Improved risk-stratification for posterior fossa ependymoma of childhood considering clinical, histological and genetic features – a retrospective analysis of the HIT ependymoma trial cohort

Autor: André O. von Bueren, Martin Mynarek, Stefan Rutkowski, Ludger Klein-Hitpass, Inken Wohlers, Torsten Pietsch, Stephanie T Jünger, Sven Rahmann, Beate Timmermann, Natalia Velez-Char, Monika Warmuth-Metz, Katja von Hoff, Rolf-Dieter Kortmann, Evelyn Dörner, Anja zur Mühlen

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-12 (2019)
Acta Neuropathologica Communications
Acta neuropathologica communications, Vol. 7, No 1 (2019) P. 181

Introduction Risk stratification of children with ependymomas of the posterior fossa in current therapeutic protocols is mainly based on clinical criteria. We aimed to identify independent outcome predictors for this disease entity by a systematic in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af76a756fc70196b913cc6a2c917e0a
http://link.springer.com/article/10.1186/s40478-019-0820-5

Integrating Tenascin-C protein expression and 1q25 copy number status in pediatric intracranial ependymoma prognostication: A new model for risk stratification

Autor: John-Paul Kilday, Hendrik Witt, Stefan M. Pfister, Mohamed Amine Bayar, Richard Grundy, Felipe Andreiuolo, Maura Massimino, Stefan Rutkowski, Andrey Korshunov, Jacques Grill, Pascale Varlet, Gwénaël Le Teuff, Leila Chimelli, Adolescents, Mélanie Pagès, Didier Frappaz, David Castel, Piergiorgio Modena, André O. von Bueren, Torsten Pietsch, Felice Giangaspero

Publikováno v: PloS one, Vol. 12, No 6 (2017) P. e0178351
PLoS ONE, Vol 12, Iss 6, p e0178351 (2017)
Andreiuolo, F, Le Teuff, G, Bayar, M A, Kilday, J P, Pietsch, T, von Bueren, A O, Witt, H, Korshunov, A, Modena, P, Pfister, S M, Pagès, M, Castel, D, Giangaspero, F, Chimelli, L, Varlet, P, Rutkowski, S, Frappaz, D, Massimino, M, Grundy, R & Grill, J 2017, ' Integrating Tenascin-C protein expression and 1q25 copy number status in pediatric intracranial ependymoma prognostication : A new model for risk stratification ', PLoS ONE, vol. 12, no. 6, e0178351 . https://doi.org/10.1371/journal.pone.0178351
PLoS ONE

Purpose: Despite multimodal therapy, prognosis of pediatric intracranial ependymomas remains poor with a 5-year survival rate below 70% and frequent late deaths. Experimental design: This multicentric European study evaluated putative prognostic biom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c232d8dbe7251dca2ef0c28ad1b5c30
https://archive-ouverte.unige.ch/unige:157187

Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma

Autor: Marie-Magdeleine Ruchoux, Jacqueline Mikol, Isabelle Salmon, Dominique Figarella-Branger, David W. Ellison, Emmanuel Rousseau, Francesco Scaravilli, Catherine Lacroix, Thomas Palm, Catherine Godfraind, Miikka Vikkula, Françoise Chapon

Publikováno v: Molecular Cancer, Vol 6, Iss 1, p 47 (2007)
Molecular Cancer, Vol. 6, p. 47 [1-10] (2007)
Molecular Cancer
Molecular cancer, 6

Ependymal tumors constitute a clinicopathologically heterogeneous group of brain tumors. They vary in regard to their age at first symptom, localization, morphology and prognosis. Genetic data also suggests heterogeneity. We define a newly recognized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af54cbe2d2dac6f2f69f1a8c767f0ba
http://www.molecular-cancer.com/content/6/1/47

Genetic abnormalities in oligodendroglial and ependymal tumours

Autor: Goussia, A. C., Kyritsis, A. P., Mitlianga, P., Bruner, J. M.

Oligodendroglial and ependymal tumours are not the most common glial neoplasms; however, they are important subtypes of gliomas with different tumour biologies. Cytogenetic information has suggested that losses of chromosomes 1 p and 19 q are the mos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::85e57482e36ad2e2b1df07ad3011c78b
http://olympias.lib.uoi.gr/jspui/handle/123456789/21434