Approches multi-échelles pour aider à clarifier les mécanismes impliqués dans les processus d'activation/inhibition de systèmes biologiques importants

Autor: Parise, Angela

Investigating biomolecular processes is challenging because of the intrinsic multi-scale hierarchical organization in system size and time in which chemical and chemical physical phenomena occur. Theoretical methods applied to biomolecules deals with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______166::716f350f8afb5e4b3f4f5252cc66cab9
https://theses.hal.science/tel-03714141

Etude structurale et fonctionnelle de la protéine à radical SAM Hyde

Autor: Rohac, Roman

Les protéines à radical S-adénosyl-L-méthionine (SAM) utilisent un centre [Fe4S4] réduit pour initier le clivage réductive homolytique de la SAM et la formation d'une espèce hautement réactive - le radical 5'-déoxyadénosyl ou 5'-dA•. Dans

Externí odkaz: http://www.theses.fr/2016GREAV010/document

L-tyrosine-bound ThiH structure reveals C-C bond break differences within radical SAM aromatic amino acid lyases

Autor: Patricia Amara, Claire Saragaglia, Jean-Marie Mouesca, Lydie Martin, Yvain Nicolet

Publikováno v: Nature Communications
Nature Communications, 2022, 13 (1), pp.2284. ⟨10.1038/s41467-022-29980-4⟩

2-iminoacetate synthase ThiH is a radical S-adenosyl-L-methionine (SAM) L-tyrosine lyase and catalyzes the L-tyrosine Cα–Cβ bond break to produce dehydroglycine and p-cresol while the radical SAM L-tryptophan lyase NosL cleaves the L-tryptophan C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300785c8e8b59f75ab19d81a0e23c253
https://pubmed.ncbi.nlm.nih.gov/35477710

Radical S -Adenosyl- l -methionine Tryptophan Lyase (NosL): How the Protein Controls the Carboxyl Radical •CO 2 – Migration

Autor: Maxime Bella, Yvain Nicolet, Lydie Martin, Jean-Marie Mouesca, Patricia Amara, Claire Saragaglia, Serge Gambarelli

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2018, 140 (48), pp.16661-16668. ⟨10.1021/jacs.8b09142⟩
Journal of the American Chemical Society, 2018, 140 (48), pp.16661-16668. ⟨10.1021/jacs.8b09142⟩

International audience; The radical S-adenosyl-l-methionine tryptophan lyase uses radical-based chemistry to convert l-tryptophan into 3-methyl-2-indolic acid, a fragment in the biosynthesis of the thiopeptide antibiotic nosiheptide. This complex rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8372c1ceeeedecfd0768a8be9788bca5
https://hal.archives-ouvertes.fr/hal-02008403

Characterization, Properties and Applications

Autor: Tracey Rouault

This volume on iron-sulfur proteins includes chapters that describe the initial discovery of iron-sulfur proteins in the 1960s to elucidation of the roles of iron sulfur clusters as prosthetic groups of enzymes, such as the citric acid cycle enzyme,