Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Erez Y Levanon"'
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 4, p e1010923 (2023)
Adenosine-to-inosine RNA editing is essential to prevent undesired immune activation. This diverse process alters the genetic content of the RNA and may recode proteins, change splice sites and miRNA targets, and mimic genomic mutations. Recent studi
Externí odkaz:
https://doaj.org/article/4fc29ed28e8a47918044fd39ea67cf26
Autor:
Adi Avram-Shperling, Eli Kopel, Itamar Twersky, Orshay Gabay, Amit Ben-David, Sarit Karako-Lampert, Joshua J C Rosenthal, Erez Y Levanon, Eli Eisenberg, Shay Ben-Aroya
Publikováno v:
PLoS Genetics, Vol 19, Iss 3, p e1010661 (2023)
The most abundant form of RNA editing in metazoa is the deamination of adenosines into inosines (A-to-I), catalyzed by ADAR enzymes. Inosines are read as guanosines by the translation machinery, and thus A-to-I may lead to protein recoding. The abili
Externí odkaz:
https://doaj.org/article/591564ca4c774ab6b01bc64e9f42b725
Autor:
Mor Hanan, Alon Simchovitz, Nadav Yayon, Shani Vaknine, Roni Cohen‐Fultheim, Miriam Karmon, Nimrod Madrer, Talia Miriam Rohrlich, Moria Maman, Estelle R Bennett, David S Greenberg, Eran Meshorer, Erez Y Levanon, Hermona Soreq, Sebastian Kadener
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 9, Pp 1-19 (2020)
Abstract Circular RNAs (circRNAs) are brain‐abundant RNAs of mostly unknown functions. To seek their roles in Parkinson's disease (PD), we generated an RNA sequencing resource of several brain region tissues from dozens of PD and control donors. In
Externí odkaz:
https://doaj.org/article/59c3dbb994574331815445049bcce8f6
Autor:
Ilana Buchumenski, Osnat Bartok, Reut Ashwal-Fluss, Varun Pandey, Hagit T Porath, Erez Y Levanon, Sebastian Kadener
Publikováno v:
PLoS Genetics, Vol 13, Iss 7, p e1006931 (2017)
In Drosophila, A-to-I editing is prevalent in the brain, and mutations in the editing enzyme ADAR correlate with specific behavioral defects. Here we demonstrate a role for ADAR in behavioral temperature adaptation in Drosophila. Although there is a
Externí odkaz:
https://doaj.org/article/eccc81e6702c4685a8336bb5042662f9
Autor:
Adi Shamay-Ramot, Khen Khermesh, Hagit T Porath, Michal Barak, Yishay Pinto, Chaim Wachtel, Alona Zilberberg, Tali Lerer-Goldshtein, Sol Efroni, Erez Y Levanon, Lior Appelbaum
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005702 (2015)
Fragile X syndrome (FXS) is the most frequent inherited form of mental retardation. The cause for this X-linked disorder is the silencing of the fragile X mental retardation 1 (fmr1) gene and the absence of the fragile X mental retardation protein (F
Externí odkaz:
https://doaj.org/article/a926f0f2ecef4001bfe38aa8dd4fe5dc
Autor:
Shahar Alon, Sandra C Garrett, Erez Y Levanon, Sara Olson, Brenton R Graveley, Joshua J C Rosenthal, Eli Eisenberg
Publikováno v:
eLife, Vol 4 (2015)
RNA editing by adenosine deamination alters genetic information from the genomic blueprint. When it recodes mRNAs, it gives organisms the option to express diverse, functionally distinct, protein isoforms. All eumetazoans, from cnidarians to humans,
Externí odkaz:
https://doaj.org/article/8c30e23d10bf44a8b235ce30ebf7a6e1
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002317 (2011)
Adenosine-to-inosine modification of RNA molecules (A-to-I RNA editing) is an important mechanism that increases transciptome diversity. It occurs when a genomically encoded adenosine (A) is converted to an inosine (I) by ADAR proteins. Sequencing re
Externí odkaz:
https://doaj.org/article/49dcd12e52ea4caa8fd12eccf7af082c
Publikováno v:
PLoS Genetics, Vol 6, Iss 5, p e1000954 (2010)
While it is widely held that an organism's genomic information should remain constant, several protein families are known to modify it. Members of the AID/APOBEC protein family can deaminate DNA. Similarly, members of the ADAR family can deaminate RN
Externí odkaz:
https://doaj.org/article/a85d2d4d5e13428f9f52c85eb9e27268
Publikováno v:
PLoS Genetics, Vol 4, Iss 9, p e1000204 (2008)
Examination of the human transcriptome reveals higher levels of RNA editing than in any other organism tested to date. This is indicative of extensive double-stranded RNA (dsRNA) formation within the human transcriptome. Most of the editing sites are
Externí odkaz:
https://doaj.org/article/0446af7c8b314b089d1abcf9ce822a05
Autor:
Amina Jbara, Kuan-Ting Lin, Chani Stossel, Zahava Siegfried, Haya Shqerat, Adi Amar-Schwartz, Ela Elyada, Maxim Mogilevsky, Maria Raitses-Gurevich, Jared L. Johnson, Tomer M. Yaron, Ofek Ovadia, Gun Ho Jang, Miri Danan-Gotthold, Lewis C. Cantley, Erez Y. Levanon, Steven Gallinger, Adrian R. Krainer, Talia Golan, Rotem Karni
Publikováno v:
Nature. 617:147-153
Pancreatic ductal adenocarcinoma (PDA) is characterized by aggressive local invasion and metastatic spread, leading to high lethality. Although driver gene mutations during PDA progression are conserved, no specific mutation is correlated with the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f46cea7d54cba712f53021047acbf80
https://doi.org/10.1038/s41586-023-05820-3
https://doi.org/10.1038/s41586-023-05820-3