Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Eran R. Andrechek"'
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-18 (2024)
Abstract Background The cell cycle of mammary stem cells must be tightly regulated to ensure normal homeostasis of the mammary gland to prevent abnormal proliferation and susceptibility to tumorigenesis. The atypical cell cycle regulator, Spy1 can ov
Externí odkaz:
https://doaj.org/article/e4c3d68de77e45d2933015a7fbff40ad
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-24 (2023)
Abstract Background Breast cancer is a complex and heterogeneous disease with distinct subtypes and molecular profiles corresponding to different clinical outcomes. Mouse models of breast cancer are widely used, but their relevance in capturing the h
Externí odkaz:
https://doaj.org/article/6095c0bac29e441ebd75d3415f4fcda9
Autor:
Matthew R Swiatnicki, Jonathan P Rennhack, Mylena M O Ortiz, Daniel P Hollern, Ashlee V Perry, Rachel Kubiak, Sarai M Riveria Riveria, Sandra O'Reilly, Eran R Andrechek
Publikováno v:
PLoS Genetics, Vol 18, Iss 9, p e1010362 (2022)
The role of EGFR in lung cancer is well described with numerous activating mutations that result in phosphorylation and tyrosine kinase inhibitors that target EGFR. While the role of the EGFR kinase in non-small cell lung cancer (NSCLC) is appreciate
Externí odkaz:
https://doaj.org/article/803ec9957ab743e9ab0f4a7a00cdb9a8
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The E2F family of transcription factors is important for many cellular processes, from their canonical role in cell cycle regulation to other roles in angiogenesis and metastasis. Alteration of the Rb/E2F pathway occurs in various forms of c
Externí odkaz:
https://doaj.org/article/cd3d8c51cc584568b05e926126d6c529
Autor:
Jonathan P. Rennhack, Briana To, Matthew Swiatnicki, Caleb Dulak, Martin P. Ogrodzinski, Yueqi Zhang, Caralynn Li, Evan Bylett, Christina Ross, Karol Szczepanek, William Hanrahan, Muthu Jayatissa, Sophia Y. Lunt, Kent Hunter, Eran R. Andrechek
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Mouse models are an essential tool in breast cancer research. Here, the authors present the genomic and transcriptomic profiles of two widely used mouse models, revealing parallels with the human disease specifically with metastasis and treatment res
Externí odkaz:
https://doaj.org/article/36cd74040a764c95a84c39189bb4072a
Autor:
Harvey W. Smith, Alison Hirukawa, Virginie Sanguin-Gendreau, Ipshita Nandi, Catherine R. Dufour, Dongmei Zuo, Kristofferson Tandoc, Matthew Leibovitch, Salendra Singh, Jonathan P. Rennhack, Matthew Swiatnicki, Cynthia Lavoie, Vasilios Papavasiliou, Carolin Temps, Neil O. Carragher, Asier Unciti-Broceta, Paul Savage, Mark Basik, Vincent van Hoef, Ola Larsson, Caroline L. Cooper, Ana Cristina Vargas Calderon, Jane Beith, Ewan Millar, Christina Selinger, Vincent Giguère, Morag Park, Lyndsay N. Harris, Vinay Varadan, Eran R. Andrechek, Sandra A. O’Toole, Ivan Topisirovic, William J. Muller
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Polycomb Repressor Complex 2 (PRC2) is frequently up-regulated in cancers. Here, the authors show that the tyrosine kinase c-Src stimulates mitochondrial function to signal energy sufficiency to mTORC1, increasing translation of the PRC2 subunits EZH
Externí odkaz:
https://doaj.org/article/4b4ac9959bb3404bb739e2634c53409f
Autor:
Ke Liu, Patrick A. Newbury, Benjamin S. Glicksberg, William Z. D. Zeng, Shreya Paithankar, Eran R. Andrechek, Bin Chen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
While cell lines and organoids are extensively used to study cancer, how closely they resemble the disease in patients remains unclear. Here, Liu et al. shed light on this issue by comparing the genomic and transcriptomic profiles of different breast
Externí odkaz:
https://doaj.org/article/7eb9424dafc04cdfaba1f2ce0b7d5375
Autor:
Matthew G. Annis, Veronique Ouellet, Jonathan P. Rennhack, Sylvain L’Esperance, Claudine Rancourt, Anne-Marie Mes-Masson, Eran R. Andrechek, Peter M. Siegel
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-15 (2018)
Abstract Background The Fos-related antigen 1 (FRA-1) transcription factor promotes tumor cell growth, invasion and metastasis. Phosphorylation of FRA-1 increases protein stability and function. We identify a novel signaling axis that leads to increa
Externí odkaz:
https://doaj.org/article/9e9d826ca44a4555b9d14275fadf397d
Autor:
Tung Bui, Jonathan Rennhack, Stephanie Mok, Chen Ling, Marco Perez, Joshua Roccamo, Eran R. Andrechek, Christopher Moraes, William J. Muller
Publikováno v:
Cell Reports, Vol 29, Iss 3, Pp 589-602.e6 (2019)
Summary: Integrin receptors coordinate cell adhesion to the extracellular matrix (ECM) to facilitate many cellular processes during malignant transformation. Despite their pro-tumorigenic roles, therapies targeting integrins remain limited. Here, we
Externí odkaz:
https://doaj.org/article/7750798c61bc42919ba1edb539a0a944
Autor:
Alison Hirukawa, Salendra Singh, Jarey Wang, Jonathan P. Rennhack, Matthew Swiatnicki, Virginie Sanguin-Gendreau, Dongmei Zuo, Kamilia Daldoul, Cynthia Lavoie, Morag Park, Eran R. Andrechek, Thomas F. Westbrook, Lyndsay N. Harris, Vinay Varadan, Harvey W. Smith, William J. Muller
Publikováno v:
Cell Reports, Vol 29, Iss 2, Pp 249-257.e8 (2019)
Summary: Monoclonal antibodies (mAbs) targeting the oncogenic receptor tyrosine kinase ERBB2/HER2, such as Trastuzumab, are the standard of care therapy for breast cancers driven by ERBB2 overexpression and activation. However, a substantial proporti
Externí odkaz:
https://doaj.org/article/d72321d9dd27483ea95dfcd6db827f5b