The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability

Autor: Jennifer Derrien, Catherine Guérin-Charbonnel, Victor Gaborit, Loïc Campion, Magali Devic, Elise Douillard, Nathalie Roi, Hervé Avet-Loiseau, Olivier Decaux, Thierry Facon, Jan-Philipp Mallm, Roland Eils, Nikhil C. Munshi, Philippe Moreau, Carl Herrmann, Florence Magrangeas, Stéphane Minvielle

Publikováno v: Genome Medicine, Vol 13, Iss 1, Pp 1-21 (2021)

Abstract Background Cancer evolution depends on epigenetic and genetic diversity. Historically, in multiple myeloma (MM), subclonal diversity and tumor evolution have been investigated mostly from a genetic perspective. Methods Here, we performed an

Externí odkaz: https://doaj.org/article/4a911b1129d149468316660d33d6e2e4

The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability

Autor: Jennifer Derrien, Catherine Guérin-Charbonnel, Victor Gaborit, Loïc Campion, Magali Devic, Elise Douillard, Nathalie Roi, Hervé Avet-Loiseau, Olivier Decaux, Thierry Facon, Jan-Philipp Mallm, Roland Eils, Nikhil C. Munshi, Philippe Moreau, Carl Herrmann, Florence Magrangeas, Stéphane Minvielle

Publikováno v: Genome Medicine
Genome Medicine, BioMed Central, 2021, 13 (1), ⟨10.1186/s13073-021-00938-3⟩
Genome Medicine, 2021, 13 (1), ⟨10.1186/s13073-021-00938-3⟩
Genome Medicine, Vol 13, Iss 1, Pp 1-21 (2021)

Background Cancer evolution depends on epigenetic and genetic diversity. Historically, in multiple myeloma (MM), subclonal diversity and tumor evolution have been investigated mostly from a genetic perspective. Methods Here, we performed an analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e399c09b39facc0962bc2d48b27be406
https://pubmed.ncbi.nlm.nih.gov/34372935

Tracking the evolution of epialleles during neural differentiation and brain development: D-Aspartate oxidase as a model gene

Autor: Maria Josè Sisalli, Luca Colucci-D'Amato, Antonella Monticelli, Francesco Errico, Gabriella Minchiotti, Francesca Boscia, Lorenzo Chiariotti, Vittorio Enrico Avvedimento, Simona Keller, Annalisa Fico, Alessandro Usiello, Antonella Scorziello, Ornella Affinito, Sergio Cocozza, Lorena Coretti, Ermanno Florio, Francesca Lembo, Giovanni Scala, Mafalda Giovanna Reccia, Gennaro Miele

Publikováno v: Epigenetics 12 (2017): 41–54. doi:10.1080/15592294.2016.1260211
info:cnr-pdr/source/autori:Florio, Ermanno; Keller, Simona; Coretti, Lorena; Affinito, Ornella; Scala, Giovanni; Errico, Francesco; Fico, Annalisa; Boscia, Francesca; Sisalli, Maria Jose; Reccia, Mafalda Giovanna; Miele, Gennaro; Monticelli, Antonella; Scorziello, Antonella; Lembo, Francesca; Colucci-D'Amato, Luca; Minchiotti, Gabriella; Avvedimento, Vittorio Enrico; Usiello, Alessandro; Cocozza, Sergio; Chiariotti, Lorenzo/titolo:Tracking the evolution of epialleles during neural differentiation and brain development: D-Aspartate oxidase as a model gene./doi:10.1080%2F15592294.2016.1260211/rivista:Epigenetics/anno:2017/pagina_da:41/pagina_a:54/intervallo_pagine:41–54/volume:12
Epigenetics

We performed ultra-deep methylation analysis at single molecule level of the promoter region of developmentally regulated D-Aspartate oxidase (Ddo), as a model gene, during brain development and embryonic stem cell neural differentiation. Single mole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc2147713d7bcf059e2c976df68fe1f
http://hdl.handle.net/11588/655423

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