Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Ephraim L. Tsalik"'
Autor:
Josh G. Chenoweth, Joost Brandsma, Deborah A. Striegel, Pavol Genzor, Elizabeth Chiyka, Paul W. Blair, Subramaniam Krishnan, Elliot Dogbe, Isaac Boakye, Gary B. Fogel, Ephraim L. Tsalik, Christopher W. Woods, Alex Owusu-Ofori, Chris Oppong, George Oduro, Te Vantha, Andrew G. Letizia, Charmagne G. Beckett, Kevin L. Schully, Danielle V. Clark
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-9 (2024)
Abstract Background Sepsis from infection is a global health priority and clinical trials have failed to deliver effective therapeutic interventions. To address complicating heterogeneity in sepsis pathobiology, and improve outcomes, promising precis
Externí odkaz:
https://doaj.org/article/c20dbc2d922941d3a99c931cb0e51535
Autor:
Klaus Schughart, Amber M. Smith, Ephraim L. Tsalik, Stephen C. Threlkeld, Subhashini Sellers, William A. Fischer, Jens Schreiber, Eva Lücke, Markus Cornberg, Jennifer Debarry, Christopher W. Woods, Micah T. McClain, Mark Heise
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionInfluenza virus infections are a major global health problem. Influenza can result in mild/moderate disease or progress to more severe disease, leading to high morbidity and mortality. Severity is thought to be primarily driven by immunop
Externí odkaz:
https://doaj.org/article/da5c678977964239adaadc4fd7821957
Autor:
Emily R. Ko, Megan E. Reller, L. Gayani Tillekeratne, Champica K. Bodinayake, Cameron Miller, Thomas W. Burke, Ricardo Henao, Micah T. McClain, Sunil Suchindran, Bradly Nicholson, Adam Blatt, Elizabeth Petzold, Ephraim L. Tsalik, Ajith Nagahawatte, Vasantha Devasiri, Matthew P. Rubach, Venance P. Maro, Bingileki F. Lwezaula, Wasantha Kodikara-Arachichi, Ruvini Kurukulasooriya, Aruna D. De Silva, Danielle V. Clark, Kevin L. Schully, Deng Madut, J. Stephen Dumler, Cecilia Kato, Renee Galloway, John A. Crump, Geoffrey S. Ginsburg, Timothy D. Minogue, Christopher W. Woods
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Diagnostic limitations challenge management of clinically indistinguishable acute infectious illness globally. Gene expression classification models show great promise distinguishing causes of fever. We generated transcriptional data for a 2
Externí odkaz:
https://doaj.org/article/6b810e23001a49d88802db46e9e5c9d3
Autor:
Micah T. McClain, Ilya Zhbannikov, Lisa L. Satterwhite, Ricardo Henao, Nicholas S. Giroux, Shengli Ding, Thomas W. Burke, Ephraim L. Tsalik, Christina Nix, Jorge Prado Balcazar, Elizabeth A. Petzold, Xiling Shen, Christopher W. Woods
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108288- (2024)
Summary: To elucidate host response elements that define impending decompensation during SARS-CoV-2 infection, we enrolled subjects hospitalized with COVID-19 who were matched for disease severity and comorbidities at the time of admission. We perfor
Externí odkaz:
https://doaj.org/article/6e07d43e0da14020bb61da0c455e7171
Autor:
Jon M. Johannesson, William A. Glover, Cathy A. Petti, Timothy H. Veldman, Ephraim L. Tsalik, Donald H. Taylor, Stephanie Hendren, Coralei E. Neighbors, L. Gayani Tillekeratne, Scott W. Kennedy, Barrie Harper, Warren A. Kibbe, Giselle Corbie, Michael Cohen-Wolkowiez, Christopher W. Woods, Mark J. Lee
Publikováno v:
Frontiers in Public Health, Vol 11 (2023)
IntroductionThe COVID-19 pandemic focused attention on healthcare disparities and inequities faced by individuals within marginalized and structurally disadvantaged groups in the United States. These individuals bore the heaviest burden across this p
Externí odkaz:
https://doaj.org/article/5a828f3a2e9441c1b4378e4869552c09
Autor:
Nicholas S. Giroux, Shengli Ding, Micah T. McClain, Thomas W. Burke, Elizabeth Petzold, Hong A. Chung, Grecia O. Rivera, Ergang Wang, Rui Xi, Shree Bose, Tomer Rotstein, Bradly P. Nicholson, Tianyi Chen, Ricardo Henao, Gregory D. Sempowski, Thomas N. Denny, Maria Iglesias De Ussel, Lisa L. Satterwhite, Emily R. Ko, Geoffrey S. Ginsburg, Bryan D. Kraft, Ephraim L. Tsalik, Xiling Shen, Christopher W. Woods
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/ae1d581ba7ab42f8b29d4929fb064b34
Autor:
Nicholas S. Giroux, Shengli Ding, Micah T. McClain, Thomas W. Burke, Elizabeth Petzold, Hong A. Chung, Grecia O. Rivera, Ergang Wang, Rui Xi, Shree Bose, Tomer Rotstein, Bradly P. Nicholson, Tianyi Chen, Ricardo Henao, Gregory D. Sempowski, Thomas N. Denny, Maria Iglesias De Ussel, Lisa L. Satterwhite, Emily R. Ko, Geoffrey S. Ginsburg, Bryan D. Kraft, Ephraim L. Tsalik, Xiling Shen, Christopher W. Woods
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract SARS-CoV-2 infection triggers profound and variable immune responses in human hosts. Chromatin remodeling has been observed in individuals severely ill or convalescing with COVID-19, but chromatin remodeling early in disease prior to anti-sp
Externí odkaz:
https://doaj.org/article/734bc7f938d44704b53ab81adb346335
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
Optimal management of lower respiratory tract infection relies on distinguishing infectious from noninfectious etiologies and identifying the microbiologic cause if applicable. This process is complicated by overlapping clinical symptoms and the colo
Externí odkaz:
https://doaj.org/article/64cd67f72ade4796a5057ff3ac2bb4d9
Autor:
Zijun Zhang, Natalie Sauerwald, Antonio Cappuccio, Irene Ramos, Venugopalan D. Nair, German Nudelman, Elena Zaslavsky, Yongchao Ge, Angelo Gaitas, Hui Ren, Joel Brockman, Jennifer Geis, Naveen Ramalingam, David King, Micah T. McClain, Christopher W. Woods, Ricardo Henao, Thomas W. Burke, Ephraim L. Tsalik, Carl W. Goforth, Rhonda A. Lizewski, Stephen E. Lizewski, Dawn L. Weir, Andrew G. Letizia, Stuart C. Sealfon, Olga G. Troyanskaya
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 2, Pp 100395- (2023)
Summary: Assays detecting blood transcriptome changes are studied for infectious disease diagnosis. Blood-based RNA alternative splicing (AS) events, which have not been well characterized in pathogen infection, have potential normalization and assay
Externí odkaz:
https://doaj.org/article/5c484ca215b547e3a99a03adad072323
Autor:
Nicholas Bodkin, Melissa Ross, Micah T. McClain, Emily R. Ko, Christopher W. Woods, Geoffrey S. Ginsburg, Ricardo Henao, Ephraim L. Tsalik
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-14 (2022)
Abstract Background Measuring host gene expression is a promising diagnostic strategy to discriminate bacterial and viral infections. Multiple signatures of varying size, complexity, and target populations have been described. However, there is littl
Externí odkaz:
https://doaj.org/article/4bd42597d1644ff6a26c2412f38deb1c