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Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family

Autor: Youngchang Kim, Seung Hwan Lee, Priyanka Gade, Maren Nattermann, Natalia Maltseva, Michael Endres, Jing Chen, Philipp Wichmann, Yang Hu, Daniel G. Marchal, Yasuo Yoshikuni, Tobias J. Erb, Ramon Gonzalez, Karolina Michalska, Andrzej Joachimiak

Publikováno v: Communications Chemistry, Vol 7, Iss 1, Pp 1-10 (2024)

Abstract 2-Hydroxyacyl-CoA lyase/synthase (HACL/S) is a thiamine diphosphate (ThDP)-dependent versatile enzyme originally discovered in the mammalian α-oxidation pathway. HACL/S natively cleaves 2-hydroxyacyl-CoAs and, in its reverse direction, cond

Externí odkaz: https://doaj.org/article/6aa21acb3e0a48658c899fdf3ca1d48f

PredictEFC: a fast and efficient multi-label classifier for predicting enzyme family classes

Autor: Lei Chen, Chenyu Zhang, Jing Xu

Publikováno v: BMC Bioinformatics, Vol 25, Iss 1, Pp 1-27 (2024)

Abstract Background Enzymes play an irreplaceable and important role in maintaining the lives of living organisms. The Enzyme Commission (EC) number of an enzyme indicates its essential functions. Correct identification of the first digit (family cla

Externí odkaz: https://doaj.org/article/463781f25c6c49fca717d1e33dfc2821

The difference is black and green: How functional divergence of an enzyme family gave us diverse teas.

Autor: Howe V; Assistant Features Editor, The Plant Cell, American Society of Plant Biologists.; Department of Developmental Genetics, Heinrich-Heine University, Düsseldorf, Germany, 40225.

Publikováno v: The Plant cell [Plant Cell] 2024 Dec 23; Vol. 37 (1).