Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Erhard Hohenester"'
Autor:
Douglas Sammon, Anja Krueger, Marta Busse-Wicher, Rhodri Marc Morgan, Stuart M. Haslam, Benjamin Schumann, David C. Briggs, Erhard Hohenester
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Two major glycosaminoglycan types, heparan sulfate (HS) and chondroitin sulfate (CS), control many aspects of development and physiology in a type-specific manner. HS and CS are attached to core proteins via a common linker tetrasaccharide,
Externí odkaz:
https://doaj.org/article/e93e6f683e98463789b2743a15c05db5
Autor:
Antonio Di Maio, Molly McGrath, Muyuan Niu, Yan Liu, Scott Gardner, Douglas Sammon, Doryen Bubeck, Rhodri Marc Morgan, Erhard Hohenester
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background: Hyaluronic acid (HA) is a major polysaccharide component of the extracellular matrix. HA has essential functions in tissue architecture and the regulation of cell behaviour. HA turnover needs to be finely balanced. Increased HA degradatio
Externí odkaz:
https://doaj.org/article/9db2c6b794e94a3baa901d2f6d86a797
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69833 (2013)
The GFOGER motif in collagens (O denotes hydroxyproline) represents a high-affinity binding site for all collagen-binding integrins. Other GxOGER motifs require integrin activation for maximal binding. The E318W mutant of the integrin α2β1 I domain
Externí odkaz:
https://doaj.org/article/9d1d9f11f659498bb0ecce99ea3115f0
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e42473 (2012)
The heterotrimeric laminins are a defining component of basement membranes and essential for tissue formation and function in all animals. The three short arms of the cross-shaped laminin molecule are composed of one chain each and their tips mediate
Externí odkaz:
https://doaj.org/article/a94702e75eca4a868adae879af45bdde
Autor:
Muyuan Niu, Molly McGrath, Douglas Sammon, Scott Gardner, Rhodri Marc Morgan, Antonio Di Maio, Yan Liu, Doryen Bubeck, Erhard Hohenester
Publikováno v:
Wellcome Open Research. 8:76
Background: Hyaluronic acid (HA) is a major polysaccharide component of the extracellular matrix. HA has essential functions in tissue architecture and the regulation of cell behaviour. HA turnover needs to be finely balanced. Increased HA degradatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291a22b66964002df98624fd9505249c
https://doi.org/10.12688/wellcomeopenres.18937.2
https://doi.org/10.12688/wellcomeopenres.18937.2
Autor:
Muyuan Niu, Molly McGrath, Douglas Sammon, Scott Gardner, Rhodri Marc Morgan, Doryen Bubeck, Erhard Hohenester
Publikováno v:
Wellcome Open Research. 8:76
Background: Hyaluronic acid (HA) is a major polysaccharide component of the extracellular matrix. HA has essential functions in tissue architecture and the regulation of cell behaviour. HA turnover needs to be finely balanced. Increased HA degradatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8103b463a6b590b937e8eaa84797f0f3
https://doi.org/10.12688/wellcomeopenres.18937.1
https://doi.org/10.12688/wellcomeopenres.18937.1
Publikováno v:
Matrix Biol
Laminin polymerization is a key step of basement membrane assembly that depends on the binding of α, β and γ N-terminal LN domains to form a polymer node. Nodal assembly can be divided into two steps consisting of β- and γ-LN dimerization follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e078a73bf1ffd81ac03ab2421f52fe5
https://europepmc.org/articles/PMC8223250/
https://europepmc.org/articles/PMC8223250/
Autor:
Jia Gao, Kefei Yu, Kunli Liu, Xuefei Huang, Setare Tahmasebi Nick, Po Han Lin, Erhard Hohenester
Publikováno v:
Org Biomol Chem
Proteoglycans (PGs) play important roles in many biological processes including tumor progression, cell adhesion, and regulation of growth factor activities. With glycosaminoglycan chains attached to the core proteins in nature, PGs are highly challe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea9098e78edf24046ccb212843dc4eb
http://hdl.handle.net/10044/1/88935
http://hdl.handle.net/10044/1/88935
Publikováno v:
Proc Natl Acad Sci U S A
Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase with important functions in organogenesis and tissue homeostasis. Aberrant DDR1 activity contributes to the progression of human diseases, including fibrosis and canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88fdacb9afcfd4b7a77b08dcb1f28d1
https://pubmed.ncbi.nlm.nih.gov/34155122
https://pubmed.ncbi.nlm.nih.gov/34155122
Publikováno v:
Matrix Biology
Laminins are a major constituent of all basement membranes. The polymerisation of laminins at the cell surface is mediated by the three short arms of the cross-shaped laminin heterotrimer. The short arms contain repeats of laminin-type epidermal grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b606044bd4971049bfd4672eed42d8
https://doi.org/10.1016/j.matbio.2016.06.006
https://doi.org/10.1016/j.matbio.2016.06.006