Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Er-Tuan Chuang"'
Autor:
Er-Tuan Chuang, Ching Hua Chiang, Hsin-Lung Chen, Yi Hsuan Chiu, Hsing-Wen Sung, Kun-Ju Lin, Jyuhn Huarng Juang, Po Yen Lin, Fwu Long Mi
Publikováno v:
Journal of Controlled Release. 259:168-175
Sodium dodecyl sulfate (SDS) is generally regarded as a potent permeability enhancer in oral formulations; however, one concern related to the use of any permeation enhancer is its possible absorption of unwanted toxins during the period of epithelia
Autor:
Zi-Xian Liao, Hao Ji Wei, Er-Tuan Chuang, Po-Yuan Cheng, Kun-Ju Lin, Hsing-Wen Sung, Yi Cheng Ho, Ko Jie Chen, Chia Chen Lin
Publikováno v:
Journal of Controlled Release. 208:42-51
Recent research in chemotherapy has prioritized overcoming the multidrug resistance (MDR) of cancer cells. In this work, liposomes that contain doxorubicin (DOX) and ammonium bicarbonate (ABC, a bubble-generating agent) are prepared and functionalize
Autor:
Younan Xia, Er-Tuan Chuang, Zi-Xian Liao, Hsing-Wen Sung, Yi Cheng Ho, Wei Lun Chiang, Min Suk Shim, Barnali Maiti, Hsiao Lan Pu
Publikováno v:
ACS Nano. 8:1213-1221
Oxidative stress and reduced pH are involved in many inflammatory diseases. This study describes a nanoparticle-based system that is responsive to both oxidative stress and reduced pH in an inflammatory environment to effectively release its encapsul
Autor:
Fang-Yi Su, Er-Tuan Chuang, Hsing-Wen Sung, Jyuhn Huarng Juang, Fwu Long Mi, Kun-Ju Lin, Tzu Chen Yen, Giang Thi Ha Nguyen, Chiung-Tong Chen
Publikováno v:
Biomaterials. 34:7994-8001
Current insulin therapy via subcutaneous administration can lead to occasional hypoglycemia and peripheral hyperinsulinemia, due to its nonphysiological route. This study evaluates the feasibility of using bovine insulin and exendin-4 in a form of co
Autor:
Deh Wei Tang, Wen Shin Wu, Hao Ying Hsieh, Fwu Long Mi, Er-Tuan Chuang, Bo Xian Lin, Hsing-Wen Sung, Shu Huei Yu
Publikováno v:
Acta Biomaterialia. 9:7449-7459
Fucoidan has the ability to inhibit angiogenesis by human umbilical vein endothelial cells (HUVECs). However, a major clinical limitation is its poor oral availability because fucoidan is a hydrophilic macromolecule. In this study, an oversulfation r
Publikováno v:
Annals of Plastic Surgery. 69:663-667
A quantum dot (QD)-conjugated collagen-hyaluronic acid (HA) porous scaffold was combined with our previously reported animal model of mice inferior epigastric flaps and QD infusion to study scaffold angiogenesis. A CdSe/ZnS QD-labeled collagen/HA sca
Autor:
Barnali Maiti, Fang-Yi Su, Kiran Sonaje, Hsing-Wen Sung, Tzu Chen Yen, Nilendu Panda, Yi Cheng Ho, Shiaw-Pyng Wey, Er-Tuan Chuang, Kun-Ju Lin
Publikováno v:
Biomaterials. 33:2801-2811
Complexing agents such as diethylene triamine pentaacetic acid (DTPA) are known to disrupt intestinal tight junctions and inhibit intestinal proteases by chelating divalent metal ions. This study attempts to incorporate these benefits of DTPA in func
Publikováno v:
Accounts of Chemical Research. 45:619-629
Despite advances in drug-delivery technologies, successful oral administration of protein drugs remains an elusive challenge. When protein drugs are administered orally, they can rapidly denature or degrade before they reach their targets. Such drugs
Autor:
Er-Tuan Chuang, Yi Cheng Ho, Kun-Ju Lin, Chia Chen Lin, Hsing-Wen Sung, Ko Jie Chen, Dehui Wan, Po Yen Lin
Publikováno v:
Biomaterials. 93
The nonspecific distribution of therapeutic agents and nontargeted heating commonly produce undesirable side effects during cancer treatment since the optimal timing of triggering the carrier systems is unknown. This work proposes a multifunctional l
Autor:
Jyuhn Huarng Juang, Chia Wei Hsu, Ho Ngoc Nguyen, Hsing-Wen Sung, Er-Tuan Chuang, Shiaw-Pyng Wey, Kiran Sonaje, Tzu Chen Yen, Yi Cheng Ho, Kun-Ju Lin
Publikováno v:
Biomaterials. 32:2673-2682
Exendin-4 is a potent insulinotropic agent in diabetes patients; however, its therapeutic utility is limited due to the frequent injections required. In this study, an orally available exendin-4 formulation, using an enteric-coated capsule containing