Zobrazeno 1 - 10 of 315 pro vyhledávání: '"Epoxide hydrolase activity"'
1
Configurational Assignment of a Flexible Benzo[g]isochromene Stereodiad from Rubia philippinensis and Inhibition of Soluble Epoxide Hydrolase Activity
Autor: Joonseok Oh, MinKyun Na, Daneel Ferreira, InWha Park, Chung Sub Kim, Young Ho Kim, Wesley Y. Yoshida, Khong Trong Quan, Phuong Thien Thuong
Publikováno v: Journal of Natural Products. 84:2594-2599
A new benzo[g]isochromene possessing a conformationally mobile moiety was identified from Rubia philippinensis. The 2D structure was established utilizing spectrometric and spectroscopic techniques with variable temperatures. The configurational inve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9445d8a24e16484f52c3c9748e7ff25
https://doi.org/10.1021/acs.jnatprod.1c00037
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2
Akademický článek
Isolation of Two New Compounds and Other Constituents from Leaves of Piper crocatum and Study of Their Soluble Epoxide Hydrolase Activities
Autor: Hong Xu Li, Seo Young Yang, Young Ho Kim, Wei Li
Publikováno v: Molecules, Vol 24, Iss 3, p 489 (2019)
Two new phenolic glucosides, pipercroside A and B (1 and 2), along with 10 known compounds were isolated from the leaves of Piper crocatum Ruiz & Pav. Their chemical structures were elucidated through extensive spectroscopic analyses, including 1D an
Externí odkaz: https://doaj.org/article/02d4207415b44c13a0d1b6c4128c301c
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3
Ibuprofen alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different metabolic pathways in murine livers
Autor: Bruce D. Hammock, Shuchita Tiwari, Jun Yang, Blythe Durbin-Johnson, Christophe Morisseau, Aldrin V. Gomes
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Scientific reports, vol 11, iss 1
Scientific Reports
Over the last decade oxylipins have become more recognized for their involvement in several diseases. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen are known to inhibit cyclooxygenase (COX) enzymes, but how NSAIDs affect oxylipins,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706c6945c2abb5306509f2e6bc52b707
https://doaj.org/article/2ef65391234346909ae9300681254922
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4
GSK2256294 Decreases sEH (Soluble Epoxide Hydrolase) Activity in Plasma, Muscle, and Adipose and Reduces F2-Isoprostanes but Does Not Alter Insulin Sensitivity in Humans
Autor: Robert Manning, John R. Koethe, Hui Nian, Chang Yu, Jorge L. Gamboa, Justina Ray, LaToya Hannah, Anthony DeMatteo, Mona Mashayekhi, Dawei Wei, James M. Luther, Dungeng Peng, Nancy J. Brown, Andrew S. Terker
Publikováno v: Hypertension
Epoxyeicosatrienoic acids (EETs) reduce blood pressure by acting in the vasculature and kidney, and interventions to increase circulating EETs improve insulin sensitivity and prevent diabetes in animal models. Inhibition of EET hydrolysis with a sEH
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4291bee92ebfac0bf5f1745e49d6639d
https://pubmed.ncbi.nlm.nih.gov/34455816
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5
Fatty Acyl Lipidomic Changes Converge Towards Increased Inflammation with Severity of COVID-19
Autor: Krishna Rao Maddipati, S. Kates, Thomas H. Thatcher, P.D. Jackson, Patricia J. Sime, Margaret A.T. Freeberg, Apostolos Perelas, J. R. Owen, Kenneth V. Honn
Publikováno v: TP3. TP003 COVID-19 INFECTIONS, MECHANISMS, AND CLINICAL IMPLICATIONS.
Background: COVID19 is a heterogeneous disease;while some patients experience mild or asymptomatic disease, others develop respiratory failure and death. Although there is increased understanding of clinical factors associated with severe disease, st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1e0fb98147269fe845bf9e93c169bd8
https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1285
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6
Mycobacterial Epoxide Hydrolase EphD Is Inhibited by Urea and Thiourea Derivatives
Autor: Jan Madacki, Mary Jackson, Jana Korduláková, Martin Kopál
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 2884, p 2884 (2021)
Volume 22
Issue 6
The genome of the human intracellular pathogen Mycobacterium tuberculosis encodes an unusually large number of epoxide hydrolases, which are thought to be involved in lipid metabolism and detoxification reactions needed to endure the hostile environm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc02d0665b664c3c9ef3fbf05061962
http://europepmc.org/articles/PMC7998700
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7
Isolation of a novel strain, Sphingorhabdus sp. YGSMI21 and characterization of its enantioselective epoxide hydrolase activity
Autor: Ho Young Suk, Jung-Hee Woo, Hae-Seon Kim, Nyun-Ho Park
Publikováno v: Journal of microbiology (Seoul, Korea). 59(7)
Sphingorhabdus sp. YGSMI21, a novel microbial strain with an enantioselective epoxide hydrolase activity, was isolated from tidal samples contaminated by accidental oil spills subjected to enriched culture with polycyclic aromatic hydrocarbon. This s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba33e4c22845430bb57df709968996c
https://pubmed.ncbi.nlm.nih.gov/34061338
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8
Isolation of Two New Compounds and Other Constituents from Leaves of Piper crocatum and Study of Their Soluble Epoxide Hydrolase Activities
Autor: Wei Li, Seo Young Yang, Hong Xu Li, Young Ho Kim
Publikováno v: Molecules, Vol 24, Iss 3, p 489 (2019)
Molecules
Two new phenolic glucosides, pipercroside A and B (1 and 2), along with 10 known compounds were isolated from the leaves of Piper crocatum Ruiz & Pav. Their chemical structures were elucidated through extensive spectroscopic analyses, including 1D an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd77b0a426bc5a88875ac1175d1586b
https://www.mdpi.com/1420-3049/24/3/489
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9
Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking
Autor: Qosay Al-Balas, Amanda C. Bryant-Friedrich, Buthina A. Al-Oudat, Suaad A. Audat, Nizar A. Al-Shar’i, Mel F. Bedi, Aref Zayed
Publikováno v: Molecules, Vol 25, Iss 2871, p 2871 (2020)
Molecules
Volume 25
Issue 12
Leukotriene B4 (LTB4) is a potent, proinflammatory lipid mediator implicated in the pathologies of an array of inflammatory diseases and cancer. The biosynthesis of LTB4 is regulated by the leukotriene A4 hydrolase (LTA4H). Compounds capable of limit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bde40f5bc89618488f2b8240b86b5c
https://www.mdpi.com/1420-3049/25/12/2871
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10
TOXICOKINETIC AND TOXICODYNAMIC SYMBIOTIC INTERACTIONS AMONG INTESTINAL Pseudomonas DEGRADING OF HYDROCARBONS WITH ITS WILD HOST FISH Chirostoma jordani
Autor: Ruth L. Madera-Sandoval, Minerva Nájera-Martínez, Graciela Castro-Escarpulli, María Lilia Domínguez-López, Ethel García-Latorre, María Esperanza Gallegos Rangel, Armando Vega-López
Publikováno v: Instituto Politécnico Nacional
IPN
Redalyc-IPN
Revista Internacional de Contaminación Ambiental (México) Num.4 Vol.34
The symbiotic relationship between native microbiota and their hosts probably is a key factor in animal survival. In this study, the relationships of Pseudomonas spp. strains with specific biomarkers of exposure to polycyclic aromatic hydrocarbons (P
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ad16062ad312f9515c8ad98bc4948f
https://doi.org/10.20937/rica.2018.34.04.15
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