Zobrazeno 1 - 10
of 962
pro vyhledávání: '"Epigenome-wide association study"'
Autor:
Jiafei Wu, Victoria Palasantzas, Sergio Andreu-Sánchez, Torsten Plösch, Sam Leonard, Shuang Li, Marc Jan Bonder, Harm-Jan Westra, Joyce van Meurs, Mohsen Ghanbari, Lude Franke, Alexandra Zhernakova, Jingyuan Fu, Joanne A. Hoogerland, Daria V. Zhernakova
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Background The plasma metabolome reflects the physiological state of various biological processes and can serve as a proxy for disease risk. Plasma metabolite variation, influenced by genetic and epigenetic mechanisms, can also affect the ce
Externí odkaz:
https://doaj.org/article/9ba2686e25cc4689806e48f764522f07
Autor:
Varun B. Dwaraka, Lucia Aronica, Natalia Carreras-Gallo, Jennifer L. Robinson, Tayler Hennings, Matthew M. Carter, Michael J. Corley, Aaron Lin, Logan Turner, Ryan Smith, Tavis L. Mendez, Hannah Went, Emily R. Ebel, Erica D. Sonnenburg, Justin L. Sonnenburg, Christopher D. Gardner
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Geroscience focuses on interventions to mitigate molecular changes associated with aging. Lifestyle modifications, medications, and social factors influence the aging process, yet the complex molecular mechanisms require an in-dep
Externí odkaz:
https://doaj.org/article/869a3e24e5c04b8ab44dadf995536283
Autor:
Rosana Carvalho Silva, Paolo Martini, Christa Hohoff, Stefania Mattevi, Marco Bortolomasi, Maria Abate, Valentina Menesello, Massimo Gennarelli, Bernhard T. Baune, Alessandra Minelli
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background Electroconvulsive therapy (ECT) benefits patients with treatment-resistant depression (TRD), but the underlying biological processes are unclear. We conducted an epigenome-wide association study in 32 TRD patients undergoing ECT t
Externí odkaz:
https://doaj.org/article/031dcce795c94b22a5850eeb4717c714
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background While multiple studies have investigated the relationship between metabolic syndrome (MetS) and its related traits (fasting glucose, triglyceride, HDL cholesterol, blood pressure, waist circumference) and DNA methylation, our unde
Externí odkaz:
https://doaj.org/article/676ef5bbb1e84ff6ab1fe416a1d919f2
Autor:
Mark Ziemann, Mandhri Abeysooriya, Anusuiya Bora, Séverine Lamon, Mary Sravya Kasu, Mitchell W. Norris, Yen Ting Wong, Jeffrey M. Craig
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
Infinium Methylation BeadChip arrays remain one of the most popular platforms for epigenome-wide association studies, but tools for downstream pathway analysis have their limitations. Functional class scoring (FCS) is a group of pathway enrichment te
Externí odkaz:
https://doaj.org/article/d2542601d7ed49bda4a91de1d496cb20
Autor:
Mohammed El Sharkawy, Janine F. Felix, Veit Grote, Trudy Voortman, Vincent W. V. Jaddoe, Berthold Koletzko, Leanne K. Küpers
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
ABSTRACTBackground Higher early-life animal protein intake is associated with a higher childhood obesity risk compared to plant protein intake. Differential DNA methylation may represent an underlying mechanism.Methods We analysed associations of inf
Externí odkaz:
https://doaj.org/article/b9ef9a33e0904341869d5487313fcb1a
Autor:
Lauren A. Opsasnick, Wei Zhao, Lauren L. Schmitz, Scott M. Ratliff, Jessica D. Faul, Xiang Zhou, Belinda L. Needham, Jennifer A. Smith
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
ABSTRACTLong-term psychosocial stress is strongly associated with negative physical and mental health outcomes, as well as adverse health behaviours; however, little is known about the role that stress plays on the epigenome. One proposed mechanism b
Externí odkaz:
https://doaj.org/article/04f3785273ba4e10a94695f80ad8e854
Autor:
Rosana Carvalho Silva, Paolo Martini, Christa Hohoff, Stefania Mattevi, Marco Bortolomasi, Valentina Menesello, Massimo Gennarelli, Bernhard T. Baune, Alessandra Minelli
Publikováno v:
European Journal of Psychotraumatology, Vol 15, Iss 1 (2024)
ABSTRACTBackground: Stressful events increase the risk for treatment-resistant depression (TRD), and trauma-focused psychotherapy can be useful for TRD patients exposed to early life stress (ELS). Epigenetic processes are known to be related to depre
Externí odkaz:
https://doaj.org/article/552a2263556f4a87bd22689f1b7668fc
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
ABSTRACTDNA methylation has been extensively utilized to study epigenetic patterns across many diseases as well as to deconvolve blood cell type proportions. This study builds upon previous studies examining methylation patterns in paediatric patient
Externí odkaz:
https://doaj.org/article/64a42ab9c7754acd8d99e08ff9999d68
Autor:
Sujin Seo, Ye An Kim, Young Lee, Young Jin Kim, Bong-Jo Kim, Jae Hoon An, Heejin Jin, Ah Ra Do, Kyungtaek Park, Sungho Won, Je Hyun Seo
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Conflicting findings have been reported regarding the association between Agent Orange (AO) exposure and type 2 diabetes. This study aimed to examine whether AO exposure is associated with the development of type 2 diabetes and to verify the causal r
Externí odkaz:
https://doaj.org/article/69a99ea84efe464ba2ed45d531578362