Lack of APLP1 leads to subtle alterations in neuronal morphology but does not affect learning and memory

Autor: Erdinger, Susanne, Amrein, Irmgard, Back, Michaela, Ludewig, Susann, Korte, Martin, von Engelhardt, Jakob, Wolfer, David P, Müller, Ulrike C

Publikováno v: Frontiers in Molecular Neuroscience, 15

The amyloid precursor protein APP plays a crucial role in Alzheimer pathogenesis. Its physiological functions, however, are only beginning to be unraveled. APP belongs to a small gene family, including besides APP the closely related amyloid precurso

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https://hdl.handle.net/20.500.11850/582965

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Lack of APLP1 leads to subtle alterations in neuronal morphology but does not affect learning and memory.

Autor: Erdinger S; Department of Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany., Amrein I; Institute of Anatomy, University of Zurich and Institute of Human Movement Sciences, ETH Zurich, Zurich, Switzerland., Back M; Institute of Pathophysiology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Ludewig S; Zoological Institute, Division of Cellular Neurobiology, TU Braunschweig, Braunschweig, Germany., Korte M; Zoological Institute, Division of Cellular Neurobiology, TU Braunschweig, Braunschweig, Germany.; Helmholtz Centre for Infection Research, AG NIND, Braunschweig, Germany., von Engelhardt J; Institute of Pathophysiology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Wolfer DP; Institute of Anatomy, University of Zurich and Institute of Human Movement Sciences, ETH Zurich, Zurich, Switzerland.; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland., Müller UC; Department of Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.

Publikováno v: Frontiers in molecular neuroscience [Front Mol Neurosci] 2022 Oct 28; Vol. 15, pp. 1028836. Date of Electronic Publication: 2022 Oct 28 (Print Publication: 2022).