Host biomarkers and combinatorial scores for the detection of serious and invasive bacterial infection in pediatric patients with fever without source.

Autor: Laurence Lacroix, Sebastien Papis, Chiara Mardegan, Fanny Luterbacher, Arnaud L'Huillier, Cyril Sahyoun, Kristina Keitel, Niv Mastboim, Liat Etshtein, Liran Shani, Einav Simon, Eran Barash, Roy Navon, Tanya M Gottlieb, Kfir Oved, Eran Eden, Christophe Combescure, Annick Galetto-Lacour, Alain Gervaix

Publikováno v: PLoS ONE, Vol 18, Iss 11, p e0294032 (2023)

BackgroundImproved tools are required to detect bacterial infection in children with fever without source (FWS), especially when younger than 3 years old. The aim of the present study was to investigate the diagnostic accuracy of a host signature com

Externí odkaz: https://doaj.org/article/59c9bf7424224d998e1fd13cf7bdf7aa

Observational cohort study of IP-10's potential as a biomarker to aid in inflammation regulation within a clinical decision support protocol for patients with severe COVID-19.

Autor: Shaul Lev, Tamar Gottesman, Gal Sahaf Levin, Doron Lederfein, Evgeny Berkov, Dror Diker, Aliza Zaidman, Amir Nutman, Tahel Ilan Ber, Alon Angel, Lior Kellerman, Eran Barash, Roy Navon, Olga Boico, Yael Israeli, Michal Rosenberg, Amir Gelman, Roy Kalfon, Einav Simon, Noa Avni, Mary Hainrichson, Oren Zarchin, Tanya M Gottlieb, Kfir Oved, Eran Eden, Boaz Tadmor

Publikováno v: PLoS ONE, Vol 16, Iss 1, p e0245296 (2021)

BackgroundTreatment of severely ill COVID-19 patients requires simultaneous management of oxygenation and inflammation without compromising viral clearance. While multiple tools are available to aid oxygenation, data supporting immune biomarkers for

Externí odkaz: https://doaj.org/article/c69bff099e774129b7d197cb27d15649

Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones

Autor: Bastiaan P. Krom, Nicholas T. Jacob, Kim D. Janda, Josep Rayo, Gunnar F. Kaufmann, Benjamin F. Cravatt, Herman S. Overkleeft, Alexander Aranovich, Michael M. Meijler, Erik A.C. Wiemer, Bogdan I. Florea, Valerie A. Kickhoefer, Manikandan Thangaraj, Rambabu Dandela, Tsaffrir Zor, John C. Mathison, Richard J. Ulevitch, Rachel Gregor, Orna Ernst, Sergey Malitsky, Luba Dubinsky, Vladimir V. Kravchenko, Eran Barash, Leonard H. Rome, Alex Yashkin

Publikováno v: Rayo, J, Gregor, R, Jacob, N T, Dandela, R, Dubinsky, L, Yashkin, A, Aranovich, A, Thangaraj, M, Ernst, O, Barash, E, Malitsky, S, Florea, B I, Krom, B P, Wiemer, E A C, Kickhoefer, V A, Rome, L H, Mathison, J C, Kaufmann, G F, Overkleeft, H S, Cravatt, B F, Zor, T, Janda, K D, Ulevitch, R J, Kravchenko, V V & Meijler, M M 2021, ' Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 12, e2012529118 . https://doi.org/10.1073/pnas.2012529118
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 12
Proceedings of the National Academy of Sciences of the United States of America, 118(12):e2012529118. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 118(12):e2012529118. National Acad Sciences
Proceedings of the National Academy of Sciences of the United States of America, 118(12), e2012529118

© 2021 National Academy of Sciences. All rights reserved.The major vault protein (MVP) mediates diverse cellular responses, including cancer cell resistance to chemotherapy and protection against inflammatory responses to Pseudomonas aeruginosa. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de316d4ca8b30affe8732f94f6cea422
https://doi.org/10.1073/pnas.2012529118

Observational cohort study of IP-10's potential as a biomarker to aid in inflammation regulation within a clinical decision support protocol for patients with severe COVID-19

Autor: Alon Angel, Aliza Zaidman, Yael Israeli, Noa Avni, Einav Simon, Mary Hainrichson, Roy Kalfon, Kfir Oved, Oren Zarchin, Doron Lederfein, Amir Nutman, Lior Kellerman, Tamar Gottesman, Shaul Lev, Eran Barash, Olga Boico, Gal Levin, Boaz Tadmor, Roy Navon, Evgeny Berkov, Tanya M. Gottlieb, Amir Gelman, Dror Diker, Eran Eden, Michal Rosenberg, Tahel Ilan Ber

Publikováno v: PLoS ONE
PLOS ONE
PLoS ONE, Vol 16, Iss 1, p e0245296 (2021)

Background Treatment of severely ill COVID-19 patients requires simultaneous management of oxygenation and inflammation without compromising viral clearance. While multiple tools are available to aid oxygenation, data supporting immune biomarkers for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca0acc46ab637a2946c73685a9acff3
https://pubmed.ncbi.nlm.nih.gov/33434221

BacPaCS-Bacterial Pathogenicity Classification via Sparse-SVM

Autor: Neta Sal-Man, Eran Barash, Michal Ziv-Ukelson, Sivan Sabato

Publikováno v: Bioinformatics (Oxford, England). 35(12)

Motivation Bacterial infections are a major cause of illness worldwide. However, most bacterial strains pose no threat to human health and may even be beneficial. Thus, developing powerful diagnostic bioinformatic tools that differentiate pathogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a7f674afd22f1a71e8cc126d464166
https://pubmed.ncbi.nlm.nih.gov/30407484