Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Eoin P, Cummins"'
Autor:
David E. Phelan, Ben Reddan, Masahiko Shigemura, Jacob I. Sznajder, Daniel Crean, Eoin P. Cummins
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2852 (2024)
Hypercapnia occurs when the partial pressure of carbon dioxide (CO2) in the blood exceeds 45 mmHg. Hypercapnia is associated with several lung pathologies and is transcriptionally linked to suppression of immune and inflammatory signalling through po
Externí odkaz:
https://doaj.org/article/a538e415c47d4983ab84f11c5a7733b9
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/9c28f73c0aab4e9ca7bd688e4d8d7c16
Autor:
David E. Phelan, Masahiko Shigemura, Sarah Aldhafiri, Catarina Mota, Thomas J. Hall, Jacob I. Sznajder, Evelyn P. Murphy, Daniel Crean, Eoin P. Cummins
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The nuclear receptor sub-family 4 group A (NR4A) family are early response genes that encode proteins that are activated in several tissues/cells in response to a variety of stressors. The NR4A family comprises NR4A1, NR4A2 and NR4A3 of which NR4A2 a
Externí odkaz:
https://doaj.org/article/5f6313cef0a746c58a9dc45ec6c10ed8
Autor:
Moritz J. Strowitzki, Marc Bleul, Christopher Tuffs, Mareen Dupovac, Alfonso Blanco, Eoin P. Cummins, Martin Schneider, Cormac Taylor
Publikováno v:
Physiology. 38
Background: Increased levels of CO2 reduce macrophage function during inflammatory processes and wound healing. However, little is known how macrophages sense CO2 and adapt upon high levels of CO2 during differentiation and activation. We, therefore,
Autor:
David E Phelan, Catarina Mota, Moritz J Strowitzki, Masahiko Shigemura, Jacob I Sznajder, Louise Crowe, Joanne C Masterson, Sophie E Hayes, Ben Reddan, Xiaofei Yin, Lorraine Brennan, Daniel Crean, Eoin P Cummins
Publikováno v:
Immunology & Cell Biology.
Autor:
Matt McGovern, Eleanor J. Molloy, M Chim, Niamh Lagan, A Butler, John Allen, J Tyrrell, J Meehan, Tim Hurley, Eoin P. Cummins, Sie Kei Wong, M Omer
Publikováno v:
Pediatric Research. 91:1049-1056
Abstract There is no consensus on the optimal pCO2 levels in the newborn. We reviewed the effects of hypercapnia and hypocapnia and existing carbon dioxide thresholds in neonates. A systematic review was conducted in accordance with the PRISMA statem
Publikováno v:
Cells, Vol 8, Iss 5, p 384 (2019)
All metazoans that utilize molecular oxygen (O2) for metabolic purposes have the capacity to adapt to hypoxia, the condition that arises when O2 demand exceeds supply. This is mediated through activation of the hypoxia-inducible factor (HIF) pathway.
Externí odkaz:
https://doaj.org/article/6f279bdbc63143f4986b347c3a48a102
Autor:
Carsten C Scholz, Javier Rodriguez, Christina Pickel, Stephen Burr, Jacqueline-Alba Fabrizio, Karen A Nolan, Patrick Spielmann, Miguel A S Cavadas, Bianca Crifo, Doug N Halligan, James A Nathan, Daniel J Peet, Roland H Wenger, Alex Von Kriegsheim, Eoin P Cummins, Cormac T Taylor
Publikováno v:
PLoS Biology, Vol 14, Iss 1, p e1002347 (2016)
The asparagine hydroxylase, factor inhibiting HIF (FIH), confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to hypoxia. Studies investigating whether asparagine hydroxylation is a g
Externí odkaz:
https://doaj.org/article/195eb6b4e4534a8d981fea77cbdb36dd
Autor:
Cormac T. Taylor, G. R. Scott Budinger, Ankit Bharat, Iiro Taneli Helenius, Yosef Gruenbaum, Laura A. Dada, Melanie B. Edwards, Sergejs Berdnikovs, Cara J. Gottardi, Peter H. S. Sporn, István Vadász, Kfir Sharabi, Martín Angulo, Gustavo A. Nader, Emilia Lecuona, Naftali Kaminski, Jacob I. Sznajder, Eoin P. Cummins, Masahiko Shigemura, Lynn C. Welch, Greg J. Beitel, S. Marina Casalino-Matsuda
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports
Scientific Reports
Carbon dioxide (CO2) is sensed by cells and can trigger signals to modify gene expression in different tissues leading to changes in organismal functions. Despite accumulating evidence that several pathways in various organisms are responsive to CO2
Autor:
Moritz J. Strowitzki, Ross Nelson, Mario P. Garcia, Christopher Tuffs, Marc B. Bleul, Stephen Fitzsimons, Javier Navas, Ilona Uzieliene, Alina S. Ritter, David Phelan, Sarah J. Kierans, Alfonso Blanco, Eiva Bernotiene, Orina Belton, Martin Schneider, Eoin P. Cummins, Cormac T. Taylor
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 208(10)
CO2, the primary gaseous product of respiration, is a major physiologic gas, the biology of which is poorly understood. Elevated CO2 is a feature of the microenvironment in multiple inflammatory diseases that suppresses immune cell activity. However,