Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Ercument Dirice"'
Autor:
Giorgio Basile, Sevim Kahraman, Ercument Dirice, Hui Pan, Jonathan M. Dreyfuss, Rohit N. Kulkarni
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)
Abstract Background Human pancreatic islets are a central focus of research in metabolic studies. Transcriptomics is frequently used to interrogate alterations in cultured human islet cells using single-cell RNA-sequencing (scRNA-seq). We introduce s
Externí odkaz:
https://doaj.org/article/0a2587f053b54f06ac12b83d0434a5c0
Autor:
Ercument Dirice, Giorgio Basile, Sevim Kahraman, Danielle Diegisser, Jiang Hu, Rohit N. Kulkarni
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Adaptation to increased insulin demand is mediated by β cell proliferation and neogenesis, among other mechanisms. Although it is known that pancreatic β cells can arise from ductal progenitors, these observations have been limited mostly to the ne
Externí odkaz:
https://doaj.org/article/b5b54765f6be496aa5205bd9295767c8
Autor:
Sara McEwan, Hyokjoon Kwon, Azeddine Tahiri, Nivetha Shanmugarajah, Weikang Cai, Jin Ke, Tianwen Huang, Ariana Belton, Bhagat Singh, Le Wang, Zhiping P. Pang, Ercument Dirice, Esteban A. Engel, Abdelfattah El Ouaamari
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101260- (2021)
The regulation of glucose-stimulated insulin secretion and glucose excursion has a sensory component that operates in a sex-dependent manner. Objective: Here, we aim to dissect the basis of the sexually dimorphic interaction between sensory neurons a
Externí odkaz:
https://doaj.org/article/b1932313dd8b46179d8419c5c30caf62
Autor:
Joey Bou Karam, Weikang Cai, Rowaida Mohamed, Tianwen Huang, Lingqiong Meng, Erica Paige Homan, Ercument Dirice, C. Ronald Kahn, Abdelfattah El Ouaamari
Publikováno v:
Molecular Metabolism, Vol 18, Iss , Pp 60-67 (2018)
There is emerging evidence to support an important role for the transient receptor potential vanilloid type 1 (TRPV1) sensory innervation in glucose homeostasis. However, it remains unknown whether the glucoregulatory action of these afferent neurons
Externí odkaz:
https://doaj.org/article/f6deefe5bad04155b84acff9983e4e2c
Autor:
Ana Barbara Alves-Wagner, Kristin I Stanford, Noah B Prince, Kawai So, Joram D Mul, Ercument Dirice, Michael F Hirshman, Rohit N Kulkarni, Laurie J Goodyear
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
ObjectivePoor maternal and paternal environments increase the risk for obesity and diabetes in offspring, whereas maternal and paternal exercise in mice can improve offspring metabolic health. We determined the effects of combined maternal and patern
Externí odkaz:
https://doaj.org/article/5e83270f70b5476c882a997a57346fc1
Autor:
Ivan Achel Valdez, Ercument Dirice, Manoj K. Gupta, Jun Shirakawa, Adrian Kee Keong Teo, Rohit N. Kulkarni
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 460-470 (2016)
A major goal of diabetes research is to develop strategies that replenish pancreatic insulin-producing beta cells. One emerging strategy is to harness pancreatic plasticity—the ability of pancreatic cells to undergo cellular interconversions—a ph
Externí odkaz:
https://doaj.org/article/3d2426a03aae4b6a9b2a66231d7daf18
Autor:
Adrian Kee Keong Teo, Hwee Hui Lau, Ivan Achel Valdez, Ercument Dirice, Erling Tjora, Helge Raeder, Rohit N. Kulkarni
Publikováno v:
Stem Cell Reports, Vol 6, Iss 3, Pp 357-367 (2016)
Patients with an HNF1BS148L/+ mutation (MODY5) typically exhibit pancreatic hypoplasia. However, the molecular mechanisms are unknown due to inaccessibility of patient material and because mouse models do not fully recapitulate MODY5. Here, we differ
Externí odkaz:
https://doaj.org/article/1e50b8eeb0db4aaa9af14fea5adde2e2
Publikováno v:
Stem Cell Reports, Vol 3, Iss 1, Pp 5-14 (2014)
There is considerable interest in differentiating human pluripotent stem cells (hPSCs) into definitive endoderm (DE) and pancreatic cells for in vitro disease modeling and cell replacement therapy. Numerous protocols use fetal bovine serum, which con
Externí odkaz:
https://doaj.org/article/a2f308cf4e9c4c66951f15b8b5e5a7a7
Autor:
Abdelfattah El Ouaamari, Dan Kawamori, Ercument Dirice, Chong Wee Liew, Jennifer L. Shadrach, Jiang Hu, Hitoshi Katsuta, Jennifer Hollister-Lock, Wei-Jun Qian, Amy J. Wagers, Rohit N. Kulkarni
Publikováno v:
Cell Reports, Vol 3, Iss 2, Pp 401-410 (2013)
Integrative organ crosstalk regulates key aspects of energy homeostasis, and its dysregulation may underlie metabolic disorders such as obesity and diabetes. To test the hypothesis that crosstalk between the liver and pancreatic islets modulates β c
Externí odkaz:
https://doaj.org/article/bf6ed007b2414bab9f248d15d7042116
Autor:
Sakib Hossain, Ankit Gilani, Jonathan Pascale, Elizabeth Villegas, Danielle Diegisser, Kevin Agostinucci, Melissa‐Maria Kulaprathazhe, Ercument Dirice, Victor Garcia, Michal Laniado Schwartzman
Publikováno v:
Obesity. 31:1024-1037
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::437be555a5c1d35e5188f332f790ee85
https://doi.org/10.1002/oby.23692
https://doi.org/10.1002/oby.23692