Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Erez Podoly"'
Publikováno v:
Encyclopedia of Molecular Pharmacology ISBN: 9783030215736
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46bce7d0f310f878c070c9f87cf0f35f
https://doi.org/10.1007/978-3-030-21573-6_184-1
https://doi.org/10.1007/978-3-030-21573-6_184-1
Autor:
Hermona Soreq, Oded Livnah, Deborah E. Shalev, Estelle R. Bennett, Erez Podoly, Einor Ben Assayag, Shani Shenhar-Tsarfaty, Harvey Wilgus
Publikováno v:
The Journal of Biological Chemistry
The K variant of butyrylcholinesterase (BChE-K, 20% incidence) is a long debated risk factor for Alzheimer disease (AD). The A539T substitution in BChE-K is located at the C terminus, which is essential both for BChE tetramerization and for its capac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5554c58e9960bcefaec28a24518ff7
http://europepmc.org/articles/PMC2719355
http://europepmc.org/articles/PMC2719355
Autor:
Leticia Schreiber, Hermona Soreq, Inbal Mor, Tsafrir S. Mor, Brian C. Geyer, Ella H. Sklan, Erez Podoly, Dan Grisaru, Marjorie Pick, S. Bar-Sheshet Itach, Marc W. Kirschner, L. Yogev
Publikováno v:
Journal of Cellular and Molecular Medicine
Changes in protein subdomains through alternative splicing often modify protein-protein interactions, altering biological processes. A relevant example is that of the stress-induced up-regulation of the acetylcholinesterase (AChE-R) splice variant, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ff268b2a9e5ca1fde335732495356f
https://doi.org/10.1111/j.1582-4934.2008.00231.x
https://doi.org/10.1111/j.1582-4934.2008.00231.x
Autor:
H. Wilgus, Aryeh Weiss, Naomi Melamed-Book, Hermona Soreq, T. Bruck, Erez Podoly, S. Langermann, Y. Huang, Sophia Diamant, Oded Livnah
Publikováno v:
Neurodegenerative Diseases. 5:232-236
Background: In Alzheimer’s disease (AD), brain butyrylcholinesterase (BChE) co-localizes with β-amyloid (Aβ) fibrils. Aims: In vitro testing of the significance of this phenomenon to AD progress. Methods: A thioflavine T (ThT) fluorogenic assay,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc24a9c6ff97e68e599af05598bc524
https://doi.org/10.1159/000113711
https://doi.org/10.1159/000113711
Autor:
Yun-Yan Xiang, Hermona Soreq, Wei-Yang Lu, Erez Podoly, Keren Ofek, Binyamin Hochner, Noa Farchi, Sophia Diamant, Haiheng Dong, Oded Livnah, Jingxin Li
Publikováno v:
Neurodegenerative Diseases. 4:171-184
Background: Peripheral anionic site (PAS) blockade of acetylcholinesterase (AChE) notably affects neuronal activity and cyto-architecture, however, the mechanism(s) involved are incompletely understood. Objective: We wished to specify the PAS extrace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156c8837940bfd5dcabf6eb97194c0e0
https://doi.org/10.1159/000101842
https://doi.org/10.1159/000101842
Autor:
Oded Livnah, Shai Luria, Yoav Yehezkelli, Liat BenMoyal-Segal, Ariel Hourvitz, Arik Eisenkraft, Boris Bryk, Hermona Soreq, Erez Podoly, Amir Cohen
Publikováno v:
Journal of Neurochemistry. 92:1216-1227
The 5.5 Mb chromosome 7q21-22 ACHE/PON1 locus harbours the ACHE gene encoding the acetylcholine hydrolyzing, organophosphate (OP)-inhibitable acetylcholinesterase protein and the paraoxonase gene PON1, yielding the OP-hydrolyzing PON1 enzyme which al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82b1ace4c65e04918459d7100585ba24
https://doi.org/10.1111/j.1471-4159.2004.02959.x
https://doi.org/10.1111/j.1471-4159.2004.02959.x
Autor:
Hermona Soreq, Erez Podoly, Oded Livnah, Adi Gilboa-Geffen, Assaf Bahat, Uriya Bekenstein, Estelle R. Bennett, Nir Waiskopf, Gunther Hartmann, Keren Ofek
Publikováno v:
Journal of molecular neuroscience : MN. 53(3)
Selective serotonin reuptake inhibitors (SSRIs) show anti-inflammatory effects, suggesting a possible interaction with both Toll-like-receptor 4 (TLR4) responses and cholinergic signaling through as yet unclear molecular mechanism(s). Our results of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c768c943b2c07957c5befb338e4b39a3
https://pubmed.ncbi.nlm.nih.gov/24258317
https://pubmed.ncbi.nlm.nih.gov/24258317
Autor:
Hermona Soreq, Erez Podoly
While cholinesterase inhibitors are used to treat Alzheimer's disease- AD, the Amyloid beta Aβ cascade hypothesis leads to the development of anti-amyloid therapies. Disease-modifying intervention could involve decreasing Aβ production, intervening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::568fb90c1f9558fe2c6d463efdb81dae
https://doi.org/10.1039/9781849731065-00059
https://doi.org/10.1039/9781849731065-00059
Publikováno v:
Chemico-biological interactions. 187(1-3)
Alanine-to-threonine (A to T) substitutions caused by single nucleotide polymorphisms (SNPs) occur in diverse proteins, and in certain cases these substitutions induce self-aggregation into amyloid fibrils or aggregation in other amyloidogenic protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90ee7c6fc4fe4eb487e920999445d888
https://pubmed.ncbi.nlm.nih.gov/20060816
https://pubmed.ncbi.nlm.nih.gov/20060816