Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Erez Dror"'
Autor:
Kaisa Hofwimmer, Joyce de Paula Souza, Narmadha Subramanian, Milica Vujičić, Leila Rachid, Hélène Méreau, Cheng Zhao, Erez Dror, Emelie Barreby, Niklas K. Björkström, Ingrid Wernstedt Asterholm, Marianne Böni-Schnetzler, Daniel T. Meier, Marc Y. Donath, Jurga Laurencikiene
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Postprandial IL-1β surges are predominant in the white adipose tissue (WAT), but its consequences are unknown. Here, we investigate the role of IL-1β in WAT energy storage and show that adipocyte-specific deletion of IL-1 receptor 1 (IL1R1
Externí odkaz:
https://doaj.org/article/ba5db9b693c1401681bcd5953d8aed76
Autor:
Urszula Brykczynska, Marco Geigges, Sophia J. Wiedemann, Erez Dror, Marianne Böni-Schnetzler, Christoph Hess, Marc Y. Donath, Renato Paro
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1627-1643.e7 (2020)
Summary: The innate immune system safeguards the organism from both pathogenic and environmental stressors. Also, physiologic levels of nutrients affect organismal and intra-cellular metabolism and challenge the immune system. In the long term, over-
Externí odkaz:
https://doaj.org/article/54b0b70065bb4546aa8d688de4a57702
Autor:
Marianne Böni-Schnetzler, Stéphanie P. Häuselmann, Elise Dalmas, Daniel T. Meier, Constanze Thienel, Shuyang Traub, Friederike Schulze, Laura Steiger, Erez Dror, Praxedis Martin, Pedro L. Herrera, Cem Gabay, Marc Y. Donath
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1774-1786 (2018)
Summary: Interleukin-1 receptor antagonist (IL-1Ra) is elevated in the circulation during obesity and type 2 diabetes (T2D) but is decreased in islets from patients with T2D. The protective role of local IL-1Ra was investigated in pancreatic islet β
Externí odkaz:
https://doaj.org/article/57e70e42c68f4540a15c19f5916584e6
Autor:
Thierry M. Nordmann, Erez Dror, Friederike Schulze, Shuyang Traub, Ekaterine Berishvili, Charlotte Barbieux, Marianne Böni-Schnetzler, Marc Y. Donath
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Chronic inflammation impairs insulin secretion and sensitivity. β-cell dedifferentiation has recently been proposed as a mechanism underlying β-cell failure in T2D. Yet the effect of inflammation on β-cell identity in T2D has not been stu
Externí odkaz:
https://doaj.org/article/6f906ade44424de0a8b12cce0ea33f04
Autor:
Shuyang Traub, Daniel T. Meier, Friederike Schulze, Erez Dror, Thierry M. Nordmann, Nicole Goetz, Norina Koch, Elise Dalmas, Marc Stawiski, Valmir Makshana, Fabrizio Thorel, Pedro L. Herrera, Marianne Böni-Schnetzler, Marc Y. Donath
Publikováno v:
Cell Reports, Vol 18, Iss 13, Pp 3192-3203 (2017)
Pancreatic α cells may process proglucagon not only to glucagon but also to glucagon-like peptide-1 (GLP-1). However, the biological relevance of paracrine GLP-1 for β cell function remains unclear. We studied effects of locally derived insulin sec
Externí odkaz:
https://doaj.org/article/bf5e8dc8466046d0b86cc1980531f5c0
Autor:
Anne Drougard, Eric H Ma, Vanessa Wegert, Ryan Sheldon, Ilaria Panzeri, Naman Vatsa, Stefanos Apostle, Luca Fagnocchi, Judith Schaf, Klaus Gossens, Josephine Völker, Shengru Pang, Anna Bremser, Erez Dror, Francesca Giacona, null Sagar, Michael X Henderson, Marco Prinz, Russell G Jones, J. Andrew Pospisilik
Chronic high-fat feeding triggers widespread metabolic dysfunction including obesity, insulin resistance, and diabetes. While these ultimate pathological states are relatively well understood, we have a limited understanding of how high-fat intake fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f396eac4320c577d48d58931e1d889c2
https://doi.org/10.1101/2023.04.03.535373
https://doi.org/10.1101/2023.04.03.535373
Autor:
Erez Dror, Luca Fagnocchi, Vanessa Wegert, Stefanos Apostle, Brooke Grimaldi, Tim Gruber, Ilaria Panzeri, Steffen Heyne, Kira Daniela Höffler, Victor Kreiner, Reagan Ching, Tess Tsai-Hsiu Lu, Ayush Semwal, Ben Johnson, Parijat Senapati, Adelheid M. Lempradl, Dustin Schones, Axel Imhof, Hui Shen, John Andrew Pospisilik
SummaryDespite the recent explosion in surveys of cell-type heterogeneity, the mechanisms that specify and stabilize highly related cell subtypes remain poorly understood. Here, focusing initially on exploring quantitative histone mark heterogeneity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7028eb9f51ed045ac9f9fec222983a4d
https://doi.org/10.1101/2023.01.31.526222
https://doi.org/10.1101/2023.01.31.526222
Autor:
Erez Dror, Marc Y. Donath, Hélène Méreau, Friederike Schulze, Kelly Trimigliozzi, Stéphanie P. Häuselmann, Marianne Böni-Schnetzler, Daniel T. Meier, Marc Stawiski, Leila Rachid, Jose Alberto Molina-Tijeras, Sophia J. Wiedemann, Christelle Le Foll, Christophe Magnan
The initial cephalic phase of insulin secretion is mediated through the vagus nerve and is not due to glycemic stimulation of pancreatic β-cells. Recently, IL-1β was shown to stimulate postprandial insulin secretion. Here, we describe that this inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb406ec06f7a686f45298c77bee55f2
https://www.zora.uzh.ch/id/eprint/211022/
https://www.zora.uzh.ch/id/eprint/211022/
Autor:
Kelly Trimigliozzi, Marianne Boeni-Schnetzler, Daniel T. Meier, Erez Dror, Sophia J. Wiedemann, Theresa V. Rohm, Friederike Schulze, Jose Alberto Molina-Tijeras, Hélène Méreau, Marc Y. Donath, Leila Rachid, Christophe Magnan, Stéphanie P. Häuselmann
Publikováno v:
Diabetes. 69
The non-glucose dependent spike in insulin levels immediately following the beginning of a meal is called the cephalic or pre-absorptive phase of insulin secretion. Even though this early insulin response is of marked consequence for overall postpran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f29f4b09a705f7f2cf34e9e868da550
https://doi.org/10.2337/db20-1955-p
https://doi.org/10.2337/db20-1955-p
Autor:
Friederike, Schulze, Josua, Wehner, Denise V, Kratschmar, Valmir, Makshana, Daniel T, Meier, Stéphanie P, Häuselmann, Elise, Dalmas, Constanze, Thienel, Erez, Dror, Sophia J, Wiedemann, Shuyang, Traub, Thierry M, Nordmann, Leila, Rachid, Axel, De Baat, Theresa V, Rohm, Cheng, Zhao, Alex, Odermatt, Marianne, Böni-Schnetzler, Marc Y, Donath
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Gestational diabetes mellitus (GDM) is one of the most common diseases associated with pregnancy, however, the underlying mechanisms remain unclear. Based on the well documented role of inflammation in type 2 diabetes, the aim was to investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976405532cde1a3d3d9ec6e2c0b3848a