Zobrazeno 1 - 10
of 632
pro vyhledávání: '"Epigenetic drugs"'
Autor:
Belén Ocaña-Paredes, Sebastián Rivera-Orellana, David Ramírez-Sánchez, Juliana Montalvo-Guerrero, María Paula Freire, Samantha Espinoza-Ferrao, Adriana Altamirano-Colina, Paulina Echeverría-Espinoza, María José Ramos-Medina, Gabriela Echeverría-Garcés, Danilo Granda-Moncayo, Andrea Jácome-Alvarado, María Gabriela Andrade, Andrés López-Cortés
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Epigenetic modifications, characterized by changes in gene expression without altering the DNA sequence, play a crucial role in the development and progression of cancer by significantly influencing gene activity and cellular function. This insight h
Externí odkaz:
https://doaj.org/article/6aeb0f23da1d4129ad4c7d906668331a
Autor:
Lei Tao, Yue Zhou, Yuan Luo, Jiahao Qiu, Yuzhou Xiao, Jiao Zou, Yu Zhang, Xingchen Liu, Xinyu Yang, Kun Gou, Jing Xu, Xinqi Guan, Xiaobo Cen, Yinglan Zhao
Publikováno v:
MedComm – Oncology, Vol 3, Iss 1, Pp n/a-n/a (2024)
Abstract Epigenetic regulation refers to the alteration of gene expression independent of changes in DNA sequence. It involves chemical modifications such as DNA methylation, histone methylation, and histone acetylation, which are regulated by a coor
Externí odkaz:
https://doaj.org/article/8faf30fe123b49e78b7d9110f48eaa3a
Autor:
Luana Calabrò, Giuseppe Bronte, Federica Grosso, Luigi Cerbone, Angelo Delmonte, Fabio Nicolini, Massimiliano Mazza, Anna Maria Di Giacomo, Alessia Covre, Maria Fortunata Lofiego, Lucio Crinò, Michele Maio
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Pleural mesothelioma (PM) is an aggressive and rare disease, characterized by a very poor prognosis. For almost two decades, the world standard treatment regimen for unresectable PM has consisted of a platinum-based drug plus pemetrexed, leading to a
Externí odkaz:
https://doaj.org/article/8927fd98d7b248cbac772e012b06e713
Publikováno v:
Molecular Biomedicine, Vol 4, Iss 1, Pp 1-32 (2023)
Abstract The tumor microenvironment (TME) is crucial to neoplastic processes, fostering proliferation, angiogenesis and metastasis. Epigenetic regulations, primarily including DNA and RNA methylation, histone modification and non-coding RNA, have bee
Externí odkaz:
https://doaj.org/article/53d2773d09f74da59a4f76e36d603299
Autor:
Marina Baretti, Adrian G. Murphy, Marianna Zahurak, Nicole Gianino, Rose Parkinson, Rosalind Walker, Tamara Y. Lopez-Vidal, Lei Zheng, Gary Rosner, Nita Ahuja, Schalper Kurt, Nilofer S. Azad
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background Approximately 95% of advanced colorectal cancer patients (CRC) have mismatch repair MMR-proficient (MMRp) tumors, which do not respond to PD1 blockade alone. Preclinical studies have shown that combined histone deacetylases (HDAC)
Externí odkaz:
https://doaj.org/article/54d8bce8d548488f940ee627fd83b2ce
Autor:
Agustin Sgro, Joseph Cursons, Charlene Waryah, Eleanor A. Woodward, Momeneh Foroutan, Ruqian Lyu, George C. T. Yeoh, Peter J. Leedman, Pilar Blancafort
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-24 (2023)
Abstract Background Epigenetic silencing of tumor suppressor genes (TSGs) is a key feature of oncogenesis in hepatocellular carcinoma (HCC). Liver-targeted delivery of CRISPR-activation (CRISPRa) systems makes it possible to exploit chromatin plastic
Externí odkaz:
https://doaj.org/article/57f17a1387644e289dd4a0fa2cd044ff
Autor:
Aide Negri, Marina Marozzi, Daniela Trisciuoglio, Dante Rotili, Antonello Mai, Federica Rizzi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Androgen deprivation therapy (ADT) is a common treatment for recurrent prostate cancer (PC). However, after a certain period of responsiveness, ADT resistance occurs virtually in all patients and the disease progresses to lethal metastatic castration
Externí odkaz:
https://doaj.org/article/23a51c8269fc43c7afe46977b921f61a
Autor:
Andrew Zheng, Michelle Bilbao, Janhvi Sookram, Kimberly M. Linden, Andrew B. Morgan, Olga Ostrovsky
Publikováno v:
Cancer Biology & Therapy, Vol 23, Iss 1, Pp 254-264 (2022)
Epigenetic therapy augments neoadjuvant chemotherapy (NACT) in breast cancer and may aid post-surgical wound healing affected by NACT. Our study investigates: (1) The cytotoxicity of classic paclitaxel chemotherapy on triple negative breast cancer (T
Externí odkaz:
https://doaj.org/article/8a72aed558c04ce39edc5747233541be
Autor:
Andrea Anichini, Alessandra Molla, Gabriella Nicolini, Valentina Eleonora Perotti, Francesco Sgambelluri, Alessia Covre, Carolina Fazio, Maria Fortunata Lofiego, Anna Maria Di Giacomo, Sandra Coral, Antonella Manca, Maria Cristina Sini, Marina Pisano, Teresa Noviello, Francesca Caruso, Silvia Brich, Giancarlo Pruneri, Andrea Maurichi, Mario Santinami, Michele Ceccarelli, Giuseppe Palmieri, Michele Maio, Roberta Mortarini, On behalf of the EPigenetic Immune-oncology Consortium AIRC (EPICA) investigators
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-15 (2022)
Abstract Background Improvement of efficacy of immune checkpoint blockade (ICB) remains a major clinical goal. Association of ICB with immunomodulatory epigenetic drugs is an option. However, epigenetic inhibitors show a heterogeneous landscape of ac
Externí odkaz:
https://doaj.org/article/79c74f16caf34f389f373906c070b84d
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
The rampant use of antibiotics in animal husbandry, farming and clinical disease treatment has led to a significant issue with pathogen resistance worldwide over the past decades. The classical mechanisms of resistance typically investigate antimicro
Externí odkaz:
https://doaj.org/article/df318c63fa5d4c4c8e58749fa3da0415