Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Epigenetics of cocaine addiction"'
Autor:
Rachel D. Penrod, Makoto Taniguchi, Stephanie A. Maddox, Jaswinder Kumar, Christopher W. Cowan, Maria B. Carreira
Publikováno v:
Addiction Biology. 23:653-664
Epigenetic mechanisms have been proposed to contribute to persistent aspects of addiction-related behaviors. One family of epigenetic molecules that may regulate maladaptive behavioral changes produced by cocaine use are the histone deacetylases (HDA
Publikováno v:
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
BACKGROUND The aim of this study was to explore how changes in the expression of BDNF in MLDS change the effect of BDNF on dopamine (DA) neurons, which may have therapeutic implications for heroin addiction. MATERIAL AND METHODS We established a rat
Autor:
Li Shen, Ning-Yi Shao, HaoSheng Sun, Gustavo Turecki, Mohamed Kabbaj, Jacqui Rabkin, Caroline Dias, Diane M. Damez-Werno, Kimberly N. Scobie, Rachael L. Neve, Ezekiell Mouzon, Katherine N. Wright, Eric J. Nestler
Publikováno v:
Neuroscience. 353:1-6
Chromatin regulation, in particular ATP-dependent chromatin remodelers, have previously been shown to be important in the regulation of reward-related behaviors in animal models of mental illnesses. Here we demonstrate that BAZ1A, an accessory subuni
Autor:
T. Chase Francis, Michel Engeln, Prasad Konkalmatt, Dipal Patel, Ramesh Chandra, Mary Kay Lobo
Publikováno v:
Biological Psychiatry. 81:564-572
Background Molecules critically involved in cocaine behavioral plasticity are known to regulate and interact with peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α). In addition, the PGC-1α promoter has binding sites for earl
Autor:
Dalton James Surmeier, Ko Woon Lee, Paul Greengard, Eric J. Nestler, Steven M. Graves, Yong Kim, Angus C. Nairn, Ilaria Ceglia, Michael E. Cahill, David M. Dietz
Publikováno v:
Proceedings of the National Academy of Sciences. 114:1395-1400
Wiskott-Aldrich syndrome protein (WASP) family verprolin homologous protein 1 (WAVE1) regulates actin-related protein 2/3 (Arp2/3) complex-mediated actin polymerization. Our previous studies have found WAVE1 to be inhibited by Cdk5-mediated phosphory
Autor:
J. M. Moalic, Naguib Mechawar, Gustavo Turecki, Florence Noble, Michel Simonneau, Sandrine Imbeaud, Philip Gorwood, Gilles Maussion, Sabah Kelaï, Nicolas Ramoz
Publikováno v:
Addiction Biology. 23:448-460
Netrin G1 is a presynaptic ligand involved in axonal projection. Although molecular mechanisms underlying cocaine addiction are still poorly understood, Netrin G1 might have a role as a regulator of anxiety, fear and spatial memory, behavioural trait
Publikováno v:
Behavioural Brain Research. 317:218-225
The aim of this study was to investigate the intracellular responses associated with the acquisition and expression of cocaine-context associations. ERK (extracellular regulated kinase), CREB (cAMP responsive element binding protein), FosB and ΔFosB
Autor:
David M. Dietz, Aaron Caccamise, Jennifer A. Martin, Lauren E. Mueller, Craig T. Werner, Amy M. Gancarz, Zi-Jun Wang, Jun-Xu Li, Rachael L. Neve
Publikováno v:
Biological Psychiatry. 80:652-660
Background Drug addiction is defined as a chronic disease characterized by compulsive drug seeking and episodes of relapse despite prolonged periods of drug abstinence. Neurobiological adaptations, including transcriptional and epigenetic alterations
Autor:
Qing-song Liu, Christopher M. Olsen
Publikováno v:
Frontiers in Biology. 11:376-386
Long-term exposure to drugs of abuse causes an up-regulation of the cAMP-signaling pathway in the nucleus accumbens and other forebrain regions, this common neuroadaptation is thought to underlie aspects of drug tolerance and dependence. Phosphodiest
Autor:
Diane M. Damez-Werno, Caroline Dias, Rachael L. Neve, Ning-Yi Shao, Gustavo Turecki, Jaclyn Rabkin, Mary Kay Lobo, Yasmin L. Hurd, C. David Allis, Ernesto Guccione, Ian Maze, Michael E. Cahill, David M. Dietz, Hannah M. Cates, Amy M. Gancarz, Ezekiell Mouzon, Joseph A. Landry, HaoSheng Sun, Ramesh Chandra, Catherine Jensen Pena, Kimberly N. Scobie, Eric J. Nestler, Paola Defilippi, Deena M. Walker, Erin S. Calipari, Li Shen
Publikováno v:
Proceedings of the National Academy of Sciences. 113:9623-9628
Repeated cocaine exposure regulates transcriptional regulation within the nucleus accumbens (NAc), and epigenetic mechanisms-such as histone acetylation and methylation on Lys residues-have been linked to these lasting actions of cocaine. In contrast