Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Ergeng Hao"'
Autor:
Emilie Blanchet, Sam Van de Velde, Shigenobu Matsumura, Ergeng Hao, John LeLay, Klaus Kaestner, Marc Montminy
Publikováno v:
Cell Reports, Vol 10, Iss 7, Pp 1149-1157 (2015)
Although persistent elevations in circulating glucose concentrations promote compensatory increases in pancreatic islet mass, unremitting insulin resistance causes deterioration in beta cell function that leads to the progression to diabetes. Here, w
Externí odkaz:
https://doaj.org/article/ad571a5e9c18420384600553b9eef61a
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38721 (2012)
The chemokine receptor CXCR4 and ligand SDF-1α are expressed in fetal and adult mouse islets. Neutralization of CXCR4 has previously been shown to diminish ductal cell proliferation and increase apoptosis in the IFNγ transgenic mouse model in which
Externí odkaz:
https://doaj.org/article/d2ca6eae3e414279a011c467233063b0
Publikováno v:
Cell Transplantation, Vol 5 (1996)
Intraductal distention of the pancreas with collagenase followed by stationary warm incubation improves the recovery of islets of Langerhans in the rat, but controlled studies are needed for valid comparison with standard isolation methods. We have m
Externí odkaz:
https://doaj.org/article/439f8787f60f47b3aae43ba52a4e82a6
Autor:
Pamela Itkin-Ansari, Fred Levine, Andrew Lowy, David J. Shields, James Shapiro, Alice Kiselyuk, Ergeng Hao, Seung-Hee Lee
Pancreatic ductal adenocarcinoma (PDA) has a 5-year survival rate of less than 5%, and therapeutic advances have been hampered by gaps in our understanding of cell-cycle control in the adult pancreas. Previously, we reported that basic Helix-Loop-Hel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13259ddac00e461927de13ad7836b2ee
https://doi.org/10.1158/1541-7786.c.6542097
https://doi.org/10.1158/1541-7786.c.6542097
Signaling via IL1β and TLR4 receptors (IL1R-TLR4) plays a crucial role in cytokine and fatty acid-induced beta cell inflammation, in type 1 and type 2 diabetes respectively. IL1R-TLR4 share signaling mechanisms via a common, cytoplasmic, toll-like-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2137e3485ab7891cf4bd4b1c158aaee8
https://doi.org/10.1101/2022.10.09.511391
https://doi.org/10.1101/2022.10.09.511391
Publikováno v:
Journal of Biological Chemistry. :104803
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c7d39b9c7c9d0cd7be2a2144276af3e
https://doi.org/10.1016/j.jbc.2023.104803
https://doi.org/10.1016/j.jbc.2023.104803
Publikováno v:
Islets. 10:201-212
Recently, we showed that pancreatitis in the context of profound β-cell deficiency was sufficient to induce islet cell transdifferentiation. In some circumstances, this effect was sufficient to result in recovery from severe diabetes. More recently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af4881c995e6f83762f909fe0a6befe
https://doi.org/10.1080/19382014.2018.1472839
https://doi.org/10.1080/19382014.2018.1472839
Autor:
Ergeng Hao, John LeLay, Emilie Blanchet, Sam Van de Velde, Shigenobu Matsumura, Marc Montminy, Klaus H. Kaestner
Publikováno v:
Cell Reports, Vol 10, Iss 7, Pp 1149-1157 (2015)
SummaryAlthough persistent elevations in circulating glucose concentrations promote compensatory increases in pancreatic islet mass, unremitting insulin resistance causes deterioration in beta cell function that leads to the progression to diabetes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f13a14419e9a3197408d704602d647
http://www.sciencedirect.com/science/article/pii/S2211124715000716
http://www.sciencedirect.com/science/article/pii/S2211124715000716
Autor:
Jenny Ma, Claire L. Dubois, Hung Ping Shih, Philip A. Seymour, Janel L. Kopp, Ashleigh E. Schaffer, Maike Sander, Ergeng Hao
Publikováno v:
Development. 138:653-665
One major unresolved question in the field of pancreas biology is whether ductal cells have the ability to generate insulin-producing β-cells. Conclusive examination of this question has been limited by the lack of appropriate tools to efficiently a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70455bb58415f89cc5aa2a2e48ba3f21
https://doi.org/10.1242/dev.056499
https://doi.org/10.1242/dev.056499
Publikováno v:
OBM Transplantation. 3:1-1
Background This presentation of a six-year study processing human islets for research and transplantation includes a review of multi-center transplant studies identifying key variables critical for successful islet processing and defines standardized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b15f0e51ed242b1f67cbc4bce8a3bcf
https://doi.org/10.21926/obm.transplant.1901052
https://doi.org/10.21926/obm.transplant.1901052