Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Er-Jia Wang"'
Autor:
Barecki-Roach, M., Er-Jia Wang
Publikováno v:
Xenobiotica. Feb2003, Vol. 33 Issue 2, p131. 10p.
Autor:
Thomas Klapmuts, Jun Chen, Er-Jia Wang, Mary Humphries, Annette S. Uss, Cindy Tran, Li Xiao, Yi-Zhong Gu, K.-C. Cheng, Pramila Kumari, Jairam Palamanda, Xinjie Lin
Publikováno v:
Drug Metabolism Letters. 3:61-66
The induction of dog CYP3A12 and CYP3A26 mRNA levels was evaluated in liver slices after treatment with 22 xenobiotics. Eleven of the 22 xenobiotics increased 3A12 mRNA by more than four-fold, while nine did the same for 3A26 mRNA. A four-fold increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c4fdca267f9f8f5fa8073fd521f266
https://doi.org/10.2174/187231209787176399
https://doi.org/10.2174/187231209787176399
Publikováno v:
Toxicological Sciences. 99:162-173
Phospholipidosis (PLD) is characterized by the excessive intracellular accumulation of phospholipids. It is well established that a large number of cationic amphiphilic drugs have the potential to induce PLD. In the present study, we describe two fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e619f4d37d9d863cf06205e5f379f8d
https://doi.org/10.1093/toxsci/kfm157
https://doi.org/10.1093/toxsci/kfm157
Publikováno v:
Journal of Pharmacy and Pharmacology. 55:1251-1257
The ATP-binding cassette transporter P-glycoprotein (P-gp) exerts a critical role in the systemic disposition of, and exposure to, lipophilic and amphipathic drugs, carcinogens, toxins and other xenobiotics. The ability of P-gp to transfer a wide var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e96711c4eb27e1df8a5beadabc8baed
https://doi.org/10.1211/0022357021666
https://doi.org/10.1211/0022357021666
Publikováno v:
Pharmaceutical Research. 20:537-544
Purpose. Although sister-P-glycoprotein (SPGP, BSEP) is closely related to P-glycoprotein, it is much more selective in distribution and substrate recognition. Moreover, because inhibition or lack of BSEP function has severe consequences including ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b610269d01539764491a861a701b5b6c
https://doi.org/10.1023/a:1023278211849
https://doi.org/10.1023/a:1023278211849
Autor:
Karen Lew, Er-jia Wang, William W. Johnson, Christopher N. Casciano, Robert P. Clement, Mary E. Barecki
Publikováno v:
Chemical Research in Toxicology. 14:1596-1603
The bulk of characterized xenobiotic defense and disposition is conferred by the abundant enzymes cytochrome P450 3A4 and P-glycoprotein. Although expressed in many tissues, these enzymes are most abundant in the liver and intestine and seem to share
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad73b203cd53179e1ae9d8b7e171a48
https://doi.org/10.1021/tx010125x
https://doi.org/10.1021/tx010125x
Publikováno v:
Biochemical and Biophysical Research Communications. 289:580-585
With P-glycoprotein (P-gp) continuing to have prominence among the ABC transporters for its ability to remove various xenobiotics from many cell types, accurate and robust methods for estimating the exposure of drug, carcinogen, toxicant, pesticide,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453ff180da1c5bc7cde154067bebe98f
https://doi.org/10.1006/bbrc.2001.6000
https://doi.org/10.1006/bbrc.2001.6000
Publikováno v:
Pharmaceutical Research. 18:432-438
Purpose. The grapefruit juice component bergamottin is known to inactivate cytochrome P450 3A4, with grapefruit juice consumption causing increased absorption and enhanced oral bioavailability of many cytochrome P450 3A4 substrates. Many of these sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f251aa10516aa456ed3029d1f39d7ebc
https://doi.org/10.1023/a:1011089924099
https://doi.org/10.1023/a:1011089924099
Publikováno v:
Pharmaceutical Research. 18:800-806
Purpose. HMG-CoA reductase inhibitors (statins) are commonly prescribed for lipid lowering to treat hypercholesterolemia. Although they are well tolerated, their pharmacokinetic interactions with other drugs can lead to some adverse clinical conseque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb8fd7323f8055474b4a10008354ea65
https://doi.org/10.1023/a:1011036428972
https://doi.org/10.1023/a:1011036428972
Publikováno v:
Archives of Biochemistry and Biophysics. 383:91-98
P-Glycoprotein (Pgp) is an important transport enzyme composed of two homologous domains and transports a wide range of structurally diverse xenobiotics from the cell. Recent studies have indicated that allosteric interactions occur between the nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac3b297631cfb5438bb32a3a2270b3a
https://doi.org/10.1006/abbi.2000.2004
https://doi.org/10.1006/abbi.2000.2004