Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Ephrat Levy-Lahad"'
Autor:
Christina Canavati, Dana Sherill-Rofe, Lara Kamal, Idit Bloch, Fouad Zahdeh, Elad Sharon, Batel Terespolsky, Islam Abu Allan, Grace Rabie, Mariana Kawas, Hanin Kassem, Karen B. Avraham, Paul Renbaum, Ephrat Levy-Lahad, Moien Kanaan, Yuval Tabach
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-22 (2024)
Abstract Background Next-generation sequencing (NGS) has significantly transformed the landscape of identifying disease-causing genes associated with genetic disorders. However, a substantial portion of sequenced patients remains undiagnosed. This ma
Externí odkaz:
https://doaj.org/article/7a6f2b28ee0648df98cc0e6225b74bb8
Autor:
Lee Shaashua, Aviad Ben-Shmuel, Meirav Pevsner-Fischer, Gil Friedman, Oshrat Levi-Galibov, Subhiksha Nandakumar, Debra Barki, Reinat Nevo, Lauren E. Brown, Wenhan Zhang, Yaniv Stein, Chen Lior, Han Sang Kim, Linda Bojmar, William R. Jarnagin, Nicolas Lecomte, Shimrit Mayer, Roni Stok, Hend Bishara, Rawand Hamodi, Ephrat Levy-Lahad, Talia Golan, John A. Porco, Christine A. Iacobuzio-Donahue, Nikolaus Schultz, David A. Tuveson, David Lyden, David Kelsen, Ruth Scherz-Shouval
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Cancer-associated fibroblasts are transcriptionally rewired by signals from the cancer cells, resulting in heterogeneous populations. Here the authors show that loss of BRCA function in pancreatic cancer cells leads to HSF1–dependent accumulation o
Externí odkaz:
https://doaj.org/article/ace9d26882394fbe81d1eae2056e5de9
Autor:
Rachel Michaelson-Cohen, Matan J. Cohen, Carmit Cohen, Dan Greenberg, Amir Shmueli, Sari Lieberman, Ariela Tomer, Ephrat Levy-Lahad, Amnon Lahad
Publikováno v:
Cancers, Vol 14, Iss 24, p 6113 (2022)
Identifying carriers of pathogenic BRCA1/BRCA2 variants reduces cancer morbidity and mortality through surveillance and prevention. We analyzed the cost-effectiveness of BRCA1/BRCA2 population screening (PS) in Ashkenazi Jews (AJ), for whom carrier r
Externí odkaz:
https://doaj.org/article/ee574a2c9b1b408388c54bef00935cc5
Autor:
Avraham Steinberg, Ephrat Levy-Lahad, Tami Karni, Noam Zohar, Gil Siegal, Charles L. Sprung, Israel National Bioethics Council, the Ethics Bureau of the Israel Medical Association, and Representatives from the Israeli Ministry of Health
Publikováno v:
Rambam Maimonides Medical Journal, Vol 11, Iss 3, p e0019 (2020)
Objectives This document provides an English translation of the Israeli Joint Commission’s national guidelines for triaging severely ill patients during the coronavirus disease 2019 (COVID-19) pandemic. Methods Four subcommittees of medical, leg
Externí odkaz:
https://doaj.org/article/8b830c711d194194882dc6c8d135153d
Autor:
Danny Zeevi, Joshua S Bloom, Meru J Sadhu, Adi Ben Yehuda, David Zangen, Ephrat Levy-Lahad, Leonid Kruglyak
Publikováno v:
PLoS Genetics, Vol 15, Iss 7, p e1008082 (2019)
Despite intensive study, most of the specific genetic factors that contribute to variation in human height remain undiscovered. We conducted a family-based linkage study of height in a unique cohort of very large nuclear families from a founder (Jewi
Externí odkaz:
https://doaj.org/article/c1a329b34f5449f6ae4eb14a9a42c740
Autor:
Shira Yanovsky-Dagan, Michal Avitzour, Gheona Altarescu, Paul Renbaum, Talia Eldar-Geva, Oshrat Schonberger, Stella Mitrani-Rosenbaum, Ephrat Levy-Lahad, Ramon Y. Birnbaum, Lior Gepstein, Silvina Epsztejn-Litman, Rachel Eiges
Publikováno v:
Stem Cell Reports, Vol 5, Iss 2, Pp 221-231 (2015)
CTG repeat expansion in DMPK, the cause of myotonic dystrophy type 1 (DM1), frequently results in hypermethylation and reduced SIX5 expression. The contribution of hypermethylation to disease pathogenesis and the precise mechanism by which SIX5 expre
Externí odkaz:
https://doaj.org/article/cd5a02d6a12048d9aca4c072ca981984
Autor:
Michal Avitzour, Hagar Mor-Shaked, Shira Yanovsky-Dagan, Shira Aharoni, Gheona Altarescu, Paul Renbaum, Talia Eldar-Geva, Oshrat Schonberger, Ephrat Levy-Lahad, Silvina Epsztejn-Litman, Rachel Eiges
Publikováno v:
Stem Cell Reports, Vol 3, Iss 5, Pp 699-706 (2014)
Fragile X syndrome (FXS) is the most common heritable form of cognitive impairment. It results from epigenetic silencing of the X-linked FMR1 gene by a CGG expansion in its 5′-untranslated region. Taking advantage of a large set of FXS-affected hum
Externí odkaz:
https://doaj.org/article/84318ba0cb7e4d1589dd771a8dc09b08
Publikováno v:
Journal of Clinical Medicine, Vol 3, Iss 2, Pp 432-439 (2014)
The aim of this study was to examine if isolated fetal ventricular septal defect (VSD) is associated with trisomy 21. One hundred twenty six cases with prenatal VSD diagnosed by a pediatric cardiologist were reviewed. Cases with known risk factors fo
Externí odkaz:
https://doaj.org/article/56f3f77d392e44d6bcfa216800a9cfdd
Autor:
Inbal Gazy, David A Zeevi, Paul Renbaum, Sharon Zeligson, Lital Eini, Dana Bashari, Yoav Smith, Amnon Lahad, Michal Goldberg, Doron Ginsberg, Ephrat Levy-Lahad
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134120 (2015)
Expression of RAD51, a crucial player in homologous recombination (HR) and DNA double-strand break (DSB) repair, is dysregulated in human tumors, and can contribute to genomic instability and tumor progression. To further understand RAD51 regulation
Externí odkaz:
https://doaj.org/article/6f1ab59491a44b51971a3152e973f86d
Autor:
Silvina Epsztejn-Litman, Yaara Cohen-Hadad, Shira Aharoni, Gheona Altarescu, Paul Renbaum, Ephrat Levy-Lahad, Oshrat Schonberger, Talia Eldar-Geva, Sharon Zeligson, Rachel Eiges
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0138893 (2015)
We report on the derivation of a diploid 46(XX) human embryonic stem cell (HESC) line that is homozygous for the common deletion associated with Spinal muscular atrophy type 1 (SMA) from a pathenogenetic embryo. By characterizing the methylation stat
Externí odkaz:
https://doaj.org/article/bb761332d1524f5ea4556bdea104c1ed