Zobrazeno 1 - 10
of 335
pro vyhledávání: '"Epigenetics in learning and memory"'
Autor:
Yeonghoon Son, Jong-Choon Kim, Joong Sun Kim, Juhwan Kim, Sung-Ho Kim, Sueun Lee, Sohi Kang, Miyoung Yang, Changjong Moon, Uhee Jung
Publikováno v:
Neuroscience Letters. 657:113-119
Brain exposure to ionizing radiation can cause functional deficits in the hippocampus, including memory impairment. However, the specific molecular mechanisms underlying irradiation-induced cognitive impairments are largely unknown. Changes in DNA me
Neuronal DNA Methyltransferases: Epigenetic Mediators between Synaptic Activity and Gene Expression?
Autor:
Michael R. Kreutz, Gonca Bayraktar
Publikováno v:
The neuroscientist, Online First
The Neuroscientist
The Neuroscientist
DNMT3A and 3B are the main de novo DNA methyltransferases (DNMTs) in the brain that introduce new methylation marks to non-methylated DNA in postmitotic neurons. DNA methylation is a key epigenetic mark that is known to regulate important cellular pr
Publikováno v:
Neurobiology of Learning and Memory. 141:1-8
Co-housing with a company exerts profound effects on memory decline in animal model of Alzheimer's disease (AD). Recently, we found that APP/PS1 mice of 9-month-old improved their memories after co-housing with wide-type mice for 3months by increasin
Autor:
L. N. Grinkevich, O. V. Vorobiova
Publikováno v:
Russian Journal of Genetics: Applied Research. 7:273-280
The epigenetic modifications of histones have been studied intensively to understand the mechanisms of long-term memory. Previously, we have shown that histone H3 methylation at the activation (H3K4me3) and inhibition (H3K9me2) sites plays an importa
Publikováno v:
Alcohol. 60:83-94
Alcohol-use disorder (AUD) is a relapsing disorder associated with excessive ethanol consumption. Recent studies support the involvement of epigenetic mechanisms in the development of AUD. Studies carried out so far have focused on a few specific epi
Autor:
Yue Wang, Fan Yi, Ying-Xiao Zhu, Zhe-Yu Chen, Jin-Kai Sun, Wen-Hai Sui, Xu-Feng Xu, Shuai Wang, Xu Jing, Xiao-Rong Chen, Rong-rong Yuan, Hui-Xian Ma
Publikováno v:
The Journal of Neuroscience. 37:3848-3863
Histone acetylation, an epigenetic modification, plays an important role in long-term memory formation. Recently, histone deacetylase (HDAC) inhibitors were demonstrated to promote memory formation, which raises the intriguing possibility that they m
Autor:
Tiffani D.M. Berkel, Subhash C. Pandey
Publikováno v:
Alcoholism: Clinical and Experimental Research. 41:666-680
Alcohol use disorder (AUD) is a complex brain disorder with an array of persistent behavioral and neurochemical manifestations. Both genetic and environmental factors are known to contribute to the development of AUD, and recent studies on alcohol ex
Autor:
Aroa Baragaño Raneros, Beatriz Suarez-Alvarez, Ana M. Aransay, José Luis Lavín, David Mosen-Ansorena, Leonardo Márquez-Kisinousky, Ramon M. Rodriguez, Carlos López-Larrea
Publikováno v:
The Journal of Immunology. 198:937-949
Epigenetic mechanisms play a critical role during differentiation of T cells by contributing to the formation of stable and heritable transcriptional patterns. To better understand the mechanisms of memory maintenance in CD8+ T cells, we performed ge
Publikováno v:
Psychiatry and Clinical Neurosciences. 70:536-550
The mammalian brain dynamically activates or silences gene programs in response to environmental input and developmental cues. This neuroplasticity is controlled by signaling pathways that modify the activity, localization, and/or expression of trans
Autor:
Kyle Decker, Holly B. Kordasiewicz, Katherine E. Savell, Jessica L. Posey, Elizabeth J. Rahn, Brynna S. Paulukaitis, Andrew J. Kennedy, David J. Ecker, Mikael C. Guzman-Karlsson, John W. Lewis, S. Timothy Motley, J. David Sweatt, Jing Wang, Todd P. Michael, Eric E. Swayze, Jeremy J. Day, Sarah K. Strange, Scott E. Phillips
Publikováno v:
Cell Reports, Vol 16, Iss 10, Pp 2666-2685 (2016)
Summary Human haploinsufficiency of the transcription factor Tcf4 leads to a rare autism spectrum disorder called Pitt-Hopkins syndrome (PTHS), which is associated with severe language impairment and development delay. Here, we demonstrate that Tcf4