Tcf-1 protects anti-tumor TCR-engineered CD8 ⁺ T-cells from GzmB mediated self-destruction.

Autor: Zangari B; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Tsuji T; University of Chicago Medicine Comprehensive Cancer Center, 5841 S Maryland Ave, Chicago, IL, 60637, USA.; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, USA., Matsuzaki J; University of Chicago Medicine Comprehensive Cancer Center, 5841 S Maryland Ave, Chicago, IL, 60637, USA.; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, USA., Mohammadpour H; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Eppolito C; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Battaglia S; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; Department of Genetics and Genomics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Ito F; Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Chodon T; University of Chicago Medicine Comprehensive Cancer Center, 5841 S Maryland Ave, Chicago, IL, 60637, USA.; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, USA., Koya R; University of Chicago Medicine Comprehensive Cancer Center, 5841 S Maryland Ave, Chicago, IL, 60637, USA.; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, USA., Robert McGray AJ; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Odunsi K; University of Chicago Medicine Comprehensive Cancer Center, 5841 S Maryland Ave, Chicago, IL, 60637, USA. odunsia@bsd.uchicago.edu.; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, USA. odunsia@bsd.uchicago.edu.

Publikováno v: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2022 Dec; Vol. 71 (12), pp. 2881-2898. Date of Electronic Publication: 2022 Apr 23.

CXCR6 by increasing retention of memory CD8 ⁺ T cells in the ovarian tumor microenvironment promotes immunosurveillance and control of ovarian cancer.

Autor: Muthuswamy R; Center For Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA., McGray AR; Center For Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA., Battaglia S; Center For Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA., He W; Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA., Miliotto A; Center For Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA., Eppolito C; Center For Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA., Matsuzaki J; Center For Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.; University of Chicago Medicine Comprehensive Cancer Center, University of Chicago, Chicago, Illinois, USA., Takemasa T; Center For Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.; University of Chicago Medicine Comprehensive Cancer Center, University of Chicago, Chicago, Illinois, USA., Koya R; Center For Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.; University of Chicago Medicine Comprehensive Cancer Center, University of Chicago, Chicago, Illinois, USA., Chodon T; Center For Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.; University of Chicago Medicine Comprehensive Cancer Center, University of Chicago, Chicago, Illinois, USA., Lichty BD; Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Shrikant P; Department of Microbiology and Immunology, University of Arizona, Tucson, Arizona, USA., Odunsi K; University of Chicago Medicine Comprehensive Cancer Center, University of Chicago, Chicago, Illinois, USA odunsia@bsd.uchicago.edu.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2021 Oct; Vol. 9 (10).

Tumor Microenvironment Drives the Cross-Talk Between Co-Stimulatory and Inhibitory Molecules in Tumor-Infiltrating Lymphocytes: Implications for Optimizing Immunotherapy Outcomes.

Autor: Franzese, Ornella¹ (AUTHOR) franzese@uniroma2.it

Publikováno v: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 23, p12848. 41p.

Research progress and challenges of the PD-1/PD-L1 axis in gliomas.

Autor: Jiacheng, Dong¹ (AUTHOR), Jiayue, Cui² (AUTHOR), Ying, Guo² (AUTHOR), Shaohua, Wang³ (AUTHOR), Wenhui, Liu² (AUTHOR), Xinyu, Hong¹ (AUTHOR) hongxy@jlu.edu.cn

Publikováno v: Cell & Bioscience. 9/27/2024, Vol. 14 Issue 1, p1-13. 13p.

Oncolytic Maraba virus armed with tumor antigen boosts vaccine priming and reveals diverse therapeutic response patterns when combined with checkpoint blockade in ovarian cancer.

Autor: McGray AJR; Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Elm and Carlton Sts, Buffalo, NY, 14263, USA., Huang RY; Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Elm and Carlton Sts, Buffalo, NY, 14263, USA., Battaglia S; Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Elm and Carlton Sts, Buffalo, NY, 14263, USA., Eppolito C; Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Elm and Carlton Sts, Buffalo, NY, 14263, USA., Miliotto A; Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Elm and Carlton Sts, Buffalo, NY, 14263, USA., Stephenson KB; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Turnstone Biologics, Ottawa, ON, Canada., Lugade AA; Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Elm and Carlton Sts, Buffalo, NY, 14263, USA., Webster G; Innate Immunotherapeutics, Auckland, NZ, New Zealand., Lichty BD; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Turnstone Biologics, Ottawa, ON, Canada., Seshadri M; Department of Dentistry and Maxillofacial Prosthetics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Kozbor D; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Odunsi K; Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Elm and Carlton Sts, Buffalo, NY, 14263, USA. kunle.odunsi@roswellpark.org.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2019 Jul 17; Vol. 7 (1), pp. 189. Date of Electronic Publication: 2019 Jul 17.