Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Eran Schmukler"'
Autor:
Keren E. Shapira, Guy Shapira, Eran Schmukler, Metsada Pasmanik-Chor, Noam Shomron, Ronit Pinkas-Kramarski, Yoav I. Henis, Marcelo Ehrlich
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract Perturbations to cellular homeostasis, including reduction of the cholesterol level, induce autophagy, a self-digestion process of cellular constituents through an autophagosomal–lysosomal pathway. In accord with its function as a membrane
Externí odkaz:
https://doaj.org/article/1e0f1e6802094b0e812140a0eefb8e1f
Autor:
Eran Schmukler, Ronit Pinkas-Kramarski
Publikováno v:
Advances in Cancer Biology - Metastasis, Vol 3, Iss , Pp 100014- (2021)
Autophagy is an evolutionary conserved process of self-degradation and turnover of cellular components. The role of autophagy in human diseases is complexed as it can promote or inhibit disease progression. In cancer, autophagy can be detrimental or
Externí odkaz:
https://doaj.org/article/246a4353ec46418e85dae627819ff69e
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171351 (2017)
High percentage of human cancers involves alteration or mutation in Ras proteins, including the most aggressive malignancies, such as lung, colon and pancreatic cancers. FTS (Salirasib) is a farnesylcysteine mimetic, which acts as a functional Ras in
Externí odkaz:
https://doaj.org/article/bb519697f58c40e08bc4141b7692856b
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36828 (2012)
Growth factors activating the ErbB receptors have been described in prostate tumors. The androgen dependent prostate cancer cell line, LNCaP, expresses the ErbB-1, ErbB-2 and ErbB-3 receptor tyrosine kinases. Previously, it was demonstrated that NRG
Externí odkaz:
https://doaj.org/article/fd6b22a996de49d1859459581e112d3e
Autor:
Eran Schmukler, Ronit Pinkas-Kramarski
Publikováno v:
Drug Development Research. 81:184-193
A growing body of evidence indicates that autophagy, an intracellular degradation pathway, profoundly affects Alzheimer's disease (AD) pathogenesis. Autophagy mediates the degradation of neurotoxic material and damaged organelles, allowing their clea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b49de78d08fda6f894969ce895d8f4
https://doi.org/10.1002/ddr.21605
https://doi.org/10.1002/ddr.21605
Autor:
Eliezer Masliah, Shira Simonovitch, Ronit Pinkas-Kramarski, Eran Schmukler, Daniel M. Michaelson
Publikováno v:
J Alzheimers Dis
This study examined the effects of apolipoprotein E4 (APOE4), the most prevalent genetic risk factor for Alzheimer’s disease (AD), on proteins involved in mitochondrial dynamics and autophagy, in the hippocampus of targeted replacement mice. Immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df43dbde02d18aa2f006bfc2d42a7c8
https://doi.org/10.3233/jad-190074
https://doi.org/10.3233/jad-190074
Autor:
Shira Solomon, Eya Wolfson, Shira Simonovitch, Daniel M. Michaelson, Eran Schmukler, Yona Goldshmit, Ronit Pinkas-Kramarski
Publikováno v:
Cell Death and Disease, Vol 11, Iss 7, Pp 1-13 (2020)
Cell Death & Disease
Cell Death & Disease
APOE4 is a major risk factor for sporadic Alzheimer’s disease; however, it is unclear how it exerts its pathological effects. Others and we have previously shown that autophagy is impaired in APOE4 compared to APOE3 astrocytes, and demonstrated dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d086d67a79e48a92e5ef911b589e3d8a
https://doi.org/10.1038/s41419-020-02776-4
https://doi.org/10.1038/s41419-020-02776-4
Publikováno v:
Journal of Neurochemistry. 143:584-594
Parkinson's disease (PD) is a progressive neurodegenerative disorder, of which 1% of the hereditary cases are linked to mutations in DJ-1, an oxidative stress sensor. The pathological hallmark of PD is intercellular inclusions termed Lewy Bodies, com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1280bcae87c10e9d97d8089c5c203e
https://doi.org/10.1111/jnc.14222
https://doi.org/10.1111/jnc.14222
Autor:
Dan Frenkel, Eran Schmukler, Eliezer Masliah, Alina Bespalko, Ronit Pinkas-Kramarski, Danny M. Michaelson, Shira Simonovitch, David M. Holtzman, Tal Iram
Publikováno v:
Journal of Alzheimer's Disease. 51:915-927
Alzheimer's disease (AD) is the most prevalent form of dementia in elderly. Genetic studies revealed allelic segregation of the apolipoprotein E (ApoE) gene in sporadic AD and in families with higher risk of AD. The mechanisms underlying the patholog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee7065ddbab4ec214cbfca723d761bc
https://doi.org/10.3233/jad-151101
https://doi.org/10.3233/jad-151101
Autor:
Angela Ruban, Shira Solomon, Ronit Pinkas-Kramarski, Yona Goldshmit, Eran Schmukler, Ghil Jona
Publikováno v:
Journal of neurotrauma. 35(21)
Neurotrauma causes immediate elevation of extracellular glutamate (Glu) levels, which creates excitotoxicity and facilitates inflammation, glial scar formation, and consequently neuronal death. Finding factors that reduce the inflammatory response an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b16f6fcac643ac8d02fca156ba28d97
https://pubmed.ncbi.nlm.nih.gov/29495919
https://pubmed.ncbi.nlm.nih.gov/29495919