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Nucleoside-5′-phosphorothioate analogues are biocompatible antioxidants dissolving efficiently amyloid beta–metal ion aggregates

Autor: Yael Nadel, Bilha Fischer, Eran Shmuel, Rostislav Zagalsky, Aviran Amir, Alon Haim Sayer

Publikováno v: Dalton Transactions. 41:8539

Amyloid beta (Aβ) peptide is known to precipitate and form aggregates with zinc and copper ions in vitro and, in vivo in Alzheimer's disease (AD) patients. Metal-ion-chelation was suggested as therapy for the metal-ion-induced Aβ aggregation, metal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44be134284a5bcd461e687d22214979e
https://doi.org/10.1039/c2dt30631j

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