Výsledky vyhledávání - "Eoin C. O'Leary"

Glucocorticoid-mediated inhibition of neutrophil emigration in an endotoxin-induced rat pulmonary inflammation model occurs without an effect on airways MIP-2 levels

Autor: Eoin C. O'Leary, S H Zuckerman

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 16:267-274

In an intratracheal endotoxin lipopolysaccharide (LPS) challenge model of acute lung injury, we recently reported that while dexamethasone (DEX) at 2 to 4 mg/kg reduced neutrophil (PMN) emigration into the airways, bronchoalveolar lavage (BAL) fluid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0877e24a2c3e420da889e3a10949a1
https://doi.org/10.1165/ajrcmb.16.3.9070611

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Autor: Glenn F. Evans, Eoin C. O'Leary, Steven H. Zuckerman

Publikováno v: Inflammation. 21:597-608

Glucocorticoids, while potent antiinflammatory agents, have not been proven to be efficacious in Acute Respiratory Distress Syndrome, ARDS. Previous studies from this laboratory have reported that dexamethasone pretreatment of rats resulted in a 40�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36b26f962f73eca79954b55ed86318ef
https://doi.org/10.1023/a:1027382005549

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SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

Autor: Aparna Motiwala, Steve Pierce, Yoshitaka Satoh, Jim C. Leisten, Dennis T. Sasaki, Shripad S. Bhagwat, Eoin C. O'leary, Steve T. Sakata, Brydon L. Bennett, Brion W. Murray, David W. Anderson, Anthony M. Manning, Weiming Xu

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 98(24)

Jun N-terminal kinase (JNK) is a stress-activated protein kinase that can be induced by inflammatory cytokines, bacterial endotoxin, osmotic shock, UV radiation, and hypoxia. We report the identification of an anthrapyrazolone series with significant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7427a0993da5f7bf44fa1ef2b23055b
https://pubmed.ncbi.nlm.nih.gov/11717429

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Glucocorticoid effects in an endotoxin-induced rat pulmonary inflammation model: differential effects on neutrophil influx, integrin expression, and inflammatory mediators

Autor: Philip Marder, Eoin C. O'Leary, Steven H. Zuckerman

Publikováno v: American journal of respiratory cell and molecular biology. 15(1)

To understand the basis for the refractory nature of acute respiratory distress syndrome (ARDS) to glucocorticoids, the effects of dexamethasone pretreatment (DEX, 2 mg/kg, intraperitoneally) on the kinetics of airway tumor necrosis factor-alpha (TNF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d379cac188017021c3d09d2a52ec0a95
https://pubmed.ncbi.nlm.nih.gov/8679228

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