Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Eri, Tokumaru"'
Autor:
Masashi Numata, Noriyasu Haginoya, Machiko Shiroishi, Tsuyoshi Hirata, Aiko Sato-Otsubo, Kenji Yoshikawa, Yoshimi Takata, Reina Nagase, Yoshinori Kashimoto, Makoto Suzuki, Nina Schulte, Gernot Polier, Akiko Kurimoto, Yumiko Tomoe, Akiko Toyota, Tomoko Yoneyama, Emi Imai, Kenji Watanabe, Tomoaki Hamada, Ryutaro Kanada, Jun Watanabe, Yoshiko Kagoshima, Eri Tokumaru, Kenji Murata, Takayuki Baba, Taeko Shinozaki, Masami Ohtsuka, Koichi Goto, Tsuyoshi Karibe, Takao Deguchi, Yoshihiro Gocho, Masanori Yoshida, Daisuke Tomizawa, Motohiro Kato, Shinji Tsutsumi, Mayumi Kitagawa, Yuki Abe
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-16 (2023)
Abstract Background Mixed lineage leukemia 1-rearranged (MLL1-r) acute leukemia patients respond poorly to currently available treatments and there is a need to develop more effective therapies directly disrupting the Menin‒MLL1 complex. Small-mole
Externí odkaz:
https://doaj.org/article/f86d0f97c6f6435c8a15c5b3055bcdf2
Autor:
Narayan Karanjule, Noriyuki Hayashi, Sayaka Suzuki, Toshifumi Tsuda, Eri Tokumaru, Kyosuke Tanaka, Hiroko Kimoto, Yuki Domon, Sakiko Takahashi, Kazufumi Kubota, Yutaka Kitano, Tomihisa Yokoyama, Ryuta Koishi, Chie Fujiwara, Shinichi Inaba, Daigo Asano, Tomoko Sakakura, Kiyoshi Takasuna, Tsuyoshi Shinozuka
Publikováno v:
ACS Medicinal Chemistry Letters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dd20a57b9a34b89d6090c1968a55466
https://doi.org/10.1021/acsmedchemlett.3c00079
https://doi.org/10.1021/acsmedchemlett.3c00079
Autor:
Tomihisa Yokoyama, Sakiko Takahashi, Kiyoshi Takasuna, Noriyuki Hayashi, Hiroyuki Kobayashi, Ryuta Koishi, Chie Fujiwara, Eri Tokumaru, Yasuyuki Abe, Kyosuke Tanaka, Sayaka Suzuki, Kazufumi Kubota, Daigo Asano, Narayan Karanjule, Tsuyoshi Shinozuka, Masahiro Inoue, Hiroko Kimoto, Tsuda Toshifumi, Yutaka Kitano, Kiyono Ueda, Toshiyuki Watanabe, Yuki Domon, Tomoko Sakakura, Akiko Shimizugawa
Publikováno v:
Journal of Medicinal Chemistry. 63:10204-10220
A highly potent, selective NaV1.7 inhibitor, DS-1971a, has been discovered. Exploration of the left-hand phenyl ring of sulfonamide derivatives (I and II) led to the discovery of novel series of cycloalkane derivatives with high NaV1.7 inhibitory pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dfbfcf9264e87757e4b9e81ee00d139
https://doi.org/10.1021/acs.jmedchem.0c00259
https://doi.org/10.1021/acs.jmedchem.0c00259
Autor:
Tsuyoshi, Shinozuka, Hiroyuki, Kobayashi, Sayaka, Suzuki, Kyosuke, Tanaka, Narayan, Karanjule, Noriyuki, Hayashi, Toshifumi, Tsuda, Eri, Tokumaru, Masahiro, Inoue, Kiyono, Ueda, Hiroko, Kimoto, Yuki, Domon, Sakiko, Takahashi, Kazufumi, Kubota, Tomihisa, Yokoyama, Akiko, Shimizugawa, Ryuta, Koishi, Chie, Fujiwara, Daigo, Asano, Tomoko, Sakakura, Kiyoshi, Takasuna, Yasuyuki, Abe, Toshiyuki, Watanabe, Yutaka, Kitano
Publikováno v:
Journal of medicinal chemistry. 63(18)
A highly potent, selective Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79add99460610a6681f6e61187542eaa
https://pubmed.ncbi.nlm.nih.gov/32392056
https://pubmed.ncbi.nlm.nih.gov/32392056
Autor:
Jun Tanaka, Tsuneaki Ogata, Tsuyoshi Shinozuka, Eri Tokumaru, Nobuaki Watanabe, Satoko Wakimoto, Hideki Yamamoto, Kazushi Araki, Ryoko Sawamura, Makoto Mori, Yoshiyuki Onishi, Kunihiko Fujii, Masanori Kuroha, Yoshiro Tani, Tomoharu Tsukada, Jun Ohsumi, Kazunori Fujimoto, Kousei Shimada, Yumi Matsui
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:5079-5098
The lead identification of a novel potent selective PPARγ agonist, DS-6930 is reported. To avoid PPARγ-related adverse effects, a partial agonist was designed to prevent the direct interaction with helix 12 of PPARγ-LBD. Because the TZD group is k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed27157e1f634c62e341dd0f47d4f23c
https://doi.org/10.1016/j.bmc.2018.09.006
https://doi.org/10.1016/j.bmc.2018.09.006
Autor:
Tsuyoshi Shinozuka, Tomoharu Tsukada, Kunihiko Fujii, Eri Tokumaru, Kousei Shimada, Yoshiyuki Onishi, Yumi Matsui, Satoko Wakimoto, Masanori Kuroha, Tsuneaki Ogata, Kazushi Araki, Jun Ohsumi, Ryoko Sawamura, Nobuaki Watanabe, Hideki Yamamoto, Kazunori Fujimoto, Yoshiro Tani, Makoto Mori, Jun Tanaka
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:5099-5117
Attempts were made to reduce the lipophilicity of previously synthesized compound (II) for the avoidance of hepatotoxicity. The replacement of the left-hand side benzene with 2-pyridine resulted in the substantial loss of potency. Because poor membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a3af37a3214314dfb51a808cd5b731
https://doi.org/10.1016/j.bmc.2018.09.005
https://doi.org/10.1016/j.bmc.2018.09.005
Autor:
Tsuyoshi Shinozuka, Tomoharu Tsukada, Kunihiko Fujii, Eri Tokumaru, Yumi Matsui, Satoko Wakimoto, Tsuneaki Ogata, Kazushi Araki, Ryoko Sawamura, Nobuaki Watanabe, Makoto Mori, Jun Tanaka
Publikováno v:
ACS medicinal chemistry letters. 10(3)
[Image: see text] Derivatization efforts were continued to discover backups for a potent selective PPARγ modulator, DS-6930. In this Letter, the replacement of 2-pyridine ring in DS-6930 with 3- or 4-pyridyl group is reported. As the introduction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a900c46fe1fc0629ddfc9e3acb12770f
https://pubmed.ncbi.nlm.nih.gov/30891140
https://pubmed.ncbi.nlm.nih.gov/30891140
Publikováno v:
Chemistry Letters. 44:1768-1770
We report an effective dynamic kinetic resolution (DKR) system of racemic 2-(1H-pyrrol-1-yl)alkanoic acids, which consists of a rapid racemization step via an activating substrate and an enantio-di...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8f4935d050818611cb5f59062f2d703
https://doi.org/10.1246/cl.150826
https://doi.org/10.1246/cl.150826
Publikováno v:
Chemistry Letters; 12/5/2015, Vol. 44 Issue 12, p1768-1770, 3p
