Engineering a vector-based pan-Leishmania vaccine for humans: proof of principle

Autor: Fabiano Oliveira, Tiago D. Serafim, James Oristian, Claudio Meneses, Pedro Cecílio, Jesus G. Valenzuela, Anabela Cordeiro da Silva

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Scientific Reports

Leishmaniasis is a spectrum of diseases transmitted by sand fly vectors that deposit Leishmania spp. parasites in the host skin during blood feeding. Currently, available treatment options are limited, associated with high toxicity and emerging resis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56c69e9dfc23530c8ef6c34127b845d
https://hdl.handle.net/10216/143504

Seropositivity and Antibody Profiling of Patients Are Dramatically Impacted by the Features of Peptides Used as Immunosorbents: A Lesson from Anti–Citrullinated Protein/Peptide Antibody

Autor: Cornillet, Martin, Babos, Fruzsina, Magyar, Anna, Sebbag, Mireille, Verrouil, Evelyne, Hudecz, Ferenc, Serre, Guy, Nogueira, Leonor

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2018, 201 (11), pp.3211-3217. ⟨10.4049/jimmunol.1800330⟩

International audience; Quantification of Abs toward a single epitope is critical to understanding immunobiological processes. In autoimmunity, the prognostic value of the serological profiles of patients draws much attention, but the detection of Ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c146dee0baed7c7fc6e8495d834741aa
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03156386

Caractérisation d'anticorps neutralisants réagissant avec le segment des acides aminés 213-224 de la galectine-9 humaine

Autor: Claire Lhuillier, Clément Barjon, Valentin Baloche, Toshiro Niki, Aurore Gelin, Rami Mustapha, Laetitia Claër, Sylviane Hoos, Yoichi Chiba, Masaki Ueno, Mitsuomi Hirashima, Ming Wei, Olivier Morales, Bertrand Raynal, Nadira Delhem, Olivier Dellis, Pierre Busson

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2018, 13 (9), pp.e0202512. ⟨10.1371/journal.pone.0202512⟩
PLoS ONE, Vol 13, Iss 9, p e0202512 (2018)

International audience; Extra-cellular galectin-9 (gal-9) is an immuno-modulatory protein with predominant immuno-suppressive effects. Inappropriate production of gal-9 has been reported in several human malignancies and viral diseases like nasophary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cb53f9abe50394d89b97efe66af27424
https://pubmed.ncbi.nlm.nih.gov/30204750

Exposure of the HIV-1 broadly neutralizing antibody 10E8 MPER epitope on the membrane surface by gp41 transmembrane domain scaffolds

Autor: Beatriz Apellaniz, Carmen Domene, Edurne Rujas, Victoria Oakes, José L. Nieva, Johana Torralba

Publikováno v: Oakes, V, Torralba, J, Rujas, E, Nieva, J L, Domene, C & Apellaniz, B 2018, ' Exposure of the HIV-1 broadly neutralizing antibody 10E8 MPER epitope on the membrane surface by gp41 transmembrane domain scaffolds ', Biochimica et Biophysica Acta (BBA)-Biomembranes . https://doi.org/10.1016/j.bbamem.2018.02.019
Oakes, V, Torralba, J, Rujas, E, Nieva, J L, Domene, C & Apellaniz, B 2018, ' Exposure of the HIV-1 broadly neutralizing antibody 10E8 MPER epitope on the membrane surface by gp41 transmembrane domain scaffolds ', Biochimica et Biophysica Acta, vol. 1860, no. 6, pp. 1259-1271 . https://doi.org/10.1016/j.bbamem.2018.02.019

The 10E8 antibody achieves near-pan neutralization of HIV-1 by targeting the remarkably conserved gp41 membrane-proximal external region (MPER) and the connected transmembrane domain (TMD) of the HIV-1 envelope glycoprotein (Env). Thus, recreating th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e11a8f3f00a2aaf8fc069019238812
https://pubmed.ncbi.nlm.nih.gov/29477358

In Black Africans with rheumatoid arthritis, ACPA recognize citrullinated fibrinogen and the derived peptides α36-50Cit38,42 and β60-74Cit60,72,74, like in Caucasians

Autor: Sylvette Bas, Leonor Nogueira, Madeleine Singwe-Ngandeu, Guy Serre, Cem Gabay, Martin Cornillet, Sebastien Viatte

Publikováno v: Clinical Immunology
Clinical Immunology, Elsevier, 2014, 152 (1-2), pp.58-64. ⟨10.1016/j.clim.2014.02.011⟩
Clinical Immunology, Vol. 152, No 1-2 (2014) pp. 58-64

International audience; Well documented in Caucasians and Asians, the diagnostic value of anti-CCP2 antibodies has been confirmed in Black African populations. However, autoantibodies to other citrullinated peptides/proteins and their fine specificit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e015e6a4a675d50b46141093a618b4fb
https://doi.org/10.1016/j.clim.2014.02.011