Acute cigarette smoke‐induced eQTL affects formyl peptide receptor expression and lung function

Autor: Maarten van den Berge, Nick H. T. ten Hacken, Simon D. Pouwels, Irene H. Heijink, Marijn Berg, Immeke E. Fokkema, Alen Faiz, Valerie R. Wiersma

Publikováno v: Respirology, 26(3), 233-240. Wiley
Respirology (Carlton, Vic.)

A candidate‐based inducible eQTL study was performed in occasional smokers, identifying rs3212855 flanking the FPR as novel cigarette smoke‐induced eQTL. In addition, rs3212855 was associated with lower lung function. Lastly, CRISPR‐Cas9‐down

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de89ea735fa91986aa7b9780f768879b
https://doi.org/10.1111/resp.13960

Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny

Autor: Davis, Felicity M, Lloyd-Lewis, Bethan, Harris, Olivia B, Kozar, Sarah, Winton, Douglas J, Muresan, Leila, Watson, Christine J

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Davis, F M, Lloyd-Lewis, B, Harris, O B, Kozar, S, Winton, D J, Muresan, L & Watson, C J 2016, ' Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny ', Nature Communications, vol. 7, 13053 (2016) . https://doi.org/10.1038/ncomms13053

The mammary gland undergoes cycles of growth and regeneration throughout reproductive life, a process that requires mammary stem cells (MaSCs). Whilst recent genetic fate-mapping studies using lineage-specific promoters have provided valuable insight

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babd393756ccbc5bc5cad42a2301a420

Human alpha-defensin-1 protects cells from intoxication with Clostridium perfringens iota toxin

Autor: Stephan Fischer, Holger Barth, Michel R. Popoff

Publikováno v: Pathogens and Disease
Pathogens and Disease, Oxford University Press, 2018, 76 (2), ⟨10.1093/femspd/fty022⟩
Pathogens and Disease, 2018, 76 (2), ⟨10.1093/femspd/fty022⟩

International audience; Iota toxin is produced by Clostridium perfringens type E strains and associated with diarrhea in cattle and lambs. This binary protein toxin comprises the enzyme component iota a (Ia), which ADP-ribosylates G-actin, and the se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c070175e22613b118afd726cbc2fcfd
https://pubmed.ncbi.nlm.nih.gov/29635426

A Morphometric Study of Mechanotransductively Induced Dermal Neovascularization

Autor: Robert J. D'Amato, Avner Adini, Paolo Erba, Britlyn D. Orgill, Maximilian Ackermann, Lino F. Miele, Dennis P. Orgill, Steven J. Mentzer, James M Lamarche, Moritz A. Konerding

Publikováno v: Plastic and Reconstructive Surgery, vol. 128, no. 4, pp. 288e-299e

BACKGROUND:: Mechanical stretch has been shown to induce vascular remodeling and increase vessel density, but the pathophysiologic mechanisms and the morphologic changes induced by tensile forces to dermal vessels are poorly understood. METHODS:: A c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b6bb699dfff15c745686168c3ccaa6
https://doi.org/10.1097/prs.0b013e3182268b19

Aurora A triggers Lgl cortical release during symmetric division to control planar spindle orientation

Autor: Cátia A. Carvalho, Eurico Morais-de-Sá, Claudio E. Sunkel, Guilherme Ventura, Sofia Moreira

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Mitotic spindle orientation is essential to control cell-fate specification and epithelial architecture. The tumor suppressor Lgl localizes to the basolateral cortex of epithelial cells, where it acts together with Dlg and Scrib to organize apicobasa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19593f0cfb0e4ba1492d5a7afde624b1