Development of a drug delivering round window niche implant for cochlear pharmacotherapy

Autor: Chunjiang Wei, Ziwen Gao, Martina Knabel, Martin Ulbricht, Stefan Senekowitsch, Peter Erfurt, Norman Maggi, Bastian Zwick, Thomas Eickner, Farnaz Matin-Mann, Anne Seidlitz, Thomas Lenarz, Verena Scheper

Publikováno v: Drug Delivery, Vol 31, Iss 1 (2024)

Background There exists an unfulfilled requirement for effective cochlear pharmacotherapy. Controlled local drug delivery could lead to effective bioavailability. The round window niche (RWN), a cavity in the middle ear, is connected to the cochlea v

Externí odkaz: https://doaj.org/article/69350fc3c8084ce3bc83da1bb8f1d31b

Canal-wall up cholesteatoma surgery with mastoid obliteration leads to lower rates of disease recurrence without affecting hearing outcomes

Autor: Chiara Erfurt, Sanne F. Westerhout, Louise V. Straatman, Adriana L. Smit, Robert J. Stokroos, Hans G. X. M. Thomeer

Publikováno v: Frontiers in Surgery, Vol 11 (2024)

ObjectivesThe primary objective was to determine whether obliteration of the epitympanic area and mastoid cavity during canal wall up (CWU) cholesteatoma surgery reduces the rate of recurrent and residual cholesteatoma compared to not obliterating th

Externí odkaz: https://doaj.org/article/b0860d788eaf4c419a35daa3d0235b1c

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Panta Rhei benchmark dataset: socio-hydrological data of paired events of floods and droughts

Autor: H. Kreibich, K. Schröter, G. Di Baldassarre, A. F. Van Loon, M. Mazzoleni, G. W. Abeshu, S. Agafonova, A. AghaKouchak, H. Aksoy, C. Alvarez-Garreton, B. Aznar, L. Balkhi, M. H. Barendrecht, S. Biancamaria, L. Bos-Burgering, C. Bradley, Y. Budiyono, W. Buytaert, L. Capewell, H. Carlson, Y. Cavus, A. Couasnon, G. Coxon, I. Daliakopoulos, M. C. de Ruiter, C. Delus, M. Erfurt, G. Esposito, D. François, F. Frappart, J. Freer, N. Frolova, A. K. Gain, M. Grillakis, J. O. Grima, D. A. Guzmán, L. S. Huning, M. Ionita, M. Kharlamov, D. N. Khoi, N. Kieboom, M. Kireeva, A. Koutroulis, W. Lavado-Casimiro, H.-Y. Li, M. C. LLasat, D. Macdonald, J. Mård, H. Mathew-Richards, A. McKenzie, A. Mejia, E. M. Mendiondo, M. Mens, S. Mobini, G. S. Mohor, V. Nagavciuc, T. Ngo-Duc, H. T. T. Nguyen, P. T. T. Nhi, O. Petrucci, N. H. Quan, P. Quintana-Seguí, S. Razavi, E. Ridolfi, J. Riegel, M. S. Sadik, N. Sairam, E. Savelli, A. Sazonov, S. Sharma, J. Sörensen, F. A. A. Souza, K. Stahl, M. Steinhausen, M. Stoelzle, W. Szalińska, Q. Tang, F. Tian, T. Tokarczyk, C. Tovar, T. V. T. Tran, M. H. J. van Huijgevoort, M. T. H. van Vliet, S. Vorogushyn, T. Wagener, Y. Wang, D. E. Wendt, E. Wickham, L. Yang, M. Zambrano-Bigiarini, P. J. Ward

Publikováno v: Earth System Science Data, Vol 15, Pp 2009-2023 (2023)

As the adverse impacts of hydrological extremes increase in many regions of the world, a better understanding of the drivers of changes in risk and impacts is essential for effective flood and drought risk management and climate adaptation. However,

Externí odkaz: https://doaj.org/article/36aa2c1316c0428fbdfc70d7aba48b34