oncostatin-M during Pneumonia

Autor: Joseph P. Mizgerd, Eri Allen, Katrina E. Traber, Kazuko Yamamoto, Lee J. Quinton, Kristie L. Hilliard, Gregory A. Wasserman, Matthew R. Jones

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 53:479-488

Acute bacterial pneumonia is a significant public health concern worldwide. Understanding the signals coordinating lung innate immunity may foster the development of therapeutics that limit tissue damage and promote host defense. We have previously s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99ee341b15be7d049bb29f7ed3b13dc
https://doi.org/10.1165/rcmb.2014-0342oc

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Leukemia Inhibitory Factor Signaling Is Required for Lung Protection during Pneumonia

Autor: Matthew R. Jones, Candice Y. Kwon, Lee J. Quinton, Joseph P. Mizgerd, Eri Allen, Kristie L. Hilliard

Publikováno v: The Journal of Immunology. 188:6300-6308

Lung infections represent a tremendous disease burden and a leading cause of acute lung injury. STAT3 signaling is essential for controlling lung injury during pneumonia. We previously identified LIF as a prominent STAT3-activating cytokine expressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a4fbcf72d6b90c22a0d54e9be4e5a9c
https://doi.org/10.4049/jimmunol.1200256

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Activation of Hepatic STAT3 Maintains Pulmonary Defense during Endotoxemia

Autor: Katrina E. Traber, Gregory A. Wasserman, Matthew R. Jones, Joseph P. Mizgerd, Kristie L. Hilliard, Eri Allen, Y. Kim, Lee J. Quinton

Publikováno v: Infection and immunity. 83(10)

Pneumonia and infection-induced sepsis are worldwide public health concerns. Both pathologies elicit systemic inflammation and induce a robust acute-phase response (APR). Although APR activation is well regarded as a hallmark of infection, the direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e61e3e7c7b5cb0792a1a553280ce88
https://pubmed.ncbi.nlm.nih.gov/26216424

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The Lung-Liver Axis: A Requirement for Maximal Innate Immunity and Hepatoprotection during Pneumonia

Autor: Joseph P. Mizgerd, Kazuko Yamamoto, Nicole M. Stauffer, Eri Allen, Gregory A. Wasserman, Matthew R. Jones, Lee J. Quinton, Katrina E. Traber, Kristie L. Hilliard

Publikováno v: American journal of respiratory cell and molecular biology. 53(3)

The hepatic acute-phase response (APR), stimulated by injury or inflammation, is characterized by significant changes in circulating acute-phase protein (APP) concentrations. Although individual functions of liver-derived APPs are known, the net cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e00b1ed0116562489e89bfa1dfaaa5c
https://pubmed.ncbi.nlm.nih.gov/25607543

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Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice

Autor: Xiaoling Zhang, Joseph P. Mizgerd, Vishakha Sabharwal, Shizuo Akira, Matthew T. Blahna, Lee J. Quinton, Stephen I. Pelton, Eri Allen, Roland M. Schmid, Joseph D. Ferrari, Avrum Spira, Hana Algül, Matthew R. Jones, Kristie L. Hilliard

The acute phase response is an evolutionarily conserved reaction in which physiological stress triggers the liver to remodel the blood proteome. Although thought to be involved in immune defense, the net biological effect of the acute phase response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213b32dde02e9900299d01f99109c9d7
https://europepmc.org/articles/PMC3336975/

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