Výsledky vyhledávání - "Erdem Kamil Ozer"

Protective Effects of Biochanin A against Methotrexate-Induced Acute Liver Injury in Rats

Autor: Erdem Kamil Ozer, Mustafa Tugrul Goktas, Aysun Toker, Ceyhan Ugurluoglu, Hulagu Bariskaner

Publikováno v: Indian Journal of Pharmaceutical Education and Research. 51:741-746

WOS: 000435144400029
Background: Methotrexate (MTX) is one of the most commonly used chemotherapeutic agents in the treatment of cancer patients, however its therapeutic use is limited due to dose dependent hepatotoxicity caused by oxidative dam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ecccdb497713a149bb9f40a5c8c4ba6
https://doi.org/10.5530/ijper.51.4s.107

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Thymoquinone protects against the sepsis induced mortality, mesenteric hypoperfusion, aortic dysfunction and multiple organ damage in rats

Autor: Hulagu Bariskaner, Mustafa Tugrul Goktas, Alper B. Iskit, Ceyhan Ugurluoglu, Aysun Toker, Erdem Kamil Ozer, Sultan Pehlivan

Publikováno v: Pharmacological Reports. 69:683-690

Background Thymoquinone (TQ) is a potent cytoprotective, antioxidant and anti-inflammatory agent. We aimed to investigate the possible protective effects of TQ on survival, mesenteric artery blood flow (MABF), vascular reactivity, oxidative and infla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676e8150b0613b74ddbb94325fc4e6f9
https://doi.org/10.1016/j.pharep.2017.02.021

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Synthesis of fused 1,4-dihydropyridines as potential calcium channel blockers

Autor: Rahime Şimşek, Alper B. Iskit, Ahmed El-Khouly, Miyase Gözde Gündüz, Erdem Kamil Ozer, Cihat Şafak, Yildirim Sara

Publikováno v: Turkish Journal of Biochemistry. 43:578-586

Objective The aim of this study was to synthesize ten 1,4-dihydropyridine (DHP) derivatives in which substituted cyclohexane rings were fused to the DHP ring and to determine how different ester groups and the benzoyl substituent introduced in 4-phen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::086a440f284e1feff65d314da4bbff0e
https://doi.org/10.1515/tjb-2016-0247

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Effects of Carvacrol on Survival, Mesenteric Blood Flow, Aortic Function and Multiple Organ Injury in a Murine Model of Polymicrobial Sepsis

Autor: Ceyhan Ugurluoglu, Alper B. Iskit, Aysun Toker, Hulagu Bariskaner, Erdem Kamil Ozer, Mustafa Tugrul Goktas

Publikováno v: Inflammation. 40(5)

Carvacrol (CRV) has strong cytoprotective, antioxidant, and anti-inflammatory properties. We aimed to demonstrate the possible protective effects of CRV on survival, mesenteric artery blood flow (MBF), vascular reactivity, and oxidative and inflammat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba5f0da9f2e7470bac8a8f16a9c061c
https://pubmed.ncbi.nlm.nih.gov/28646428

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Coenzyme Q10 improves the survival, mesenteric perfusion, organs and vessel functions in septic rats

Autor: Alper B. Iskit, Erdem Kamil Ozer, Hulagu Bariskaner, Mustafa Tugrul Goktas, Ceyhan Ugurluoglu, Ibrahim Kilinc, Sultan Pehlivan

Publikováno v: Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 91

Background Coenzyme Q10 (CoQ10) is a naturally occurring, lipid-soluble antioxidant and an essential electron carrier in the mitochondrial respiratory chain. In sepsis, CoQ10 deficiency induced by mitochondrial failure can lead to hypoxia, hypoperfus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eeba300b3a9531332fbb0b51d7a611a
https://pubmed.ncbi.nlm.nih.gov/28501779

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Infliximab alleviates the mortality, mesenteric hypoperfusion, aortic dysfunction, and multiple organ damage in septic rats

Autor: Ceyhan Ugurluoglu, Alper B. Iskit, Erdem Kamil Ozer, Hulagu Bariskaner, Mustafa Tugrul Goktas, Ibrahim Kilinc, Aysun Toker

WOS: 000404738500012
PubMed: 28459157
Tumor necrosis factor-alpha (TNF-alpha) is a pivotal mediator that triggers inflammatory process, oxidative stress, and multiple organ injury in sepsis. We investigated the effects of infliximab on surv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e5bfcc2700a044032a97eac98411919
https://hdl.handle.net/20.500.12395/35206

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Celecoxib administration reduced mortality, mesenteric hypoperfusion, aortic dysfunction and multiple organ injury in septic rats

Autor: Alper B. Iskit, Erdem Kamil Ozer, Ibrahim Kilinc, Ceyhan Ugurluoglu, Mustafa Tugrul Goktas, Hulagu Bariskaner

Publikováno v: Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 86

Background The cyclooxygenase (COX)-2 overexpression is associated with vascular injury and multiple organ failure in sepsis. However, constitutive COX-1 and basal COX-2 expressions have physiological effects. We aimed to investigate the effects of p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d188961b984b283519ce98ea659587
https://pubmed.ncbi.nlm.nih.gov/28024294

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Investigation of 1377C/T polymorphism of the Toll-like receptor 3 among patients with chronic hepatitis B

Autor: Cemal Bulut, Ali Pekcan Demiröz, Emine Fırat Göktaş, Erdem Kamil Ozer, Atilla Bozkurt, Ragip Ozgur Karaca, Sami Kinikli, Mustafa Tugrul Goktas

Publikováno v: Canadian journal of microbiology. 62(7)

WOS: 000378785100009
PubMed: 27314608
The immunopathogenesis of chronic hepatitis B (CHB) has not been clarified yet. Toll-like receptors (TLR) are a receptor family that initiates immunity with exogenous-endogenous ligands and plays a role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a62c59408c40e26e64802608950f0f
https://pubmed.ncbi.nlm.nih.gov/27314608

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Microwave-assisted synthesis of condensed 1,4-dihydropyridines as potential calcium channel modulators

Autor: Osman Cihat Şafak, Rahime Şimşek, Mehmet Yildirim Sara, Alper B. Iskit, Ahmed El-Khouly, Miyase Gözde Gündüz, Erdem Kamil Ozer

Publikováno v: Volume: 39, Issue: 4
Turkish Journal of Chemistry

WOS: 000359063900017
This study reports the design, synthesis, and calcium channel modulatory activity evaluation of a series of 14 novel fused 1,4-dihydropyridine derivatives. The molecular design of the compounds was based on modifications of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7905a2ac4cd1d50532edf521aa1877
https://dergipark.org.tr/tr/pub/tbtkchem/issue/11969/143372

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Effects of endothelin and nitric oxide on cardiac muscle functions in experimental septic shock model

Autor: Alper B. Iskit, Erdem Kamil Ozer

Publikováno v: Humanexperimental toxicology. 35(3)

We aimed to investigate the possible roles of nitric oxide (NO) and endothelin on the changes of cardiac muscle function in both hyper- and hypodynamic septic shock periods. Cecal ligation and puncture was performed in 50 Wistar albino rats to induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed23ba7e69a48ad60b5035592eb2497
https://pubmed.ncbi.nlm.nih.gov/25911090

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