Zobrazeno 1 - 10
of 31 124
pro vyhledávání: '"Er-stress"'
Autor:
Paulina Czechowicz, Magdalena Gebert, Sylwia Bartoszewska, Leszek Kalinowski, James F. Collawn, Rafal Bartoszewski
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Regulation of endoplasmic reticulum (ER) homeostasis plays a critical role in maintaining cell survival. When ER stress occurs, a network of three pathways called the unfolded protein response (UPR) is activated to reestablish homeostasis. W
Externí odkaz:
https://doaj.org/article/0296c25c0d0c45bfb02887e1ee6f7a49
Publikováno v:
Animal Cells and Systems, Vol 28, Iss 1, Pp 481-494 (2024)
Quantum dots have diverse biomedical applications, from constructing biological infrastructures like medical imaging to advancing pharmaceutical research. However, concerns about human health arise due to the toxic potential of quantum dots based on
Externí odkaz:
https://doaj.org/article/85e6bcf702b940b5bd55b0d50418dc25
Autor:
Guozhi Yan, Rongrong Song, Jieyu Zhang, Zhihao Li, Zhantao Lu, Zijian Liu, Xiaokang Zeng, Jie Yao
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-11 (2024)
Abstract Rheumatoid arthritis (RA) is a common autoimmune disease that can lead to irreversible joint damage when it occurs, but its pathogenesis has not yet been elucidated. In this study, we explored the roles of macrophage migration inhibitory fac
Externí odkaz:
https://doaj.org/article/7d46b175209247d98090f09e7c2189ff
Autor:
Xiao-Chuan Xue, Yang-Yun Zhou, Ling-Yan Xu, Lan-Yi Wei, Yu-Jie Hu, Jiao Yang, Xiang-Qi Zhang, Meng-Yue Wang, Yong-Long Han, Jun-Jun Chen
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background In China, Tongguanteng injection (TGT) is widely used in the treatment or adjuvant treatment of various types of cancer. However, the effect and mechanism of TGT in osteosarcoma is not clear. Methods The 143B and MG-63 cells were
Externí odkaz:
https://doaj.org/article/3bc83a516cb5466b901590e5a5c38d9e
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-15 (2024)
Abstract Endoplasmic reticulum (ER) stress has been shown to play a pivotal role in the pathogenesis of asthma. DEPTOR (DEP Domain Containing MTOR Interacting Protein) is an endogenous mTOR inhibitor that participates in various physiological process
Externí odkaz:
https://doaj.org/article/d17f77d207634d43b54ccca1e049db68
Publikováno v:
Chinese Medicine, Vol 19, Iss 1, Pp 1-24 (2024)
Abstract Background Parkinson’s disease (PD) is a chronic neurodegenerative disorder that currently has no curable strategies. More and more evidence suggests that endoplasmic reticulum (ER) stress plays an essential role in PD pathogenesis. Peripl
Externí odkaz:
https://doaj.org/article/306845f12ddc4545a6e0bf50896b5a21
Autor:
Samia Anwar, Riffat Siddique, Shakeel Ahmad, Muhammad Zeshan Haider, Haider Ali, Adnan Sami, Rosa Sanchez Lucas, Muhammad Shafiq, Bader Un Nisa, Bilal Javed, Jannat Akram, Javaria Tabassum, Muhammad Arshad Javed
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract In plants, the BAX inhibitor-1 (BI-1) gene plays a crucial part in controlling cell death under stress conditions. This mechanism of Programmed Cell Death (PCD) is genetically regulated and is crucial for the elimination of unwanted or damag
Externí odkaz:
https://doaj.org/article/e454b4506a6441d9bfd8e85d28b6e314
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Bladder cancer stands as one of the most prevalent cancers worldwide. While our previous research confirmed the significant role of stearoyl-CoA desaturase (SCD) in bladder cancer, the underlying reasons for its abnormal overexpression remai
Externí odkaz:
https://doaj.org/article/9d23c1b0ae594d0591a3189e6e576037
Autor:
Kento Takeuchi, Kanji Yamaguchi, Yusuke Takahashi, Kota Yano, Shinya Okishio, Hiroshi Ishiba, Nozomi Tochiki, Seita Kataoka, Hideki Fujii, Naoto Iwai, Yuya Seko, Atsushi Umemura, Michihisa Moriguchi, Takeshi Okanoue, Yoshito Itoh
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract GDF15 and FGF21, stress-responsive cytokines primarily secreted from the liver, are promising therapeutic targets for metabolic dysfunction-associated steatotic liver disease (MASLD). However, the interaction between GDF15 and FGF21 remains
Externí odkaz:
https://doaj.org/article/df294e94fab24a5399ce4312726c6372
Autor:
Yiran Zhang, Xiusheng Chen, Laiqiang Chen, Mingting Shao, Wenzhen Zhu, Tingting Xing, Tingting Guo, Qingqing Jia, Huiming Yang, Peng Yin, Xiao-Xin Yan, Jiandong Yu, Shihua Li, Xiao-Jiang Li, Su Yang
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-22 (2024)
Abstract Background The activation of endoplasmic reticulum (ER) stress is an early pathological hallmark of Alzheimer’s disease (AD) brain, but how ER stress contributes to the onset and development of AD remains poorly characterized. Mesencephali
Externí odkaz:
https://doaj.org/article/20c6378e6c59460e8cba23c7081061d4