A conformational epitope in placental malaria vaccine antigen VAR2CSA:What does it teach us?

Autor: Justin Y. A. Doritchamou, Jonathan P. Renn, Lars Hviid, Patrick E. Duffy

Publikováno v: Doritchamou, J Y A, Renn, J P, Hviid, L & Duffy, P E 2023, ' A conformational epitope in placental malaria vaccine antigen VAR2CSA : What does it teach us? ', PLoS Pathogens, vol. 19, no. 5, e1011370 . https://doi.org/10.1371/journal.ppat.1011370

VAR2CSA is the Plasmodium falciparum variant surface antigen that mediates binding of infected erythrocytes to chondroitin sulfate A (CSA) and their sequestration in intervillous spaces of the placenta, leading to placental malaria (PM). Relatively h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cfb8163852760950958f00197a7304b
https://curis.ku.dk/ws/files/347695012/journal.ppat.1011370.pdf

In Black Africans with rheumatoid arthritis, ACPA recognize citrullinated fibrinogen and the derived peptides α36-50Cit38,42 and β60-74Cit60,72,74, like in Caucasians

Autor: Sylvette Bas, Leonor Nogueira, Madeleine Singwe-Ngandeu, Guy Serre, Cem Gabay, Martin Cornillet, Sebastien Viatte

Publikováno v: Clinical Immunology
Clinical Immunology, Elsevier, 2014, 152 (1-2), pp.58-64. ⟨10.1016/j.clim.2014.02.011⟩
Clinical Immunology, Vol. 152, No 1-2 (2014) pp. 58-64

International audience; Well documented in Caucasians and Asians, the diagnostic value of anti-CCP2 antibodies has been confirmed in Black African populations. However, autoantibodies to other citrullinated peptides/proteins and their fine specificit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e015e6a4a675d50b46141093a618b4fb
https://doi.org/10.1016/j.clim.2014.02.011

Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry

Autor: Jürgen Cox, Katja Specht, Eva Bräunlein, Melanie Straub, Matthias Mann, Julia Weber, Angela M. Krackhardt, Julia Slotta-Huspenina, Christian Peschel, Pavel Sinitcyn, Michal Bassani-Sternberg, Richard Klar, Stefan Audehm, Roland Rad, Thomas Engleitner, Dirk H. Busch, Angelika Werner, Rüdiger Hein, Marc E. Martignoni

Publikováno v: Nature Communications
Nature communications, vol. 7, pp. 13404
Nature communications
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)

Although mutations may represent attractive targets for immunotherapy, direct identification of mutated peptide ligands isolated from human leucocyte antigens (HLA) on the surface of native tumour tissue has so far not been successful. Using advanced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0d44670b885c4a52836f1159fff028
https://pubmed.ncbi.nlm.nih.gov/27869121

Monoclonal antibody recognizing SLLTEVET epitope of M2 protein potently inhibited the replication of influenza A viruses in MDCK cells

Autor: Tianhou Wang, Licheng Zhou, Xu-Guang Xi, Hongwei Xu, Yongjin Wang, Xiaoming Wang, Huiling Shi, Tetsuya Toyoda, Hong Yao

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2009, 385 (1), pp.118-122. ⟨10.1016/j.bbrc.2009.04.129⟩

International audience; The ectodomain of influenza A virus M2 protein (M2e) is composed of 24 amino acids and induces antibodies with inhibitory effect against a broad spectrum of influenza A subtypes in vitro and in vivo. Although relatively conser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7a95a98173143b0356a0eba8357ae4
https://doi.org/10.1016/j.bbrc.2009.04.129

Effect of immune pressure on hepatitis C virus evolution: insights from a single-source outbreak

Autor: Susan McKiernan, Abha Chopra, Silvana Gaudieri, Andri Rauch, Dermot Kelleher, Elizabeth Freitas, Julia di Iulio, Mina John, Suzanne Norris, Paul Klenerman, Shahzma Merani, D. Cooper, Michaela Lucas, Ian James, Karen Fitzmaurice, Danijela Petrovic

Publikováno v: Hepatology, vol. 53, no. 2, pp. 396-405
Hepatology (Baltimore, Md.)

The host's immune response to hepatitis C virus (HCV) can result in the selection of characteristic mutations (adaptations) that enable the virus to escape this response. The ability of the virus to mutate at these sites is dependent on the incoming

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4f85f9d8e53a3431a1e78341881dd9
https://serval.unil.ch/resource/serval:BIB_49D614D469FB.P001/REF.pdf