Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Epitopes/chemistry"'
Autor:
Florian Krammer, Adam K. Wheatley, Allen C. Cheng, Kai Yan Mak, Jennifer A Juno, Glen P. Westall, Lilith F. Allen, Olivia C Smibert, Effie Mouhtouris, Lukasz Kedzierski, Louise C. Rowntree, Claire L. Gordon, Hyon-Xhi Tan, Jennifer R. Habel, Carolien E. van de Sandt, Fatima Amanat, Kathleen M. Wragg, Luca Hensen, Natasha E Holmes, Jan Petersen, Priyanka Chaurasia, Sabrina Sonda, Peter Harcourt, Joseph Torresi, Thi H. O. Nguyen, Katherine Kedzierska, Francesca L Mordant, Jamie Rossjohn, L. Earnest, Brendon Y. Chua, Jasveen Kaur, Jason A Trubiano, Katie L. Flanagan, Linda M. Wakim, Patrick Clifton, Stephen J. Kent, Paul G. Thomas, Nicole A. Mifsud, Denise L. Doolan, Wuji Zhang, Fiona L James, Jeremy Chase Crawford
Publikováno v:
Immunity
Immunity, 54(5), 1066-1082.e5. Cell Press
Immunity, 54(5), 1066-1082.e5. Cell Press
To better understand primary and recall T cell responses during COVID-19, it is important to examine unmanipulated SARS-CoV-2-specific T cells. Using peptide-HLA tetramers for direct ex vivo analysis, we characterized CD8+ T cells specific for SARS-C
Autor:
Amandine Bovay, Vincent Zoete, Daniel E. Speiser, Philippe Delbreil, Pierre J. Rizkallah, David K. Cole, Konrad Beck, Silvia A. Fuertes Marraco
Publikováno v:
Molecular immunology, vol. 125, pp. 43-50
The CD8 T cell response to the HLA-A2-restricted epitope LLWNGPMAV (LLW) of the non-structural protein 4b of Yellow Fever Virus (YFV) is remarkably immunodominant, highly prevalent and powerful in YFV-vaccinated humans. Here we used a combinatorial p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cdebc85543c1a1115afc50e5311e006
https://orca.cardiff.ac.uk/id/eprint/133295/1/Mol_Immunol_060720.pdf
https://orca.cardiff.ac.uk/id/eprint/133295/1/Mol_Immunol_060720.pdf
Autor:
Laura E. McCoy, Jeffrey Seow, Thomas A. Bowden, Helen M. E. Duyvesteyn, Jose M. Jimenez-Guardeño, Hataf Khan, Neophytos Kouphou, Yuguang Zhao, Marit J. van Gils, Yin Wu, Carl Graham, Peter Cherepanov, Maria Jose Lista, Adam Laing, Manu Shankar-Hari, Liane Dupont, Weng M Ng, Adrian Hayday, Stuart J. D. Neil, Michael H. Malim, Luke Muir, Sam Acors, Annachiara Rosa, Magdalene Joseph, Helena Winstone, Katie J. Doores, Rui Pedro Galão, Isabella Huettner, Suzanne Pickering
Publikováno v:
Immunity, 54(6), 1276-1289.e6. Cell Press
Immunity
Graham, C, Seow, J, Huettner, I, Khan, H, Kouphou, N, Acors, S, Winstone, H, Pickering, S, Galao, R P, Dupont, L, Lista, M J, Jimenez-Guardeño, J M, Laing, A G, Wu, Y, Joseph, M, Muir, L, van Gils, M J, Ng, W M, Duyvesteyn, H M E, Zhao, Y, Bowden, T A, Shankar-Hari, M, Rosa, A, Cherepanov, P, McCoy, L E, Hayday, A C, Neil, S J D, Malim, M H & Doores, K J 2021, ' Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant ', Immunity, vol. 54, no. 6, pp. 1276-1289.e6 . https://doi.org/10.1016/j.immuni.2021.03.023
Immunity
Graham, C, Seow, J, Huettner, I, Khan, H, Kouphou, N, Acors, S, Winstone, H, Pickering, S, Galao, R P, Dupont, L, Lista, M J, Jimenez-Guardeño, J M, Laing, A G, Wu, Y, Joseph, M, Muir, L, van Gils, M J, Ng, W M, Duyvesteyn, H M E, Zhao, Y, Bowden, T A, Shankar-Hari, M, Rosa, A, Cherepanov, P, McCoy, L E, Hayday, A C, Neil, S J D, Malim, M H & Doores, K J 2021, ' Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant ', Immunity, vol. 54, no. 6, pp. 1276-1289.e6 . https://doi.org/10.1016/j.immuni.2021.03.023
Interaction of the SARS-CoV-2 Spike receptor binding domain (RBD) with the receptor ACE2 on host cells is essential for viral entry. RBD is the dominant target for neutralizing antibodies, and several neutralizing epitopes on RBD have been molecularl
Autor:
Cornillet, Martin, Babos, Fruzsina, Magyar, Anna, Sebbag, Mireille, Verrouil, Evelyne, Hudecz, Ferenc, Serre, Guy, Nogueira, Leonor
Publikováno v:
Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2018, 201 (11), pp.3211-3217. ⟨10.4049/jimmunol.1800330⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2018, 201 (11), pp.3211-3217. ⟨10.4049/jimmunol.1800330⟩
International audience; Quantification of Abs toward a single epitope is critical to understanding immunobiological processes. In autoimmunity, the prognostic value of the serological profiles of patients draws much attention, but the detection of Ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c146dee0baed7c7fc6e8495d834741aa
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03156386
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03156386
Autor:
Siyu Luo, Yurong Wen, Serge Muyldermans, Fang Zheng, Patrick De Baetselier, Steve Schoonooghe, Geert Raes, Wuyuan Lu, Zhenlin Ouyang
Vsig4 is a recently identified immune regulatory protein related to the B7 family with dual functionality: a negative regulator of T cell activation and a receptor for the complement components C3b and C3c. Here we present a structural evaluation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c900e53cbc35e4065eabb5dfde916f6
https://doi.org/10.1016/j.imbio.2016.11.008
https://doi.org/10.1016/j.imbio.2016.11.008
Autor:
Celso A. Reis, Karol Polom, Charlotte Welinder, Lena Danielsson, Nicolai Stuhr-Hansen, Stefan Mereiter, András Kovács, Ola Blixt, António Polónia, Bo Jansson, Christian Risinger, Franco Roviello, Nina Persson
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Here, we introduce a novel scFv antibody, G2-D11, specific for two adjacent Tn-antigens (GalNAc- Ser/Thr) binding equally to three dimeric forms of the epitope, Ser-Thr, Thr-Thr and Thr-Ser. Compared to other anti-Tn reagents, the binding of G2-D11 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2010e9aa7fe5b17bd88ad77c7df2d6
https://hdl.handle.net/10216/119041
https://hdl.handle.net/10216/119041
Autor:
Tianhou Wang, Licheng Zhou, Xu-Guang Xi, Hongwei Xu, Yongjin Wang, Xiaoming Wang, Huiling Shi, Tetsuya Toyoda, Hong Yao
Publikováno v:
Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2009, 385 (1), pp.118-122. ⟨10.1016/j.bbrc.2009.04.129⟩
Biochemical and Biophysical Research Communications, Elsevier, 2009, 385 (1), pp.118-122. ⟨10.1016/j.bbrc.2009.04.129⟩
International audience; The ectodomain of influenza A virus M2 protein (M2e) is composed of 24 amino acids and induces antibodies with inhibitory effect against a broad spectrum of influenza A subtypes in vitro and in vivo. Although relatively conser
Autor:
Valérie Dutoit, Verena Rubio-Godoy, Mikäel J. Pittet, Alfred Zippelius, Pierre-Yves Dietrich, Frédérique Anne Legal, Philippe Guillaume, Pedro Romero, Jean-Charles Cerottini, Richard A. Houghten, Clemencia Pinilla, Danila Valmori
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, vol. 196, no. 2, pp. 207-216
Journal of Experimental Medicine, vol. 196, no. 2, pp. 207-216
In contrast with the low frequency of most single epitope reactive T cells in the preimmune repertoire, up to 1 of 1,000 naive CD8+ T cells from A2+ individuals specifically bind fluorescent A2/peptide multimers incorporating the A27L analogue of the
Autor:
Iveth J. González, Michelle L. Gatton, Nelson Lee, James S. McCarthy, Qin Cheng, Martin Bubb, Anita Pelecanos, David Bell
Publikováno v:
Journal of Clinical Microbiology
Rapid diagnostic tests (RDTs) represent important tools to diagnose malaria infection. To improve understanding of the variable performance of RDTs that detect the major target in Plasmodium falciparum , namely, histidine-rich protein 2 (HRP2), and t
Publikováno v:
Molecular Vision, Vol. 16 (2010) pp. 353-358
Molecular Vision
Molecular Vision
PURPOSE: Vogt-Koyanagi-Harada (VKH) disease and sympathetic ophthalmia (SO) are two distinct entities that share common clinical and histopathological features; however, it remains unknown whether they have a common genetic susceptibility. Several st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6150a896315272283688e63874bcf567
https://archive-ouverte.unige.ch/unige:21341
https://archive-ouverte.unige.ch/unige:21341