Assembly and organization of the N-terminal region of mucin MUC5AC:Indications for structural and functional distinction from MUC5B

Autor: Camille Ehre, Lisa C. Morton, Mehmet Kesimer, Caroline Ridley, Wanda K. O'Neal, David J. Thornton, Marie-Pierre Buisine, Richa Gupta, Jerome Carpenter, Durai B. Subramani, Boris Reidel, Yang Wang, Yuanli Li, Prashamsha Haridass

Publikováno v: Carpenter, J, Wang, Y, Gupta, R, Li, Y, Haridass, P, Subramani, D B, Reidel, B, Morton, L, Ridley, C, O'Neal, W K, Buisine, M-P, Ehre, C, Thornton, D J & Kesimer, M 2021, ' Assembly and organization of the N-terminal region of mucin MUC5AC : Indications for structural and functional distinction from MUC5B ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 39, e2104490118 . https://doi.org/10.1073/pnas.2104490118
Proc Natl Acad Sci U S A

Elevated levels of MUC5AC, one of the major gel-forming mucins in the lungs, are closely associated with chronic obstructive lung diseases such as chronic bronchitis and asthma. It is not known, however, how the structure and/or gel-making properties

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78827d88939a7e4d210e78ceaa63a356
https://doi.org/10.1073/pnas.2104490118

Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium

Autor: Cagnet, Stéphanie, Ataca, Dalya, Sflomos, George, Aouad, Patrick, Schuepbach-Mallepell, Sonia, Hugues, Henry, Krust, Andrée, Ayyanan, Ayyakkannu, Scabia, Valentina, Brisken, Cathrin

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature communications, vol. 9, no. 1, pp. 4723
Nature Communications
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-07175-0⟩

Oestrogen receptor α (ERα) is a transcription factor with ligand-independent and ligand-dependent activation functions (AF)-1 and -2. Oestrogens control postnatal mammary gland development acting on a subset of mammary epithelial cells (MECs), term

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::37eac31573f29d80222640b3da063824
http://link.springer.com/article/10.1038/s41467-018-07175-0

Fabrication of Kidney Proximal Tubule Grafts Using Biofunctionalized Electrospun Polymer Scaffolds

Autor: Jansen, Katja, Castilho, Miguel, Aarts, Sanne, Kaminski, Michael M, Lienkamp, Soeren S, Pichler, Roman, Malda, Jos, Vermonden, Tina, Jansen, Jitske, Masereeuw, Rosalinde, Afd Pharmacology, LS Equine Muscoskeletal Biology, Afd Pharmaceutics, Pharmacology, Pharmaceutics, dES RMSC

Publikováno v: Macromolecular Bioscience, 19(2). Wiley-VCH Verlag
Macromolecular Bioscience, 19(2):1800412. Wiley-VCH Verlag
Macromolecular Bioscience, 19, 2
Macromolecular Bioscience
Macromolecular Bioscience, 19
Macromolecular bioscience

The increasing prevalence of end-stage renal disease and persistent shortage of donor organs call for alternative therapies for kidney patients. Dialysis remains an inferior treatment as clearance of large and protein-bound waste products depends on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce61bf231f59706d35baa4044fa7738
https://dspace.library.uu.nl/handle/1874/389617

Growth of endothelial cells in space and in simulated microgravity : a comparison on the secretory level

Autor: Thomas J. Corydon, Matthias Evert, Markus Wehland, Marcel Egli, Stefano Nebuloni, Jessica Pietsch, Johann Bauer, Daniel Grimm, Daniel T O Carvalho, Sara Dam Kobberø, Daniela Melnik, Manfred Infanger, Marjan Moreels, Marcus Krüger, Sarah Baatout, Samuel Gass, Sahana Jayashree, Sascha Kopp

Publikováno v: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
Krüger, M, Pietsch, J, Bauer, J, Kopp, S, Carvalho, D T O, Baatout, S, Moreels, M, Melnik, D, Wehland, M, Egli, M, Jayashree, S, Kobberø, S D, Corydon, T J, Nebuloni, S, Gass, S, Evert, M, Infanger, M & Grimm, D 2019, ' Growth of Endothelial Cells in Space and in Simulated Microgravity-a Comparison on the Secretory Level ', Cellular Physiology and Biochemistry, vol. 52, no. 5, pp. 1039-1060 . https://doi.org/10.33594/000000071
Cellular Physiology and Biochemistry, Vol 52, Iss 5, Pp 1039-1060 (2019)

BACKGROUND/AIMS: Endothelial cells exposed to the Random Positioning Machine (RPM) reveal three different phenotypes. They grow as a two-dimensional monolayer and form three-dimensional (3D) structures such as spheroids and tubular constructs. As par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55180934e6dec7131ad24fe9e5dccb5
https://hdl.handle.net/1854/LU-8612681

Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation

Autor: Brett Ba Shook, Victoria L. Seewaldt, Eve Roth, Michael C. Rudolph, Alexandra Van Keymeulen, Stephanie L. Kwei, Rachel K. Zwick, Brandon Holtrup, Matthew Ms Rodeheffer, Valerie Horsley, John J. Wysolmerski, Vivian Lei

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature communications, 9 (1

Adipocytes undergo pronounced changes in size and behavior to support diverse tissue functions, but the mechanisms that control these changes are not well understood. Mammary gland-associated white adipose tissue (mgWAT) regresses in support of milk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940b758e6418a93c49b0f6650d3ca620
https://doi.org/10.1038/s41467-018-05911-0