Metformin suppresses epithelial sodium channel hyperactivation and its associated phenotypes in a mouse model of obstructive lung diseases

Autor: Ryunosuke Nakashima, Hirofumi Nohara, Noriki Takahashi, Aoi Nasu, Megumi Hayashi, Tomoki Kishimoto, Shunsuke Kamei, Haruka Fujikawa, Kasumi Maruta, Taisei Kawakami, Yuka Eto, Keiko Ueno-Shuto, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto

Publikováno v: Journal of Pharmacological Sciences, Vol 149, Iss 2, Pp 37-45 (2022)

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the world, and has no radical treatment. Inhibition of amiloride-sensitive epithelial sodium ion channel (ENaC) has now been considered as a potential therapeutic t

Externí odkaz: https://doaj.org/article/a3fdda52c3ac4d2197ce82bec8cd299c

Activation of SGK1 in Endometrial Epithelial Cells in Response to PI3K/AKT Inhibition Impairs Embryo Implantation

Autor: Madhuri S. Salker, Jennifer H. Steel, Zohreh Hosseinzadeh, Jaya Nautiyal, Zoe Webster, Yogesh Singh, Sara Brucker, Florian Lang, Jan J. Brosens

Publikováno v: Cellular Physiology and Biochemistry, Vol 39, Iss 5, Pp 2077-2087 (2016)

Background: Serum & Glucocorticoid Regulated Kinase 1 (SGK1) plays a fundamental role in ion and solute transport processes in epithelia. In the endometrium, down-regulation of SGK1 during the window of receptivity facilitates embryo implantation whe

Externí odkaz: https://doaj.org/article/ba2118b95081494d88db684b0225b511

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Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway

Autor: Lang, Florian, Pearce, David

Publikováno v: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association-European Renal Association, vol 31, iss 2

The epithelial Na(+) channel (ENaC) is decisive for sodium reabsorption by the aldosterone-sensitive distal nephron (ASDN) of the kidney. ENaC is regulated by the serum- and glucocorticoid-inducible kinase 1 (SGK1), a kinase genomically upregulated b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::684c1b9df53c92b624c891083d7a953a
https://escholarship.org/uc/item/4vv7t92d

Glucocorticoids can activate the α-ENaC gene promoter independently of SGK1

Autor: Stuart M. Wilson, Jennet Getty, Ann Burchell, Niall McTavish

Publikováno v: Biochemical Journal

The role of SGK1 (serum- and glucocorticoid-induced protein kinase 1) in the glucocorticoid induction of alpha-ENaC (epithelial Na+ channel alpha subunit) gene transcription was explored by monitoring the transcriptional activity of a luciferase-link

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3d75ac60a7a5ca85f0648715f23ca5
https://doi.org/10.1042/bj20090366