The immune factors driving DNA methylation variation in human blood

Autor: Bergstedt, Jacob, Azzou, Sadoune Ait Kaci, Tsuo, Kristin, Jaquaniello, Anthony, Urrutia, Alejandra, Rotival, Maxime, Lin, David, Macisaac, Julia, Kobor, Michael, Albert, Matthew, Duffy, Darragh, Patin, Etienne, Quintana-Murci, Lluís, Intérieur Consortium, Milieu

Publikováno v: Nature Communications
Nature Communications, 2022, 13 (1), pp.5895. ⟨10.1038/s41467-022-33511-6⟩

Epigenetic changes are required for normal development, yet the nature and respective contribution of factors that drive epigenetic variation in humans remain to be fully characterized. Here, we assessed how the blood DNA methylome of 884 adults is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565efb84a7a5053661b6a2ed5551f9eb
https://hal-pasteur.archives-ouvertes.fr/pasteur-03865045/document

Large-Scale Multi-Omics Studies Provide New Insights into Blood Pressure Regulation

Autor: Kamali, Zoha, Keaton, Jacob M., Javanmard, Shaghayegh Haghjooy, Edwards, Todd L., Snieder, Harold, Vaez, Ahmad, Boomsma, Dorret, de Geus, Eco J.C., Hottenga, Jouke Jan, Willemsen, Gonneke, van Dongen, Jenny, Pool, René, Jansen, Rick, Penninx, Brenda WJH

Publikováno v: International Journal of Molecular Sciences, 23(14):7557. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7557
International Journal of Molecular Sciences, 23(14):7557. MDPI AG
Kamali, Z, Keaton, J M, Javanmard, S H, Edwards, T L, Snieder, H, Vaez, A, International Consortium of Blood Pressure, Million Veteran Program, eQTLGen Consortium, BIOS Consortium, Boomsma, D, de Geus, E J C, Hottenga, J J, Willemsen, G, van Dongen, J, Pool, R, Jansen, R & Penninx, B WJH 2022, ' Large-Scale Multi-Omics Studies Provide New Insights into Blood Pressure Regulation ', International Journal of Molecular Sciences, vol. 23, no. 14, 7557 . https://doi.org/10.3390/ijms23147557

Recent genome-wide association studies uncovered part of blood pressure’s heritability. However, there is still a vast gap between genetics and biology that needs to be bridged. Here, we followed up blood pressure genome-wide summary statistics of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842c8f8ad50e82045f1908accb36a76b
https://research.rug.nl/en/publications/73ff27d1-3ee1-4c63-8eb8-f5ef1ccd6e79

Gendered imaginaries: situating knowledge of epigenetic programming of health

Autor: Francesco Panese, Luca Chiapperino

Publikováno v: Sociology of health & illness, vol. 40, no. 7, pp. 1233-1249

Our paper explores the value-laden and epistemic resources that scientists working in epigenetics and developmental programming of health and disease (DOHaD) mobilise to produce scientific representations of pregnancy and parenthood, which in turn im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc738674470875c46b69646886d8c11f
https://doi.org/10.1111/1467-9566.12779

Evaluation of commonly used analysis strategies for epigenome- and transcriptome-wide association studies through replication of large-scale population studies

Autor: Lude Franke, Jeroen van Rooij, B.T. Heijmans, Jenny van Dongen, Rick Jansen, Pooja R. Mandaviya, Janine F. Felix, Joyce B. J. van Meurs, Peter A C 't Hoen, Annique Claringbould

Publikováno v: Genome Biology
Van Rooij, J, Mandaviya, P R, Claringbould, A, Felix, J F, Van Dongen, J, Jansen, R, Franke, L, Hoen, P A C, Heijmans, B & Van Meurs, J B J 2019, ' Evaluation of commonly used analysis strategies for epigenome-A nd transcriptome-wide association studies through replication of large-scale population studies ', Genome Biology, vol. 20, no. 1, 235 . https://doi.org/10.1186/s13059-019-1878-x
van Rooij, J, Mandaviya, P R, Claringbould, A, Felix, J F, van Dongen, J, Jansen, R, Franke, L, 't Hoen, P A C, Heijmans, B, van Meurs, J B J & BIOS Consortium 2019, ' Evaluation of commonly used analysis strategies for epigenome-and transcriptome-wide association studies through replication of large-scale population studies ', Genome Biology, vol. 20, no. 1, 235, pp. 235 . https://doi.org/10.1186/s13059-019-1878-x
Genome Biology, 20(1):235. BioMed Central Ltd.
Genome Biology, 20(1). BMC
Genome Biology, 20(1):235. BioMed Central Ltd
Genome Biology, 20(1):235
Genome Biology, 20
Genome Biology, 20(1):235. Springer Verlag
Genome Biology, 20(1):235. BMC
Genome Biology, Vol 20, Iss 1, Pp 1-14 (2019)
Genome Biology, 20, 1

Background A large number of analysis strategies are available for DNA methylation (DNAm) array and RNA-seq datasets, but it is unclear which strategies are best to use. We compare commonly used strategies and report how they influence results in lar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d80ef579a6a84d129693c7df5e1c53
https://doi.org/10.1186/s13059-019-1878-x

Epigenomic profiling of newborns with isolated orofacial clefts reveals widespread DNA methylation changes and implicates metastable epiallele regions in disease risk

Autor: Mark R. Segal, Jasper Rine, Semira Gonseth, Gary M. Shaw, Ritu Roy, Nicholas J. Marini, Joseph L. Wiemels, Kripa Asrani

Publikováno v: Epigenetics, vol 14, iss 2
Epigenetics
Epigenetics, vol. 14, no. 2, pp. 198-213

Cleft lip with or without cleft palate (CL/P) is a common human birth defect whose etiologies remain largely unknown. Several studies have demonstrated that periconceptional supplementation of folic acid can reduce risk of CL/P in offspring. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b348783b2ac15eb951bce0d58b0772
https://escholarship.org/uc/item/1k0481c5