Epigenomics in Hurthle Cell Neoplasms: Filling in the Gaps Towards Clinical Application

Autor: Sule Canberk, Ana Rita Lima, Mafalda Pinto, Paula Soares, Valdemar Máximo

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

It has been widely described that cancer genomes have frequent alterations to the epigenome, including epigenetic silencing of various tumor suppressor genes with functions in almost all cancer-relevant signalling pathways, such as apoptosis, cell pr

Externí odkaz: https://doaj.org/article/e71991c3027a46cda0a90454beb29f5e

Detection of haplotype-dependent allele-specific DNA methylation in WGBS data

Autor: Y. Fang, Andrew P. Feinberg, John Goutsias, Jordi Abante

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications

In heterozygous genomes, allele-specific measurements can reveal biologically significant differences in DNA methylation between homologous alleles associated with local changes in genetic sequence. Current approaches for detecting such events from w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2e4ebe5cae1290c1b630d318a1f168
http://link.springer.com/article/10.1038/s41467-020-19077-1

Well-differentiated liver cancers reveal the potential link between ACE2 dysfunction and metabolic breakdown

Autor: Desquilles, Lise, Cano, Luis, Ghukasyan, Gevorg, Mouchet, Nicolas, Landreau, Clemence, Corlu, Anne, Clement, Bruno, Turlin, Bruno, Desert, Romain, Musso, Orlando

Publikováno v: Scientific Reports
Scientific Reports, 2022, 12 (1), pp.1859. ⟨10.1038/s41598-021-03710-0⟩
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

International audience; Angiotensin-converting enzyme 2 (ACE2) is the receptor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causing Coronavirus disease 2019 (COVID-19). Transmembrane serine protease 2 (TMPRSS2) is a coreceptor.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::15a29d54228d1082b96f9db5af83b399
http://europepmc.org/articles/PMC8814043

Latency-associated DNA methylation patterns among HIV-1 infected individuals with distinct disease progression courses or antiretroviral virologic response

Autor: Alexandre Defelicibus, N Mantovani, Israel Tojal da Silva, Ricardo Sobhie Diaz, Shirley Vasconcelos Komninakis, James Hunter, Simone de Barros Tenore, Rodrigo Lopes Sanz Duro, Jorge Casseb, Alberto José da Silva Duarte, M Cicero, Milton Yutaka Nishiyama-Jr, Bosco Christiano Maciel da Silva, Daniela Funayama de Castro, Rafael Arnold, Inácio L.M. Junqueira-de-Azevedo, Luiz Claudio Santana

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

DNA methylation is one of the epigenetic modifications that configures gene transcription programs. This study describes the DNA methylation profile of HIV-infected individuals with distinct characteristics related to natural and artificial viremia c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8858d88b5af2013f7eacf996e97bd44a
http://europepmc.org/articles/PMC8626465

Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex

Autor: Faria, Joana, Glover, Lucy, Hutchinson, Sebastian, Boehm, Cordula, Field, Mark C., Horn, David

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.3023. ⟨10.1038/s41467-019-10823-8⟩

The largest gene families in eukaryotes are subject to allelic exclusion, but mechanisms underpinning single allele selection and inheritance remain unclear. Here, we describe a protein complex sustaining variant surface glycoprotein (VSG) allelic ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::413ac617aac13601f6d8db9049163309
http://link.springer.com/article/10.1038/s41467-019-10823-8