Zobrazeno 1 - 10
of 1 465
pro vyhledávání: '"Epoxide hydrolase 2"'
Autor:
Jinlong He, Yin-Jiao Zhao, Xue-Lian Shi, Liu Yao, Yanhong Zhang, Xu Zhang, Bochuan Li, Hui Wang, Zhen Cui, Yi Zhu, Ding Ai
Publikováno v:
Hypertension (Dallas, Tex. : 1979)
Supplemental Digital Content is available in the text.
Endothelial cells play a critical role in maintaining homeostasis of vascular function, and endothelial activation is involved in the initial step of atherogenesis. Previously, we reported t
Endothelial cells play a critical role in maintaining homeostasis of vascular function, and endothelial activation is involved in the initial step of atherogenesis. Previously, we reported t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81db8f363fd137f970e1759f170329d2
https://doi.org/10.1161/hypertensionaha.121.17548
https://doi.org/10.1161/hypertensionaha.121.17548
Autor:
Jie Chen, Xinhong Zhu, Yang Liu, Hui Huang, Kun Zhang, Changming Xie, Jieping Huang, Wanbing He
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Vascular calcification is common in chronic kidney disease (CKD) and contributes to cardiovascular disease (CVD) without any effective therapies available up to date. The expression of soluble epoxide hydrolase (sEH) is different in patients with and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e288fa1a9fd3a725dc4f9eaa471490fb
https://doaj.org/article/51a1114befa94cd7b0972bf0bbf2a430
https://doaj.org/article/51a1114befa94cd7b0972bf0bbf2a430
Autor:
Yunfei Tan, Lijia Chang, Yuko Fujita, Yan Wei, Xiayun Wan, Tamaki Ishima, Siming Wang, Xingming Wang, Jiajing Shan, Jiancheng Zhang, Yaoyu Pu, Li Ma, Kenji Hashimoto, Bruce D. Hammock, Youge Qu
Publikováno v:
J Affect Disord
Background The brain–gut–microbiota axis plays a crucial role in the bidirectional interactions between the brain and the gut. Soluble epoxide hydrolase (coded by the Ephx2 gene) plays an important role in inflammation, which has been implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b3388cbeae91e90e2a1b9e5b8a2f1a
https://doi.org/10.1016/j.jad.2021.06.006
https://doi.org/10.1016/j.jad.2021.06.006
Autor:
Joonseok Oh, MinKyun Na, Daneel Ferreira, InWha Park, Chung Sub Kim, Young Ho Kim, Wesley Y. Yoshida, Khong Trong Quan, Phuong Thien Thuong
Publikováno v:
Journal of Natural Products. 84:2594-2599
A new benzo[g]isochromene possessing a conformationally mobile moiety was identified from Rubia philippinensis. The 2D structure was established utilizing spectrometric and spectroscopic techniques with variable temperatures. The configurational inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9445d8a24e16484f52c3c9748e7ff25
https://doi.org/10.1021/acs.jnatprod.1c00037
https://doi.org/10.1021/acs.jnatprod.1c00037
Publikováno v:
Medicinal Chemistry Research. 30:1738-1746
Epoxyeicosatrienoic acids (EETs) are produced by the effect of cytochrome P 450 (CYP) on arachidonic acid (AA), and have a beneficial performance to renal and cardiovascular systems. In recent decades, many new pharmacological agents have been develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15d3be0f5902bf6fd6b0da2c0b4bdf3f
https://doi.org/10.1007/s00044-021-02752-3
https://doi.org/10.1007/s00044-021-02752-3
Autor:
Liman Luo, Yueting Cai, Shuiqing Hu, Ling Tu, Menglu Fu, Wenhua Li, Ruolan Dong, Yuan-Yuan Li, Yan Yang, Xizhen Xu, Jinlan Luo
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 321:H353-H368
Arterial stiffness, a consequence of smoking, is an underlying risk factor of cardiovascular diseases. Epoxyeicosatrienoic acids (EETs), hydrolyzed by soluble epoxide hydrolase (sEH), have beneficial effects against vascular dysfunction. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1a126d7366195f699f31ce3106c483
https://doi.org/10.1152/ajpheart.00979.2020
https://doi.org/10.1152/ajpheart.00979.2020
Autor:
Charles C. Caldwell, Christian B. Bergmann, Holly S. Goetzman, Bruce D. Hammock, Dorothy M. Supp, Falk Gogolla, Debin Wan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific reports, vol 11, iss 1
Scientific Reports
Scientific reports, vol 11, iss 1
Oxylipins modulate the behavior of immune cells in inflammation. Soluble epoxide hydrolase (sEH) converts anti-inflammatory epoxyeicosatrienoic acid (EET) to dihydroxyeicosatrienoic acid (DHET). An sEH-inhibitor, TPPU, has been demonstrated to amelio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f998fded3f9997fa71344ea4947fae
https://doaj.org/article/6300e06abb654c439c3679971309bcfc
https://doaj.org/article/6300e06abb654c439c3679971309bcfc
Autor:
Xiaoqin Wu, Xiaohua Li
Publikováno v:
Archives of Medical Science. 17:1075-1086
IntroductionOxidative stress can cause intestinal disease. Soluble epoxide hydrolase (sEH, Ephx2) is related to cell apoptosis. The effect of Ephx2 on the H2O2-induced oxidative damage remains unclear. Thus, we aimed to explore the effect of Ephx2 on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22d225ea9465062404be5c8ca6306203
https://doi.org/10.5114/aoms.2019.87137
https://doi.org/10.5114/aoms.2019.87137
Autor:
Bruce D. Hammock, Christophe Morisseau, Tony Muchamuel, Janet L. Anderl, Henry Johnson, Dustin McMinn, Ying Fang, Christopher J. Kirk, Jinhai Wang
Publikováno v:
Drug Metabolism and Disposition. 49:810-821
KZR-616 is an irreversible tripeptide epoxyketone-based selective inhibitor of the human immunoproteasome. Inhibition of the immunoproteasome results in anti-inflammatory activity in vitro and, based on promising therapeutic activity in animal models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2d7bf887c79ec6526156696fadfdbe
https://doi.org/10.1124/dmd.120.000307
https://doi.org/10.1124/dmd.120.000307
Autor:
V. V. Burmistrov, D. A. Pitushkin, Gennady M. Butov, A. V. Eshtukov, Ya. P. Kuznetsov, E. V. Rasskazova, V. V. Vasipov
Publikováno v:
Russian Journal of Organic Chemistry. 57:1036-1046
A series of N,N′-disubstituted selenoureas containing an adamantane fragment have been synthesized in 23–75% yields. Procedures for the isolation and purification of aromatic isoselenocyanates have been improved. The chemical shift of the C=Se ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ba2bd0bc5a0939675c1b4dd15ea6420
https://doi.org/10.1134/s1070428021070022
https://doi.org/10.1134/s1070428021070022