Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Eoin R Gould"'
Autor:
Lindsay B Tulloch, Stefanie K Menzies, Andrew L Fraser, Eoin R Gould, Elizabeth F King, Marija K Zacharova, Gordon J Florence, Terry K Smith
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 9, p e0005886 (2017)
Current drugs to treat African sleeping sickness are inadequate and new therapies are urgently required. As part of a medicinal chemistry programme based upon the simplification of acetogenin-type ether scaffolds, we previously reported the promising
Externí odkaz:
https://doaj.org/article/d7cf23932e2a4bed826d40db10641a11
Autor:
Terry K. Smith, Marija K. Zacharova, Gordon J. Florence, Stefanie K. Menzies, Lindsay B. Tulloch, Marie I. Thomson, Andrew L. Fraser, Elizabeth F. B. King, Joanne C. Morris, Eoin R. Gould
Publikováno v:
Chemmedchem
Neglected tropical diseases caused by parasitic infections are an ongoing and increasing concern. They are a burden to human and animal health, having the most devastating effect on the world′s poorest countries. Building upon our previously report
Autor:
Magnus S. Alphey, Gemma Fisher, Ying Ge, Eoin R. Gould, Teresa F. G. Machado, Huanting Liu, Gordon J. Florence, James H. Naismith, Rafael G. da Silva
Publikováno v:
ACS Catalysis. 8(6)
This work was supported by the University of St Andrews, a Leverhulme Trust grant (RL - 2012 - 025) to G.J.F, the Engineering and Physical Sciences Research Council (EPSRC) [grant number EP/L016419/1] via a CRITICAT Centre for Doctoral Training stude
Autor:
Marija K. Zacharova, Gordon J. Florence, Andrew L. Fraser, Elizabeth F. B. King, Eoin R. Gould, Lindsay B. Tulloch, Stefanie K. Menzies, Terry K. Smith
This work was funded by the Leverhulme Trust (GJF) and the European Community’s Seventh Framework Programme under grant agreement No. 602773 [Project KINDRED] (TKS). Neglected tropical diseases caused by parasitic infections are an ongoing and incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6293b473edfeb86152a0498eab6a9686
https://hdl.handle.net/10023/16803
https://hdl.handle.net/10023/16803
Autor:
Pei Pei Yeh, David S. B. Daniels, Carmen Simal, James E. Taylor, Charlene Fallan, Andrew D. Smith, Eoin R. Gould, Alexandra M. Z. Slawin
Publikováno v:
Organic & Biomolecular Chemistry. 13:2177-2191
The authors thank the Royal Society for a University Research Fellowship (ADS), the EU (IEF for CS) and the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) ERC Grant Agreement No. 279850 (JET and CF)
Autor:
Lindsay B. Tulloch, Gordon J. Florence, Marija K. Zacharova, Terry K. Smith, Andrew L. Fraser, Stefanie K. Menzies, Eoin R. Gould, Elizabeth F. B. King
Publikováno v:
Bioorganicmedicinal chemistry. 25(22)
This work was funded by the Leverhulme Trust. The research data supporting this publication can be accessed at http://dx.doi.org/10.17630/1dd8b881-17c2-48e4-a72f-53af938f4537. The need for new treatments for the neglected tropical diseases African sl
Publikováno v:
Tetrahedron. 66:8992-9008
A range of pyrazolidin-3-ones have been prepared and their activity as catalysts for iminium-ion promoted Diels–Alder reactions evaluated. Systematic variation of the C(5)- and N(2)-substituents indicates that the incorporation of an electron withd
Autor:
Lindsay Tulloch, Stefanie K. Menzies, Andrew L. Fraser, Eoin R. Gould, Joanne C. Morris, Elizabeth F. King, Marija K. Zacharova, Terry K. Smith, Gordon J. Florence
The acetogenin family of polyketides produced by annonaceacous plants has broad anti-microbial activity through its potent inhibition of mitochondrial complex I. We recently reported [Florence, Chem. Med. Chem. 9;2548 (2014)] the trypanocidal activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d20461751f281adbe0ddc804d06d78ac
ChemInform Abstract: Exploring the Scope of the Isothiourea-Mediated Synthesis of Dihydropyridinones
Autor:
David S. B. Daniels, Eoin R. Gould, Carmen Simal, Pei Pei Yeh, Charlene Fallan, Alexandra M. Z. Slawin, Andrew D. Smith, James E. Taylor
Publikováno v:
ChemInform. 46
Tetramisole-mediated reaction of 2-substituted acetic acids (I) and (IV) and α,β-unsaturated ketimines (II) gives the title compounds in good to high yields and with excellent stereoselectivities.
Autor:
Gordon J. Florence, Andrew L. Fraser, Stefanie K. Menzies, Eoin R. Gould, Joanne C. Morris, Lindsay B. Tulloch, Elizabeth F. B. King, Terry K. Smith
Publikováno v:
ChemMedChem. 9(11)
Neglected tropical diseases remain a serious global health concern. Here, a series of novel bis-tetrahydropyran 1,4-triazole analogues based on the framework of chamuvarinin, a polyketide natural product isolated from the annonaceae plant species are