Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Erhard Wintersberger"'
Publikováno v:
Molecular and Cellular Biology. 24:10986-10994
Polyomavirus large T antigen transactivates a variety of genes whose products are involved in S phase induction. These genes are regulated by the E2F family of transcription factors, which are under the control of the pocket protein retinoblastoma pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6b2a11cf143711ffb1a30855a92534
https://doi.org/10.1128/mcb.24.24.10986-10994.2004
https://doi.org/10.1128/mcb.24.24.10986-10994.2004
Autor:
Erhard Wintersberger
Publikováno v:
Chromosoma. 109:300-307
It has been known for about 40 years that the S phase of the cell cycle is regulated and that parts of the genome are replicated early, while others are replicated late. Numerous studies in the past two decades have revealed that while expressed gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b167f3ba8c0cfa44cdff078e9c2a091c
https://doi.org/10.1007/s004120000080
https://doi.org/10.1007/s004120000080
Autor:
Stefan Schüchner, Erhard Wintersberger
Publikováno v:
Journal of Virology. 73:9266-9273
Although polyomavirus large T antigen readily transactivates S-phase-specific enzymes in serum-starved Swiss 3T3 mouse fibroblasts, it is incapable by itself to efficiently drive such cells into S phase. We describe here that this inability correlate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8cedfb8c33c3cd32e218be1b52f59c7
https://doi.org/10.1128/jvi.73.11.9266-9273.1999
https://doi.org/10.1128/jvi.73.11.9266-9273.1999
Publikováno v:
Journal of Biological Chemistry. 274:30943-30949
Thymidine kinase (TK) genes from different species are growth- and cell cycle-regulated in a very similar manner; still, the promoter regions of these genes show little homology to each other. It was previously shown that the murine TK gene is growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7629ec649e4a753f97c3aec65fcd78
https://doi.org/10.1074/jbc.274.43.30943
https://doi.org/10.1074/jbc.274.43.30943
Autor:
Peter Stiegler, Martin Knöfler, Helmut Dolznig, Wolfgang Mikulits, Ernst W. Müllner, Erhard Wintersberger
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1338:267-274
Using a combination of centrifugal elutriation and recultivation of synchronised cell populations we could show that murine thymidine kinase (TK) is rapidly degraded during mitosis in polyoma virus-transformed mouse fibroblasts, in parallel to the ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1717ff87f59e99484fa8545d0940ecf
https://doi.org/10.1016/s0167-4838(96)00217-8
https://doi.org/10.1016/s0167-4838(96)00217-8
Publikováno v:
Oncogene. 14:987-995
DNA amplification is a readily measurable indicator for genome destabilization. Contrary to normal senescing cells, those of most immortal or transformed cell lines are karyotypically unstable and permissive for amplification. Permissivity for amplif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3398a51bbfbbf6725efe114fd26dfc4
https://doi.org/10.1038/sj.onc.1200904
https://doi.org/10.1038/sj.onc.1200904
Autor:
Egon Ogris, Ernst W. Müllner, E Wawra, Erhard Wintersberger, Martin Knöfler, Markus Hengstschläger
Publikováno v:
Scopus-Elsevier
We compared the cell cycle regulation of thymidine kinase (TK) after centrifugal elutriation in normal human and mouse cells (primary cells, diploid fibroblasts) with its expression in cells transformed with different DNA tumor viruses. Normal cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b045047e41942ac1531c96155fc57113
https://doi.org/10.1016/s0021-9258(17)36723-6
https://doi.org/10.1016/s0021-9258(17)36723-6
Publikováno v:
Molecular and Cellular Biology. 14:1886-1892
Previously constructed Swiss mouse 3T3 fibroblasts producing polyomavirus large T antigen after addition of dexamethasone were used to study the transcriptional activation by the viral protein of five genes coding for enzymes involved in DNA synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304a1c5af5cbe051dd2fdd95868dc184
https://doi.org/10.1128/mcb.14.3.1886
https://doi.org/10.1128/mcb.14.3.1886
Publikováno v:
Journal of Biological Chemistry. 268:11409-11416
We observed that decline of thymidine kinase (TK) enzyme activity was severalfold faster than the decay of full length TK mRNA during growth arrest of 3T6 mouse fibroblasts or during differentiation of myoblasts (C2Cl12) or F9 embryonal carcinoma cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18676d37951e7f32f6c1196a0589472f
https://doi.org/10.1016/s0021-9258(18)82139-1
https://doi.org/10.1016/s0021-9258(18)82139-1
Publikováno v:
Scopus-Elsevier
The promoter of the murine thymidine kinase gene contains a binding site for transcription factor E2F. Using cell lines (3T3-LT) conditionally expressing polyomavirus large T antigen from a hormone-responsive promoter and reporter gene constructs car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192268c2bf58f58da2c954b7e9e4e606
https://doi.org/10.1128/jvi.67.4.1765-1771.1993
https://doi.org/10.1128/jvi.67.4.1765-1771.1993