Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Erdmann, Rapp"'
Autor:
Katharina Böttinger, Christof Regl, Veronika Schäpertöns, Erdmann Rapp, Therese Wohlschlager, Christian G. Huber
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 14, Iss 10, Pp 100982- (2024)
Glycans associated with biopharmaceutical drugs play crucial roles in drug safety and efficacy, and therefore, their reliable detection and quantification is essential. Our study introduces a multi-level quantification approach for glycosylation anal
Externí odkaz:
https://doaj.org/article/20e977f3b5274a2b8fd2ccb8448343ed
Publikováno v:
Engineering, Vol 26, Iss , Pp 132-150 (2023)
As the roles of glycans in health and disease continue to be unraveled, it is becoming apparent that glycans’ immense complexity cannot be ignored. To fully delineate glycan structures, we developed an integrative approach combining a set of cost-e
Externí odkaz:
https://doaj.org/article/79d6f955893c4879851bc7d1e77f8b07
Autor:
Irena Trbojević-Akmačić, Frano Vučković, Tea Pribić, Marija Vilaj, Urh Černigoj, Jana Vidič, Jelena Šimunović, Agnieszka Kępka, Ivana Kolčić, Lucija Klarić, Mislav Novokmet, Maja Pučić-Baković, Erdmann Rapp, Aleš Štrancar, Ozren Polašek, James F. Wilson, Gordan Lauc
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
A large-scale comparative study in two human populations analyzes human plasma transferrin and immunoglobulin G (IgG) N-glycosylation profiles and their association with age, sex, and various biochemical and physiological traits.
Externí odkaz:
https://doaj.org/article/0fd38750071a425299f347703d4524e0
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Cell-free, chemoenzymatic platforms are emerging technologies towards generating glycoconjugates with defined and homogeneous glycoforms. Recombinant oligosaccharyltransferases can be applied to glycosylate “empty,” i.e., aglycosyalted, peptides
Externí odkaz:
https://doaj.org/article/ba31a40102ac4ef48f2086b0ef6fcbdf
Autor:
Andrew C. Tolonen, Nicholas Beauchemin, Charlie Bayne, Lingyao Li, Jie Tan, Jackson Lee, Brian M. Meehan, Jeffrey Meisner, Yves Millet, Gabrielle LeBlanc, Robert Kottler, Erdmann Rapp, Chris Murphy, Peter J. Turnbaugh, Geoffrey von Maltzahn, Christopher M. Liu, Johan E. T. van Hylckama Vlieg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Here, the authors characterize the gut microbiome fermentation properties and therapeutic potential of chemically diverse synthetic glycans (SGs), showing they promote specific shifts in taxonomic and metabolite profiles, and exhibit therapeutic bene
Externí odkaz:
https://doaj.org/article/fdaecafadbf44772b429bb30c4ca1053
Autor:
Arthur Hinterholzer, Jennifer Moises, Christof Regl, Sebastian Schwap, Erdmann Rapp, Christian G. Huber, Mario Schubert
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
The α-Gal epitope consisting of the terminal trisaccharide Galα1,3Galβ1,4GlcNAc exposed on cell or protein surfaces can cause severe immune reactions, such as hypersensitivity reactions, in humans. This epitope is also called the xenotransplantati
Externí odkaz:
https://doaj.org/article/d2a62006075448058a90ce5647d9d10a
Autor:
Léa Chuzel, Samantha L. Fossa, Madison L. Boisvert, Samanta Cajic, René Hennig, Mehul B. Ganatra, Udo Reichl, Erdmann Rapp, Christopher H. Taron
Publikováno v:
Microbial Cell Factories, Vol 20, Iss 1, Pp 1-17 (2021)
Abstract Background Sulfate modification of N-glycans is important for several biological functions such as clearance of pituitary hormones or immunoregulation. Yet, the prevalence of this N-glycan modification and its functions remain largely unexpl
Externí odkaz:
https://doaj.org/article/23378c5ccb8e488faa63d8ccb97cde6c
Autor:
Kia Joo Puan, Boris San Luis, Nurhashikin Yusof, Dilip Kumar, Anand Kumar Andiappan, Wendy Lee, Samanta Cajic, Dragana Vuckovic, Jing De Chan, Tobias Döllner, Han Wei Hou, Yunxuan Jiang, Chao Tian, the 23andMe Research Team, Erdmann Rapp, Michael Poidinger, De Yun Wang, Nicole Soranzo, Bernett Lee, Olaf Rötzschke
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Puan and San Luis et al. find that FUT6, encoding a fucosyltransferase, is required for the “rolling” behavior of certain white blood cells that enables them to move from blood vessels to tissues. They show that FUT6 deficiency leads to a loss of
Externí odkaz:
https://doaj.org/article/c143d737821c4b528b01c70d7893f2f4
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Here, we present for the first time, a site-specific N-glycosylation analysis of proteins from a Brazilian Zika virus (ZIKV) strain. The virus was propagated with high yield in an embryo-derived stem cell line (EB66, Valneva SE), and concent
Externí odkaz:
https://doaj.org/article/22d1a00117f2457d84ccc5377000bc89
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/b8689c4c6d90448f8e050b27a1073d6d