Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Er Yen Yen"'
Autor:
Ziheng Chen, I-Lin Ho, Melinda Soeung, Er-Yen Yen, Jintan Liu, Liang Yan, Johnathon L. Rose, Sanjana Srinivasan, Shan Jiang, Q. Edward Chang, Ningping Feng, Jason P. Gay, Qi Wang, Jing Wang, Philip L. Lorenzi, Lucas J. Veillon, Bo Wei, John N. Weinstein, Angela K. Deem, Sisi Gao, Giannicola Genovese, Andrea Viale, Wantong Yao, Costas A. Lyssiotis, Joseph R. Marszalek, Giulio F. Draetta, Haoqiang Ying
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mitochondria are hubs where bioenergetics, redox homeostasis, and anabolic metabolism pathways integrate through a tightly coordinated flux of metabolites. The contributions of mitochondrial metabolism to tumor growth and therapy resistance
Externí odkaz:
https://doaj.org/article/ef0f3fa470bc4ac8bab02e6b16959230
Autor:
Sahil Seth, Chieh-Yuan Li, I-Lin Ho, Denise Corti, Sara Loponte, Luigi Sapio, Edoardo Del Poggetto, Er-Yen Yen, Frederick Scott Robinson, Michael Peoples, Tatiana Karpinets, Angela Kay Deem, Tapsi Kumar, Xingzhi Song, Shan Jiang, Ya’an Kang, Jason Fleming, Michael Kim, Jianhua Zhang, Anirban Maitra, Timothy Paul Heffernan, Virginia Giuliani, Giannicola Genovese, Andrew Futreal, Giulio Francesco Draetta, Alessandro Carugo, Andrea Viale
Publikováno v:
Cell Reports, Vol 26, Iss 6, Pp 1518-1532.e9 (2019)
Summary: Adaptive drug-resistance mechanisms allow human tumors to evade treatment through selection and expansion of treatment-resistant clones. Here, studying clonal evolution of tumor cells derived from human pancreatic tumors, we demonstrate that
Externí odkaz:
https://doaj.org/article/30566401e39148a182c3531e4ef7960d
Autor:
Ronald A. DePinho, Y. Alan Wang, Anirban Maitra, Nagireddy Putluri, Bidyut Ghosh, Denise J. Spring, Xiaoying Shang, Haoqiang Ying, Qing Chang, Federica Carbone, Tingxin Zhang, Pingna Deng, Deepavali Chakravarti, Jielin Liu, Pat Gulhati, Giannicola Genovese, Er-Yen Yen, Vincent Bernard, Parker Denz, Frederick Cavallaro, Wen-Ting Liao, Huamin Wang, Anders Strom, Surendra Chaurasiya, Jianhua Zhang, Jun Li, Prasenjit Dey
A hallmark of pancreatic ductal adenocarcinoma (PDAC) is an exuberant stroma comprised of diverse cell types that enable or suppress tumor progression. Here, we explored the role of oncogenic KRAS in protumorigenic signaling interactions between canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2acee54951bb1043fe719d0c41208304
https://doi.org/10.1158/2159-8290.c.6547793.v1
https://doi.org/10.1158/2159-8290.c.6547793.v1
Autor:
Ronald A. DePinho, Y. Alan Wang, Anirban Maitra, Nagireddy Putluri, Bidyut Ghosh, Denise J. Spring, Xiaoying Shang, Haoqiang Ying, Qing Chang, Federica Carbone, Tingxin Zhang, Pingna Deng, Deepavali Chakravarti, Jielin Liu, Pat Gulhati, Giannicola Genovese, Er-Yen Yen, Vincent Bernard, Parker Denz, Frederick Cavallaro, Wen-Ting Liao, Huamin Wang, Anders Strom, Surendra Chaurasiya, Jianhua Zhang, Jun Li, Prasenjit Dey
Supplementary Figures 1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0383a7f1e506d7a2366f56fd7030c34
https://doi.org/10.1158/2159-8290.22535237
https://doi.org/10.1158/2159-8290.22535237
Autor:
Elizabeth A. Mittendorf, Stacy L. Moulder, Ryan Sun, Ignacio I. Wistuba, Andrew Futreal, Gabriel N. Hortobagyi, Jennifer A. Wargo, Jennifer K. Litton, Senthil Damodaran, Gaiane M. Rauch, Jennifer L. Guerriero, Sahil Seth, Elizabeth Ravenberg, Jason B. White, William Fraser Symmans, Edwin Roger Parra Cuentas, Baohua Sun, Xiangjie Sun, Kasthuri Kannan, Naoto T. Ueno, Bora Lim, Qing-Qing Ding, Anne V. Philips, Fei Yang, Lei Huo, Haven Garber, Gheath Alatrash, Roland L. Bassett, Jeffrey T. Chang, Er-Yen Yen, Clinton Yam
Supplementary Tables S1-5 and Supplementary Fig. S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2798869b9d39f49bf3444bb77fdfa31d
https://doi.org/10.1158/1078-0432.22481015
https://doi.org/10.1158/1078-0432.22481015
Autor:
Elizabeth A. Mittendorf, Stacy L. Moulder, Ryan Sun, Ignacio I. Wistuba, Andrew Futreal, Gabriel N. Hortobagyi, Jennifer A. Wargo, Jennifer K. Litton, Senthil Damodaran, Gaiane M. Rauch, Jennifer L. Guerriero, Sahil Seth, Elizabeth Ravenberg, Jason B. White, William Fraser Symmans, Edwin Roger Parra Cuentas, Baohua Sun, Xiangjie Sun, Kasthuri Kannan, Naoto T. Ueno, Bora Lim, Qing-Qing Ding, Anne V. Philips, Fei Yang, Lei Huo, Haven Garber, Gheath Alatrash, Roland L. Bassett, Jeffrey T. Chang, Er-Yen Yen, Clinton Yam
Purpose:Increasing tumor-infiltrating lymphocytes (TIL) is associated with higher rates of pathologic complete response (pCR) to neoadjuvant therapy (NAT) in patients with triple-negative breast cancer (TNBC). However, the presence of TILs does not c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cabd8a09d448357a2b51536e36f8348
https://doi.org/10.1158/1078-0432.c.6530597.v1
https://doi.org/10.1158/1078-0432.c.6530597.v1
Autor:
Anne V. Philips, Jason B White, Jennifer A. Wargo, Sahil Seth, Xiangjie Sun, Senthil Damodaran, Andrew Futreal, Gabriel N. Hortobagyi, Er-Yen Yen, Clinton Yam, Baohua Sun, Gheath Alatrash, Stacy L. Moulder, Qingqing Ding, Edwin Roger Parra Cuentas, Ignacio I. Wistuba, Fei Yang, Elizabeth A. Mittendorf, Jeffrey T. Chang, Elizabeth Ravenberg, Haven R. Garber, Jennifer L. Guerriero, Bora Lim, Jennifer K. Litton, Ryan Sun, Lei Huo, Kasthuri Kannan, Naoto T. Ueno, Roland L. Bassett, Gaiane M. Rauch, William Fraser Symmans
Publikováno v:
Clin Cancer Res
Purpose: Increasing tumor-infiltrating lymphocytes (TIL) is associated with higher rates of pathologic complete response (pCR) to neoadjuvant therapy (NAT) in patients with triple-negative breast cancer (TNBC). However, the presence of TILs does not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d514d3ca018b4a1893424f007cf22d
https://doi.org/10.1158/1078-0432.ccr-21-0144
https://doi.org/10.1158/1078-0432.ccr-21-0144
Autor:
Ziheng Chen, I-Lin Ho, Melinda Soeung, Er-Yen Yen, Johnathon Rose, Sanjana Srinivasan, Angela Deem, Sisi Gao, Haoqiang Ying, Giulio Draetta
Publikováno v:
Cancer Research. 83:1683-1683
Mitochondria are hubs where bioenergetics, redox homeostasis, and anabolic metabolism pathways integrate through a tightly coordinated flux of metabolites. The essential contributions of mitochondrial metabolism to fuel tumor growth and resistance to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::015c5c1a87ea0e2f90a6670b35eca8bb
https://doi.org/10.1158/1538-7445.am2023-1683
https://doi.org/10.1158/1538-7445.am2023-1683
Autor:
Er-Yen Yen, I-Lin Ho, Chieh-Yuan Li, Charles Dyke, Shan Jiang, Francesca Citron, Sergio Attanasio, Rutvi Shah, Ko-Chien Chen, Giulio Draetta, Andrea Viale
Publikováno v:
Cancer Research. 83:5868-5868
The lack of suitable experimental approaches to investigate and model functional heterogeneity in vivo has had a profound negative impact on our understanding of how heterogeneity affects the response to immunotherapy. To bridge this technological ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67df3a01e5ede7c58e83ba02c5b0aaec
https://doi.org/10.1158/1538-7445.am2023-5868
https://doi.org/10.1158/1538-7445.am2023-5868
Autor:
Francesca Citron, Luigi Perelli, Yanshuo Chu, Sanjana Srinivasan, I-Lin Ho, Er-Yen Yen, Rutvi Shah, Sergio Attanasio, Luis Castillo Montanez, Mauro Di Pilato, Shan Jiang, Wantong Yao, Sisi Gao, Angela Deem, Giannicola Genovese, Linghua Wang, Virginia Giuliani, Andrea Viale, Giulio F. Draetta
Publikováno v:
Cancer Research. 83:303-303
Introduction: DNA replication is a tightly regulated, multi-step process involving licensing and replication factors that faithfully orchestrate a single duplication of the entire genome exclusively during S phase of the cell cycle. Although the mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98e89207db6340b1a2c18bf00f123b8b
https://doi.org/10.1158/1538-7445.am2023-303
https://doi.org/10.1158/1538-7445.am2023-303