Zobrazeno 1 - 10
of 49
pro vyhledávání: '"EpCam, Epithelial cell adhesion molecule"'
Publikováno v:
Journal of Genetic Engineering and Biotechnology, Vol 19, Iss 1, Pp 1-8 (2021)
Abstract Background Overexpression of the EpCAM (epithelial cell adhesion molecule) in malignancies makes it an attractive target for passive immunotherapy in a wide range of carcinomas. In comparison with full-length antibodies, due to the small siz
Externí odkaz:
https://doaj.org/article/182f24e22e1d466fac9ec53fd4dcd71e
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1353-1371 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Congenital tufting enteropathy (CTE) is an intractable diarrheal disease of infancy caused by mutations of epithelial cell adhesion molecule (EpCAM). The cellular and molecular basis of CTE pathology has been elusive. We hypothesize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd57cdfe5b62c31ab3e478c97bd8551
http://www.sciencedirect.com/science/article/pii/S2352345X21001302
http://www.sciencedirect.com/science/article/pii/S2352345X21001302
Autor:
Zhouhong Ge, Ron Smits, Lucia Campos Carrascosa, Dave Sprengers, Jaap Kwekkeboom, Jan N. M. IJzermans, Guoying Zhou, Maikel P. Peppelenbosch, Ruby Lieshout, Ling Wang, Wanlu Cao, Lisanne Noordam, Pengfei Li, Qin Yang, Junhong Su, Jiaye Liu, Luc J. W. van der Laan, Meng Li, Buyun Ma, Monique M A Verstegen, Qiuwei Pan, Ruyi Zhang
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, 11(2), 407-431. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology, 11(2), 407-431. Elsevier Inc.
Background & Aims Cancer-associated fibroblasts (CAFs) play a key role in the cancer process, but the research progress is hampered by the paucity of preclinical models that are essential for mechanistic dissection of cancer cell–CAF interactions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf0768c949717d28cf96aa15fc39b91
https://doi.org/10.1016/j.jcmgh.2020.09.003
https://doi.org/10.1016/j.jcmgh.2020.09.003
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 55-70 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Cancer stem cells (CSCs) are a subpopulation of cancer cells with functions similar to those of normal stem cells. Although few in number, they are capable of self-renewal, unlimited proliferation, and multi-directional differentiation potential. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa624bee1b295d3b2a8ea11ea5504c8
http://www.sciencedirect.com/science/article/pii/S2211383520307322
http://www.sciencedirect.com/science/article/pii/S2211383520307322
Autor:
Wolfgang Walther, Annika Wulf-Goldenberg, Ulrike Stein, Johannes Merk, Iduna Fichtner, Keziban M. Alp, Giannino Patone, Tamara Kanashova, Christine Sers, Philipp Mertins, Maria Rivera, Jens Hoffmann
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 21-35 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 21-35 (2021)
Patient-derived xenograft (PDX) tumor models represent a valuable platform for identifying new biomarkers and novel targets, to evaluate therapy response and resistance mechanisms. This study aimed at establishment, characterization and therapy testi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8082ec6c5f41c16d128a521a50759417
https://doi.org/10.1016/j.neo.2020.11.005
https://doi.org/10.1016/j.neo.2020.11.005
Autor:
Jan Koster, Pim J. Koelink, Manon van Roest, Sander Meisner, Ingrid B. Renes, William J. Faller, Joana Silva, Wouter L. Smit, Jacqueline L.M. Vermeulen, Manon E. Wildenberg, Vanesa Muncan, Ruurd M. van Elburg, Tânia Martins Garcia
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 943-981 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, 12(3), 943-981. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, 12(3), 943-981. Elsevier Inc.
Background & Aims The use of antibiotics (ABs) is a common practice during the first months of life. ABs can perturb the intestinal microbiota, indirectly influencing the intestinal epithelial cells (IECs), but can also directly affect IECs independe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c861cf76325ee471195673d49383545
http://www.sciencedirect.com/science/article/pii/S2352345X21001132
http://www.sciencedirect.com/science/article/pii/S2352345X21001132
Autor:
Christine P. Petersen, Kevin A. Bockerstett, Richard J. DiPaolo, Christine N. Noto, Ryan M. Teague, Lindsey M. Kuehm, Eric L. Ford, Jason C. Mills, James R. Goldenring, Chun Fung Wong
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 561-579 (2020)
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 561-579 (2020)
Background & Aims The association between chronic inflammation and gastric carcinogenesis is well established, but it is not clear how immune cells and cytokines regulate this process. We investigated the role of interleukin 27 (IL27) in the developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5944bc3c0b7785e1a2d843431f7bb28f
http://europepmc.org/articles/PMC7399182
http://europepmc.org/articles/PMC7399182
Autor:
Hyemin Kim, Chan Mi Heo, Jinmyeong Oh, Hwe Hoon Chung, Eun Mi Lee, Juhee Park, Se-Hoon Lee, Kwang Hyuck Lee, Kyu Taek Lee, Jong Kyun Lee, Yoon-Kyoung Cho, Joo Kyung Park
Publikováno v:
Translational Oncology, Vol 16, Iss, Pp 101321-(2022)
Translational Oncology
Translational Oncology
Highlights • CTCs can be reliably captured with a microfluidic disc in unresectable PDAC patients. • EpCAM/CK and additional Plectin-1 can effectively identify PDAC CTCs. • Decreased number of CTCs after chemotherapy is associated with longer s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02ec91e048685e10e6224d565a91512
http://www.sciencedirect.com/science/article/pii/S1936523321003120
http://www.sciencedirect.com/science/article/pii/S1936523321003120
Publikováno v:
Translational Oncology, Vol 14, Iss 11, Pp 101207-(2021)
Translational Oncology
Translational Oncology
Highlights • D5D is an independent prognostic factor in cancer. • D5D aggravates cancer progression via mediating AA/PGE2 production from DGLA. • AA/PGE2 promotes cancer progression via regulating the tumor microenvironment. • Inhibition of D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81cba5e09eeffe1477f02b7b3cd5fa8
http://www.sciencedirect.com/science/article/pii/S1936523321001996
http://www.sciencedirect.com/science/article/pii/S1936523321001996
Autor:
Yugang Wang, James Henderson, Udit Singhal, Ganesh S. Palapattu, Alexander Zaslavsky, Zachery R. Reichert, Jae Seung Chung, Daniel E. Spratt, Yuanyuan Qiao, Russell S. Taichman, Daniel H. Hovelson, Todd M. Morgan, Scott A. Tomlins
Publikováno v:
Neoplasia (New York, N.Y.)
While circulating tumor cell (CTC)–based detection of AR-V7 has been demonstrated to predict patient response to second-generation androgen receptor therapies, the rarity of AR-V7 expression in metastatic castrate-resistant prostate cancer (mCRPC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccca5865d7eba17853cb45660e1726c2
http://europepmc.org/articles/PMC6612010
http://europepmc.org/articles/PMC6612010