Výsledky vyhledávání - "Epithelial-Mesenchymal Transition/drug effects"

Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma

Publikováno v: Raggi, C, Taddei, M L, Sacco, E, Navari, N, Correnti, M, Piombanti, B, Pastore, M, Campani, C, Pranzini, E, Iorio, J, Lori, G, Lottini, T, Peano, C, Cibella, J, Lewinska, M, Andersen, J B, di Tommaso, L, Viganò, L, Di Maira, G, Madiai, S, Ramazzotti, M, Orlandi, I, Arcangeli, A, Chiarugi, P & Marra, F 2021, ' Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma ', Journal of Hepatology, vol. 74, no. 6, pp. 1373-1385 . https://doi.org/10.1016/j.jhep.2020.12.031

BACKGROUND & AIMS: Little is known about the metabolic regulation of cancer stem cells (CSCs) in cholangiocarcinoma (CCA). We analyzed whether mitochondrial-dependent metabolism and related signaling pathways contribute to stemness in CCA.METHODS: Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef501d3fbda1682299d6ec0832b7ea5
https://doi.org/10.1016/j.jhep.2020.12.031

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TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells

Autor: Yvan Larondelle, Charline Degavre, Laurenne Petit, Joao Pedro Santiago de Jesus, Carine Michiels, Chantal Dessy, Bastien Doix, Olivier Feron, Catherine Vander Linden, Céline Guilbaud, Ruben Martherus, Estelle Bastien, Cyril Corbet, Emeline Dierge

Publikováno v: Nature Communications, Vol. 11, no.1, p. 1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications

Acidosis, a common characteristic of the tumor microenvironment, is associated with alterations in metabolic preferences of cancer cells and progression of the disease. Here we identify the TGF-β2 isoform at the interface between these observations.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68950cb71c22ec4eb3d334e9c4db980b
https://hdl.handle.net/2078.1/226540

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Long-Term Vemurafenib Exposure Induced Alterations of Cell Phenotypes in Melanoma : Increased Cell Migration and Its Association with EGFR Expression

Autor: Marco Donia, Marcell Baranyi, Dominika Rittler, Walter Berger, Eszter Molnár, József Tímár, Balázs Hegedűs, Michael Grusch, Tamás Garay

Publikováno v: Molnár, E, Garay, T, Donia, M, Baranyi, M, Rittler, D, Berger, W, Tímár, J, Grusch, M & Hegedűs, B 2019, ' Long-Term Vemurafenib Exposure Induced Alterations of Cell Phenotypes in Melanoma : Increased Cell Migration and Its Association with EGFR Expression ', International Journal of Molecular Sciences, vol. 20, no. 18, 4484 . https://doi.org/10.3390/ijms20184484
International Journal of Molecular Sciences
Volume 20
Issue 18
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4484 (2019)

Acquired resistance during BRAF inhibitor therapy remains a major challenge for melanoma treatment. Accordingly, we evaluated the phenotypical and molecular changes of isogeneic human V600E BRAF-mutant melanoma cell line pairs pre- and post-treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c940f3bdc729af27e2d11c9360835c4c
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85072142127

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SNAI2 upregulation is associated with an aggressive phenotype in fulvestrant-resistant breast cancer cells and is an indicator of poor response to endocrine therapy in estrogen receptor-positive metastatic breast cancer

Autor: Henrik J. Ditzel, Daniel Elias, Martin Bak, Maria Bibi Lyng, Carla Maria Lourenco Alves

Publikováno v: Alves, C M L, Elias, D, Lyng, M B, Bak, M & Ditzel, H 2018, ' SNAI2 upregulation is associated with an aggressive phenotype in fulvestrant-resistant breast cancer cells and is an indicator of poor response to endocrine therapy in estrogen receptor-positive metastatic breast cancer ', Breast Cancer Research, vol. 20, 60 . https://doi.org/10.1186/s13058-018-0988-9
Breast Cancer Research : BCR
Breast Cancer Research, Vol 20, Iss 1, Pp 1-12 (2018)

Background Endocrine resistance in estrogen receptor-positive (ER+) breast cancer is a major clinical problem and is associated with accelerated cancer cell growth, increased motility and acquisition of mesenchymal characteristics. However, the speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9d7f336d2ff1a7d80a2e5a31621b6d
https://findresearcher.sdu.dk:8443/ws/files/141819899/Alves_et_al_2018_Breast_Cancer_Research.pdf

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Cyclin A2 modulates EMT via β-catenin and phospholipase C pathways

Autor: Abdallah Hamieh, Bénédicte Lemmers, Conception Paul, Youssef Anouar, Michael Hahne, Jean-Marie Blanchard, Caroline Cheung, Nawal Bendris

Publikováno v: Carcinogenesis
Carcinogenesis, Oxford University Press (OUP), 2015, 36 (8), pp.914--24. ⟨10.1093/carcin/bgv069⟩
Carcinogenesis, Oxford University Press (OUP), 2015, 36 (8), pp.914-924. ⟨10.1093/carcin/bgv069⟩

International audience; We have previously demonstrated that Cyclin A2 is involved in cytoskeletal dynamics, epithelial-mesenchymal transition (EMT) and metastasis. This phenotype was potentiated by activated oncogenic H-Ras. However, the mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70032f2825e65a3d3cf29538c58b3013
https://pubmed.ncbi.nlm.nih.gov/25993989

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Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells

Autor: Anne Yaël Nossent, Mikael Schneider, Hasse Brønnum, Solveig B. Nielsen, Ditte Caroline Andersen, Søren P. Sheikh

Publikováno v: Brønnum, H, Andersen, D C, Schneider, M, Yaël Nossent, A, Nielsen, S B & Sheikh, S P 2013, ' Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells ', Experimental Cell Research, vol. 319, no. 4, pp. 424-435 . https://doi.org/10.1016/j.yexcr.2012.12.019

Recent reports suggest that the adult epicardium is a source of cardiac progenitor cells having the ability to undergo epithelial-to-mesenchymal transition (EMT) and predominantly differentiate into myofibroblasts, thereby contributing to fibrosis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6420629bcc9bb638f5c6690cef4daf0e
https://pubmed.ncbi.nlm.nih.gov/23270756

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Defining new criteria for selection of cell-based intestinal models using publicly available databases

Autor: Hanifa Bouzourene, Pascale Anderle, Mauro Delorenzi, Sanna Siissalo, Susanne Bentz, Jon Christensen, Armando Felsani, Manuela Natoli, Thierry Sengstag, Michel Aguet, Piercarlo Saletti, Martín Rumbo, Maya R Vila, Jouni Hirvonen, Sara El-Gebali

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
BMC Genomics, vol. 13, pp. 274
BMC Genomics
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
BMC Genomics, Vol 13, Iss 1, p 274 (2012)
Christensen, Jon; El-Gebali, Sara; Natoli, Manuela; Sengstag, Thierry; Delorenzi, Mauro; Bentz, Susanne; Bouzourene, Hanifa; Rumbo, Martin; Felsani, Armando; Siissalo, Sanna; Hirvonen, Jouni; Vila, Maya R; Saletti, Piercarlo; Aguet, Michel; Anderle, Pascale (2012). Defining new criteria for selection of cell-based intestinal models using publicly available databases. BMC Genomics, 13, p. 274. London: BioMed Central 10.1186/1471-2164-13-274

Background: The criteria for choosing relevant cell lines among a vast panel of available intestinal-derived lines exhibiting a wide range of functional properties are still ill-defined. The objective of this study was, therefore, to establish object

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd2f9da2e4701e2167adb730c7ca6ec

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