Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Eoin F McKinney"'
Publikováno v:
PLOS Digital Health, Vol 2, Iss 6, p e0000276 (2023)
Diagnostic and prognostic models are increasingly important in medicine and inform many clinical decisions. Recently, machine learning approaches have shown improvement over conventional modeling techniques by better capturing complex interactions be
Externí odkaz:
https://doaj.org/article/bf29cdfab67c40f297bbffc642f42f22
Autor:
Mark Toshner, Benjamin J Dunmore, Eoin F McKinney, Mark Southwood, Paola Caruso, Paul D Upton, John P Waters, Mark L Ormiston, Jeremy N Skepper, Gerard Nash, Amer A Rana, Nicholas W Morrell
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91334 (2014)
The endothelial cell has a remarkable ability for sub-specialisation, adapted to the needs of a variety of vascular beds. The role of developmental programming versus the tissue contextual environment for this specialization is not well understood. H
Externí odkaz:
https://doaj.org/article/a65b5f6b922b480a9cbe22102ede147c
Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.
Autor:
Vojislav Jovanović, Nurhuda Abdul Aziz, Yan Ting Lim, Amanda Ng Ai Poh, Sherlynn Jin Hui Chan, Eliza Ho Xin Pei, Fei Chuin Lew, Guanghou Shui, Andrew M Jenner, Li Bowen, Eoin F McKinney, Paul A Lyons, Michael D Kemeny, Kenneth G C Smith, Markus R Wenk, Paul A Macary
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55639 (2013)
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by broad clinical manifestations including cardiovascular and renal complications with periodic disease flares and significant morbidity and mortality. One of the main
Externí odkaz:
https://doaj.org/article/e9d92f41f9d141d2bcea8a5d77b6f715
Autor:
Vanessa Buchanan, Susan Griffin, Warda Tahir, Karen Hills, Miles Parkes, Kenneth GC Smith, Paul A Lyons, James C Lee, Eoin F McKinney
ObjectiveTo evaluate the cost-effectiveness of a personalised medicine strategy for Crohn’s disease in the UK, using early targeted top-down therapy compared to standard of care.Materials & MethodsA decision tree leading into a Markov state-transit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38ae021967e5f7d53f3b5d9b69fbc8ef
https://doi.org/10.1101/2022.12.01.22281309
https://doi.org/10.1101/2022.12.01.22281309
Autor:
Margarete A. Fabre, José Guilherme de Almeida, Edoardo Fiorillo, Emily Mitchell, Aristi Damaskou, Justyna Rak, Valeria Orrù, Michele Marongiu, Michael Spencer Chapman, M. S. Vijayabaskar, Joanna Baxter, Claire Hardy, Federico Abascal, Nicholas Williams, Jyoti Nangalia, Iñigo Martincorena, Peter J. Campbell, Eoin F. McKinney, Francesco Cucca, Moritz Gerstung, George S. Vassiliou
Funder: European Research Council
Clonal expansions driven by somatic mutations become pervasive across human tissues with age, including in the haematopoietic system, where the phenomenon is termed clonal haematopoiesis1-4. The understanding of
Clonal expansions driven by somatic mutations become pervasive across human tissues with age, including in the haematopoietic system, where the phenomenon is termed clonal haematopoiesis1-4. The understanding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193bfe0782a4fe26b54f51401d33bd24
https://www.repository.cam.ac.uk/handle/1810/337905
https://www.repository.cam.ac.uk/handle/1810/337905
Autor:
Robert Mackenzie Ross, Natalia Savinykh, Stephen David Coleman, Emily Groves, Gary Polwarth, John Gerry Coghlan, Christopher J. Rhodes, Martin R. Wilkins, Jennifer M. Martin, James Lordan, Francesco Cucca, Eckart De Bie, Chris Wallace, Kasia I. Zalewska, Martin Johnson, Carmen M. Treacy, Allan Lawrie, Paul A. Corris, Colin Church, David G. Kiely, Jingxu Guo, Stefan Gräf, Helen Baxendale, Luke Howard, Mark Toshner, Emilia M. Swietlik, Edoardo Fiorillo, Valeria Orrù, Eoin F. McKinney, S.John Wort, Rowena Jones, Nicholas W. Morrell, Joanna Pepke Zaba
Background: Autoimmunity may play a role in idiopathic pulmonary arterial hypertension (IPAH). It is not clear if this is causative, or as a bystander of disease and if it carries any prognostic or treatment significance. Methods: Comprehensive immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6baf6b75a438a452f085e0d05b1dc08
SummaryType 1 diabetes (T1D) is an autoimmune disease characterised by T cell-mediated destruction of the insulin-producing β cells in the pancreas. Similar to other autoimmune diseases, the incidence of T1D is increasing globally. The discovery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0c483f2e5facf4e40fc6d7380732de
Autor:
Prasanti Kotagiri, Mark R. Wills, Kelvin Hunter, William Rae, Laura Bergamaschi, Ravindra K. Gupta, John Bradley, Nicholas J Matheson, Eoin F. McKinney, Myra Hosmillo, Paul A. Lyons, Menna R. Clatworthy, Zewen Tuong, Lorinda Turner, Ian Goodfellow, Rachael Bashford-Rogers, Federica Mescia, Kenneth G. C. Smith, Federico Pehuen Pereyra Gerber, Christoph Hess
Publikováno v:
Cell Reports
B cells are important in immunity to both SARS-CoV-2 infection and vaccination, but B cell receptor (BCR) repertoire development in these contexts has not been compared. We analyse serial samples from 171 SARS-CoV-2-infected individuals and 63 vaccin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3ea5d45d6367ed99accf14f833d316
http://hdl.handle.net/11379/562780
http://hdl.handle.net/11379/562780
Autor:
Maria J. Redondo, Kevan C. Herold, Mark A. Atkinson, Simi Ahmed, David A. G. Skibinski, Polly J. Bingley, Peter A. Gottlieb, Mark Peakman, S. Alice Long, Linda A. DiMeglio, Alessandra Petrelli, Richard A. Oram, Carla J. Greenbaum, Markus Lundgren, Mark S. Anderson, Desmond A. Schatz, Noel G. Morgan, Carmella Evans-Molina, Manuela Battaglia, Xiaoning Qian, Tomi Pastinen, Dorothy J. Becker, Eoin F. McKinney, Todd M. Brusko, Emanuele Bosi, Bart O. Roep, Jeffrey P. Krischer, Martin J. Hessner, Stephen E. Gitelman, Mikael Knip, Laura M. Jacobsen, Michael C. Peters
Publikováno v:
Diabetes Care
The clinical diagnosis of new-onset type 1 diabetes has, for many years, been considered relatively straightforward. Recently, however, there is increasing awareness that within this single clinical phenotype exists considerable heterogeneity: diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28537cfa6851fd3118b18969e39f2fad
Autor:
Edoardo Fiorillo, Peter J. Campbell, J. G. de Almeida, Jyoti Nangalia, Valeria Orrù, Eoin F. McKinney, Claire Hardy, Michele Marongiu, M S Vijayabaskar, Justyna Rak, Michael Spencer Chapman, Nitin Williams, Francesco Cucca, Aristi Damaskou, George S. Vassiliou, Inigo Martincorena, M. A. Fabre, Federico Abascal, Moritz Gerstung, Emily G. Mitchell, Joanna Baxter
SummaryHuman cells acquire somatic mutations throughout life, some of which can drive clonal expansion. Such expansions are frequent in the haematopoietic system of healthy individuals and have been termed clonal haematopoiesis (CH). While CH predisp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb0806b201294fb0de2288e800e5618a
https://doi.org/10.1101/2021.08.12.455048
https://doi.org/10.1101/2021.08.12.455048