Metabolomics reveals soluble epoxide hydrolase as a therapeutic target for high-sucrose diet-mediated gut barrier dysfunction.

Autor: Lin AZ; Department of Anesthesia of the Second Affiliated Hospital and CNTTI of College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, Chongqing 400016, China., Fu X; Department of Anesthesia of the Second Affiliated Hospital and CNTTI of College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, Chongqing 400016, China., Jiang Q; Department of Anesthesia of the Second Affiliated Hospital and CNTTI of College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, Chongqing 400016, China., Zhou X; Department of Anesthesia of the Second Affiliated Hospital and CNTTI of College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, Chongqing 400016, China., Hwang SH; Department of Entomology and Nematology, University of California, Davis, CA 95616.; Comprehensive Cancer Center, University of California, Davis, CA 95616., Yin HH; Department of Anesthesia of the Second Affiliated Hospital and CNTTI of College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, Chongqing 400016, China., Ni KD; Department of Anesthesia of the Second Affiliated Hospital and CNTTI of College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, Chongqing 400016, China., Pan QJ; Department of Anesthesia of the Second Affiliated Hospital and CNTTI of College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, Chongqing 400016, China., He X; Department of Anesthesia of the Second Affiliated Hospital and CNTTI of College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, Chongqing 400016, China., Zhang LT; Department of Anesthesia of the Second Affiliated Hospital and CNTTI of College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, Chongqing 400016, China., Meng YW; Department of Anesthesia of the Second Affiliated Hospital and CNTTI of College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, Chongqing 400016, China., Liu YN; Department of Anesthesia of the Second Affiliated Hospital and CNTTI of College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, Chongqing 400016, China., Hammock BD; Department of Entomology and Nematology, University of California, Davis, CA 95616.; Comprehensive Cancer Center, University of California, Davis, CA 95616., Liu JY; Department of Anesthesia of the Second Affiliated Hospital and CNTTI of College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, Chongqing 400016, China.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Nov 26; Vol. 121 (48), pp. e2409841121. Date of Electronic Publication: 2024 Nov 18.

Exploring the impact of sEH inhibition on intestinal cell differentiation and Colon Cancer: Insights from TPPU treatment.

Autor: Koubova K; Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic., Tauber Z; Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic., Cizkova K; Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic. Electronic address: katerina.cizkova@upol.cz.

Publikováno v: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2024 Nov; Vol. 492, pp. 117128. Date of Electronic Publication: 2024 Oct 15.

Improving Hydrolytic Activity and Enantioselectivity of Epoxide Hydrolase from Phanerochaete chrysosporium by Directed Evolution.

Autor: Shao H; College of Life Sciences, Sichuan Normal University, Chenglong Avenue, Chengdu 610101, China., Xu P; College of Life Sciences, Sichuan Normal University, Chenglong Avenue, Chengdu 610101, China.; Sichuan Institute of Atomic Energy, Yidu West Road, Chengdu 610101, China., Tao X; College of Life Sciences, Sichuan Normal University, Chenglong Avenue, Chengdu 610101, China., He X; College of Life Sciences, Sichuan Normal University, Chenglong Avenue, Chengdu 610101, China., Pu C; College of Life Sciences, Sichuan Normal University, Chenglong Avenue, Chengdu 610101, China., Liang S; College of Life Sciences, Sichuan Normal University, Chenglong Avenue, Chengdu 610101, China., Shi Y; College of Life Sciences, Sichuan Normal University, Chenglong Avenue, Chengdu 610101, China., Wang X; College of Life Sciences, Sichuan Normal University, Chenglong Avenue, Chengdu 610101, China., Feng H; College of Life Sciences, Sichuan University, Wangjiang Road, Chengdu 610199, China., Yong B; College of Life Sciences, Sichuan Normal University, Chenglong Avenue, Chengdu 610101, China.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2024 Oct 14; Vol. 29 (20). Date of Electronic Publication: 2024 Oct 14.

Engineering an Epoxide Hydrolase for Chemoenzymatic Asymmetric Synthesis of Chiral Triazole Fungicide ( S )- and ( R )-Flutriafol.

Autor: Hu D; School of Pharmacy & School of Biological and Food Engineering, Changzhou University, Changzhou 213164, China., Lu ZY; School of Pharmacy & School of Biological and Food Engineering, Changzhou University, Changzhou 213164, China., Liao X; School of Pharmacy & School of Biological and Food Engineering, Changzhou University, Changzhou 213164, China., Jia XW; School of Pharmacy & School of Biological and Food Engineering, Changzhou University, Changzhou 213164, China., Song WH; School of Pharmacy & School of Biological and Food Engineering, Changzhou University, Changzhou 213164, China., Hu YY; School of Pharmacy & School of Biological and Food Engineering, Changzhou University, Changzhou 213164, China., He YC; School of Pharmacy & School of Biological and Food Engineering, Changzhou University, Changzhou 213164, China.

Publikováno v: Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Oct 02; Vol. 72 (39), pp. 21741-21751. Date of Electronic Publication: 2024 Sep 19.

Inhibition of soluble epoxide hydrolase by natural isothiocyanates.

Autor: Elbarbry F; School of Pharmacy, Pacific University, 222 SE 8th Ave, Ste. 451, Hillsboro, OR, 97123, USA. Electronic address: Fawzy.elbarbry@pacificu.edu., Espiritu MJ; School of Pharmacy, Pacific University, 222 SE 8th Ave, Ste. 451, Hillsboro, OR, 97123, USA., Soo K; School of Pharmacy, Pacific University, 222 SE 8th Ave, Ste. 451, Hillsboro, OR, 97123, USA., Yee B; School of Pharmacy, Pacific University, 222 SE 8th Ave, Ste. 451, Hillsboro, OR, 97123, USA., Taylor J; School of Pharmacy, Pacific University, 222 SE 8th Ave, Ste. 451, Hillsboro, OR, 97123, USA.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Sep 17; Vol. 725, pp. 150261. Date of Electronic Publication: 2024 Jun 12.